Comparison of Planned Versus Actual Dose Delivered for External Beam Accelerated Partial Breast Irradiation Using Cone-Beam CT and Deformable Registration

Hasan, Yasmin; Kim, Leonard; Wloch, J.; Chi, Y; Liang, Jian; Martínez, Álvaro; Yan, Di; Vicini, Frank A.

doi:10.1016/j.ijrobp.2010.04.013

Cited by 23 publications

(12 citation statements)

References 20 publications

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“…19,21 For breast, the need for DIR validation is primarily driven by the interest in PBI and even for conformal boost (sequential or simultaneous integrated) with the published data indicating substantial interfraction mobility of the breast. 18,22 The recent publication of the external beam RAPID study indicates adverse cosmesis and late toxicity compared to whole breast irradiation may further motivate the need to reduce the volume of treated tissue via online DIR and adaptive radiotherapy approach. 23 Finally, given the trend toward multimodality treatment using minimally invasive techniques, a phantom that permits volumetric treatment preplanning (for radio and thermal therapy) and serves as a tool for training minimally invasive techniques under real-time image guidance was developed.…”

Section: Introductionmentioning

confidence: 99%

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions

et al. 2016

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“…Deformable image registration (DIR) has become increasingly critical in image-guided radiation therapy (IGRT). [1][2][3][4] For routine treatment planning, it is now very common to register MR or PET images with planning CT images for better tumor delineation. For image-guided adaptive radiotherapy, daily cone-beam CT (CBCT) images are usually fused with the planning CT image to verify the patient positioning, and planning contours are transferred to the CBCT or second planning CT image for adaptive treatment planning.…”

Section: Introductionmentioning

confidence: 99%

Site‐specific deformable imaging registration algorithm selection using patient‐based simulated deformations

et al. 2013

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QA for deformable image registration is essential to verify the cumulated dose for accurate adaptive radiotherapy. In this study, the authors develop a workflow that can validate image registration techniques for several different clinical sites and for various types of deformations using patient-based simulated deformations. This work could provide a reference for clinicians and radiation physicists on how to choose appropriate image registration algorithms for different situations.

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“…Studies of APBI, delivered with 3DCRT, have demonstrated daily variability in setup to skin marks ranging between 7–12mm (8, 17, 18). Similar results have been reported for treatment of intact breast cancer patients (16, 19).…”

Section: Discussionmentioning

confidence: 99%

An Image-Guided Study of Setup Reproducibility of Postmastectomy Breast Cancer Patients Treated With Inverse-Planned Intensity Modulated Radiation Therapy

Feng

Gerry

Chmura

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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Purpose/Objective(s) To calculate planning target volume (PTV) margins for chest wall and regional nodal targets using daily orthogonal kV imaging, and to study residual setup error after kV alignment using volumetric cone-beam computed tomography (CBCT). Methods and Materials Twenty-one post-mastectomy patients were treated with IMRT with 7mm PTV margins. Population-based PTV margins were calculated from translational shifts following daily kV positioning and/or weekly CBCT data for each of 8 patients, whose surgical clips were used as surrogates for target volumes. Errors from kV and CBCT data were mathematically combined to generate PTV margins for 3 simulated alignment workflows: 1) skin marks alone, 2) weekly kV imaging, 3) daily kV imaging. Results kV data from 613 treatment fractions indicated a 7mm uniform margin would account for 95% of daily shifts if patients were positioned using only skin marks. Total setup errors incorporating both kV and CBCT data were larger than those from kV alone, yielding PTV expansions of 7mm anterior-posterior (AP), 9mm left-right (LR), and 9mm superior-inferior (SI). Required PTV margins following weekly kV imaging were similar in magnitude as alignment to skin marks, but rotational adjustments of patients were required in 32%±17% of treatments. These rotations would have remained uncorrected without the use of daily kV imaging. Despite the use of daily kV imaging, CBCT data taken at the treatment position indicates that an anisotropic PTV margin of 6mm AP, 4mm LR, 8mm SI must be retained to account for residual errors. Conclusions CBCT provides additional information on three-dimensional reproducibility of treatment setup for chest wall targets. 3D data indicate that a uniform 7mm PTV margin is insufficient in the absence of daily IGRT. Inter-fraction movement is greater than suggested by two-dimensional imaging, thus a margin of at least 4–8mm must be retained despite the use of daily IGRT.

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Comparison of Planned Versus Actual Dose Delivered for External Beam Accelerated Partial Breast Irradiation Using Cone-Beam CT and Deformable Registration

Cited by 23 publications

References 20 publications

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions

Site‐specific deformable imaging registration algorithm selection using patient‐based simulated deformations

An Image-Guided Study of Setup Reproducibility of Postmastectomy Breast Cancer Patients Treated With Inverse-Planned Intensity Modulated Radiation Therapy

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