Comparison of Photochemotherapy and Dithranol in the Treatment of Chronic Plaque Psoriasis

Rogers, S.; Marks, Janet; Shuster, Sam; Briffa, Dino Vella; Warin, A P; Greaves, Malcolm W.

doi:10.1016/s0140-6736(79)90820-1

Cited by 105 publications

(52 citation statements)

References 11 publications

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“…11 In a large, randomized study from 1979 with well over 100 patients in each treatment arm, clearance was defined explicitly as "when all the lesions were flat and free of scales"; this was achieved in 91% and 82% of those who received psoralen photochemotherapy and dithranol, respectively. 12 More recently, "clearance" has tended to be qualified with phrases such as "clear or nearly clear" and "clear or minimal residual activity" to cater for those patients who may be left with a small residuum of psoriasis. 13 The UK National Institute of Health and Care Excellence (NICE) has further defined "minimal residual activity" as equivalent to greater than 90% reduction in PASI score.…”

Section: Psoriasis Assessment Tools: a Historical Perspectivementioning

confidence: 99%

Assessing Psoriasis Severity and Outcomes for Clinical Trials and Routine Clinical Practice

Chalmers

2015

Dermatologic Clinics

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Section: Psoriasis Assessment Tools: a Historical Perspectivementioning

confidence: 99%

Assessing Psoriasis Severity and Outcomes for Clinical Trials and Routine Clinical Practice

Chalmers

2015

Dermatologic Clinics

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“…The photosensitiz er (8 methoxy-psoralen) was administered 2 h before UVA exposure at a dose of 0.6 mg/kg bodyweight. The initial starting dose of UVA had to be based on skin type [17], i.e. 2 J/cm2 in skin type 2 and 3 J/cm2 in skin type 3.…”

Section: Treatmentmentioning

confidence: 99%

Randomized Double-Blind Multicenter Study Comparing Acitretin-PUVA, Etretinate-PUVA and Placebo-PUVA in the Treatment of Severe Psoriasis

Saurat

Geiger²,

Amblard³

et al. 1988

Dermatology

133

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A randomized double-blind study was designed with 65 patients in order to clarify two points: (1) does addition of a retinoid to psoralen-ultra violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to placebo-PUVA with respect to several items (decrease in lesional scores after 6 weeks of therapy, number of PUVA exposures, and total dose of UVA until remission). There were also differences between the etretinate-PUVA and placebo-PUVA groups, but only the decrease in lesional scores reached statistical significance.

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“…Dithranol (anthralin) has been the main stay of topical treatment of psoriasis for over 65 years and still is one of the most effective antipsoriatic drugs [Rogers et al, 1979], Dithranol has mostly been used in paste for mulations which are messy and unsuitable for application at home. The common side effects, irritation and staining of the skin and clothing, have restricted its use mainly to hospitals.…”

mentioning

confidence: 99%

Ambulatory Treatment of Psoriasis with Dithranol Sticks A Novel Paraffin Formulation

1985

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The efficacy and tolerability of a novel stiff dithranol stick (Ditrastick®, Orion, Espoo, Finland) were evaluated in an open multicenter trial comprising 121 outpatients with limited psoriasis of the plaque type. Daily treatment was startet with 1.5% dithranol sticks and continued in most patients with 3% sticks after 2 weeks. An excellent or good result was obtained in over half of the patients. Early irritation of a rather narrow rim of the skin surrounding the lesions was common, but only about 10% of the patients discontinued the trial due to this side effect. Paraffin-based dithranol sticks thus enable ambulatory treatment of chronic plaque psoriasis in the areas of predilection. Dithranol is stable in this novel preparation for at least 3 years.

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Comparison of Photochemotherapy and Dithranol in the Treatment of Chronic Plaque Psoriasis

Cited by 105 publications

References 11 publications

Assessing Psoriasis Severity and Outcomes for Clinical Trials and Routine Clinical Practice

Assessing Psoriasis Severity and Outcomes for Clinical Trials and Routine Clinical Practice

Randomized Double-Blind Multicenter Study Comparing Acitretin-PUVA, Etretinate-PUVA and Placebo-PUVA in the Treatment of Severe Psoriasis

Ambulatory Treatment of Psoriasis with Dithranol Sticks A Novel Paraffin Formulation

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