Ambulatory Treatment of Psoriasis with Dithranol Sticks A Novel Paraffin Formulation

Brandt, Hebert Roberto Clivati; Gordin, A.; Mustakallio, K. K.

doi:10.1159/000249473

Cited by 3 publications

(4 citation statements)

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“…In 63 % butantrone and in 73 % dithranol gave a good therapeutic result. This is in accordance with the previous study on Ditrastick (7), in which about 70% of patients achieved an excellent or good result.…”

Section: Discussionsupporting

confidence: 93%

“…Because of repeated irritations dithranol had to be discontinued in 23 % of patients. In the previous study on Ditrastick (7), about 21 % of patients discontinued the treatment because of inefficacy or side effects.…”

Section: Discussionmentioning

confidence: 98%

“…The Finnish dithranol stick, Ditrastick®, is based on a mixture of three paraffins, a formulation in which dithranol is stable without any antioxidants (8). However, even in this stick formulation the side effects of dithranol still persist, although milder than with convention al dithranol pastes (7).…”

mentioning

confidence: 88%

“…Increasing costs of hospital care has made it necessary to look for other alternatives and to develop ambulatory treatment regimens usable at home and day care treatment centers (3). Dithranol cream (4,5) and stick (6,7) formulations serve that purpose, making this antipsoriatic drug better acceptable for treatment at home. The Finnish dithranol stick, Ditrastick®, is based on a mixture of three paraffins, a formulation in which dithranol is stable without any antioxidants (8).…”

mentioning

confidence: 99%

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Antipsoriatic activity of 10-acyl analogues of dithranol (anthralin). II. Clinical comparison of dithranol and butantrone sticks with special reference to side effects

Brandt

1987

Acta Derm Venereol

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Thirty outpatients with limited (under 15% of skin area affected), symmetrical psoriasis of the plaque type were included in an open, right-left comparison study. Paraffin-based, 3% dithranol sticks (Ditrastick, Orion Pharmaceutica, Espoo, Finland) and similar, equimolar 4% butantrone sticks were used. Antipsoriatic activity, staining of the skin and clothes and irritation were the parameters followed up. An overall evaluation was made at the end of the trial. The antipsoriatic activity of dithranol and butantrone was almost equal at equimolar concentrations. Staining of the skin was significantly (at least p less than 0.05) milder with butantrone after 2 to 10 weeks treatment. Staining of clothes was less on the butantrone side for up to three months of use but was thereafter similar to that of dithranol. Irritation caused by butantrone reached its maximum only after 6 to 10 weeks and remained on average below the level of initial dithranol irritation. Six patients discontinued the treatment due to irritation by both preparations. Four patients tolerated better dithranol than butantrone. One patient could not use dithranol but cleared with butantrone. Thus, even if butantrone has an antipsoriatic efficacy almost equal to that of dithranol and is less staining than dithranol, it causes in some patients slowly increasing irritation with Koebner-like deterioration of the disease after some weeks of uneventful overnight use.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 88%

mentioning

confidence: 99%

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