Comparison of Phenylephrine and Ephedrine in Treatment of Spinal-Induced Hypotension in High-Risk Pregnancies: A Narrative Review

Dusitkasem, Sasima; Herndon, Blair H.; Somjit, Monsicha; Stahl, David; Bitticker, Emily; Coffman, J.C.

doi:10.3389/fmed.2017.00002

Cited by 22 publications

(21 citation statements)

References 44 publications

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“…Specifically, the absence of adrenergic receptor binding of p -synephrine provides the explanation for its lack of production of harmful cardiovascular effects as compared to m -synephrine. Hence, while m -synephrine can be considered as an alkaloid with a potent cardiovascular effect [ 12 ], p -synephrine or Citrus aurantium intake are normally not associated to harmful cardiovascular events [ 13 ].…”

Section: Chemical Structure Of P -Synephrinementioning

confidence: 99%

Effects of p-Synephrine during Exercise: A Brief Narrative Review

et al. 2021

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The p-synephrine is the principal phytochemical found in bitter orange (Citrus aurantium). This substance is widely included in dietary supplements for weight loss/body fat reduction due to its potential benefits of increasing fat oxidation. For years, p-synephrine-containing dietary supplements have been marketed without proper knowledge of their true effectiveness to enhance fat utilization, especially when combined with exercise. However, the effects of p-synephrine on fat oxidation during exercise have been investigated in the last few years. The aim of the current discussion is to summarize the evidence on the effects of p-synephrine intake on fat oxidation and performance during exercise. Previous investigations have demonstrated that the acute intake of p-synephrine does not modify running sprint performance, jumping capacity, or aerobic capacity. However, the acute intake of p-synephrine, in a dose of 2–3 mg/kg of body mass, has been effective to enhance the rate of fat oxidation during incremental and continuous exercise. This effect has been observed in a range of exercise workloads between 30% and 80% of peak oxygen uptake (VO2peak). The p-synephrine has the ability to increase the maximal rate of fat oxidation during exercise of increasing intensity without affecting the workload at which maximal fat oxidation is obtained (Fatmax). The effect of p-synephrine on fat oxidation is normally accompanied by a concomitant reduction of carbohydrate utilization during exercise, without modifying the energy expended during exercise. The shifting in substrate oxidation is obtained without any effect on heart rate during exercise and the prevalence of adverse effects is negligible. Thus, the acute use of p-synephrine, or p-synephrine-containing products, might offer some benefits for those individuals seeking higher fat utilization during exercise at low to moderate intensities. However, more research is still necessary to determine if the effect of p-synephrine on fat oxidation during exercise is maintained with chronic ingestion, in order to ascertain the utility of this substance in conjunction with exercise programs to produce an effective body fat/weight loss reduction.

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Section: Chemical Structure Of P -Synephrinementioning

confidence: 99%

Effects of p-Synephrine during Exercise: A Brief Narrative Review

et al. 2021

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“…However, in previous studies (2,8,11,(24)(25)(26)(27)(28)(29) no differences were seen between the 2 groups of phenylephrine and ephedrine in terms of fetal acidosis.…”

Section: Discussionmentioning

confidence: 86%

Comparing Intravenous Phenylephrine and Ephedrine for Hypotension During Spinal Anesthesia for Elective Cesarean Section: A Randomized Double-Blind Clinical Trial

Vakili¹,

Enayati²,

Dashipour³

2017

Iran Red Crescent Med J

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“…This has led to an emphasis on non-pharmacological approaches to the management of hypotension and the introduction of ephedrine as a selective vasopressant for obstetric patients. However, recent medical findings have questioned conventional education and have had a profound impact on how we respond to hypotension under spinal anesthesia during labor [11].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Hypotension in Lateral Verses Sitting Positions during Induction of Spinal Anaesthesia for Caesarean Section

Arshed

Khatoon²,

Nadeem

et al. 2021

JPRI

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Objective: To compare the hypotension in lateral verses sitting positions during induction of spinal anaesthesia for caesarean section. Study Design: This is a Randomized control trial (RCT) study. Setting: Study carried out at Department of Anaesthesiology, Surgical Intensive Care Unit and Pain Management, Civil Hospital, Dow University of health sciences Karachi, from December 2018 to June 2019. Materials and Methods: All women age 18 to 45 underwent elective caesarian section having ASA I and II, singleton pregnancy on ultrasound with parity ≤3 were enrolled. Patients were randomized to receive spinal anaesthesia in the lateral position (Group L) or the sitting position (Group S) through lottery methods. Using the L3-4 interspace, patients received intrathecal plain bupivacaine, 10mg or 12 mg according to their height, after which they was placed immediately in the supine position with left uterine displacement. Maternal blood pressure was measured with the help of Non-invasive BP apparatus. BP was recorded at baseline then every 5 min till 30 minutes by anesthetist who was unaware of parturient group. Any single or more reading of SBP of <90 mmHg was considered as Hypotension. Results: Mean age of the patients in lateral group was 31.49 ±10.87 years and mean age of the patients in sitting group was 31.80 ±10.77 years (p-value 0.869). Majority of the patients 35 (62.5%) with hypotension were presented with sitting position. Chi square test was applied and statistically significant difference was observed between groups (p-value 0.012). Conclusion: We concluded that less frequency of hypotension was observed when spinal anaesthesia for caesarean section using plain bupivacaine in the lateral position.

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Comparison of Phenylephrine and Ephedrine in Treatment of Spinal-Induced Hypotension in High-Risk Pregnancies: A Narrative Review

Cited by 22 publications

References 44 publications

Effects of p-Synephrine during Exercise: A Brief Narrative Review

Effects of p-Synephrine during Exercise: A Brief Narrative Review

Comparing Intravenous Phenylephrine and Ephedrine for Hypotension During Spinal Anesthesia for Elective Cesarean Section: A Randomized Double-Blind Clinical Trial

Comparison of the Hypotension in Lateral Verses Sitting Positions during Induction of Spinal Anaesthesia for Caesarean Section

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