Comparison of Ph-Adjusted Bupivacaine With a Mixture of Non-Ph-Adjusted Bupivacaine and Lignocaine in Primary Vitreoretinal Surgery

Sharma, Tarun; Gopal, Lingam; Shanmugam, Mahesh P; Bhende, Pramod; George, Joshua; Samanta, Tapan Kumar; Mukesh, Bickol N.

doi:10.1097/00006982-200204000-00011

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Sharma et al 38 investigated the efficacy of alkalinised bupivacaine compared with a mix of non-alkalinised bupivacaine and lignocaine in 540 vitreoretinal surgery patients using peribulbar blocks. The trial showed pH adjustment of bupivacaine and hyaluronidase provided greater efficacy, less intra-operative pain, lower frequency of intra-operative supplementation and a decreased occurrence of postoperative pain in the first 24 h compared with the non-adjusted lignocaine/bupivacaine/hyaluronidase mix.…”

Section: Bicarbonate Buffering Of Local Anaesthesia and Hyaluronidasementioning

confidence: 99%

Adjuvants to local anaesthesia in ophthalmic surgery

Adams

2011

British Journal of Ophthalmology

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This article reviews the use of adjuvants to local anaesthesia for ophthalmic regional anaesthesia. Hyaluronidase, bicarbonate, epinephrine, muscle relaxants, opiates and clonidine have all been described singly and in combination for use as an adjuvant to ophthalmic regional anaesthesia. The article focuses on the efficacy of the adjuvants with regard to improving akinesia, analgesia, speed of onset and reducing block failure. A description of the pharmacological action of each adjuvant is given followed by a review of randomised control trials, dosage and notable papers on the subject. There is no effective consensus between anaesthetists or surgeons on the use of adjuvants to local anaesthesia and it so is the purpose of this review to draw attention to the wealth of current data and allow an informed decision on the choices available.

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Section: Bicarbonate Buffering Of Local Anaesthesia and Hyaluronidasementioning

confidence: 99%

Adjuvants to local anaesthesia in ophthalmic surgery

Adams

2011

British Journal of Ophthalmology

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“…It provides the same anaesthetic effect as a retrobulbar injection, but has a lower rate of complications (Davis & Mandel 1994). The extraconal peribulbar technique is considered preferable over the retrobulbar technique for delivering local anaesthetic (LA) agents in ophthalmic surgery (Sharma et al. 2002).…”

Section: Introductionmentioning

confidence: 99%

Comparison of a bupivacaine 0.5% and lidocaine 2% mixture with levobupivacaine 0.75% and ropivacaine 1% in peribulbar anaesthesia for cataract surgery with phacoemulsification

Borazan

Karalezlı

Oto

et al. 2007

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To compare a bupivacaine and lidocaine mixture with levobupivacaine and ropivacaine in terms of safety, efficacy and blocking quality in peribulbar anaesthesia for phacoemulsification. Methods: A total of 105 patients scheduled for cataract surgery with peribulbar anaesthesia were randomly allocated into three groups of 35 patients each, to receive 5 ml of, respectively, a 1 : 1 mixture of bupivacaine 0.5% and lidocaine 2% (group 1), levobupivacaine 0.75% (group 2), or ropivacaine 1% (group 3). Ocular movement scores were evaluated at 2, 4, 6, 8 and 10 mins after injection. Intraoperative and postoperative analgesia were evaluated by verbal pain scores. Duration of surgery, need for supplementary anaesthesia, haemodynamic parameters and the incidence of perioperative complications were recorded. Results: The ocular movement score in min 2 was significantly lower in group 1. There was no significant difference between groups 2 and 3. Ocular movement scores at mins 4 and 6 were significantly decreased in group 1 and 2 compared with group 3. There was no significant difference among the groups in ocular movement scores at mins 8 and 10. Verbal pain scores in postoperative hour 4 were highest in group 3, but scores for the intraoperative period and postoperative hours 1 and 2 were similar among the groups. Duration of surgery and haemodynamic parameters did not differ among the groups. Conclusions: All agents were considered to be convenient for clinical use in cataract surgery with peribulbar anaesthesia. Although the ocular movement scores in the ropivacaine group were higher than in the other groups at mins 4 and 6, this did not imply any clinical significance.

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