Comparison of periodontal and peri-implant inflammatory parameters among patients with prediabetes, type 2 diabetes mellitus and non-diabetic controls

Abduljabbar, Tariq; Al-Sahaly, Faisal; Al-Kathami, Mohammed; Afzal, Sibtain; Vohra, Fahim

doi:10.1080/00016357.2017.1303848

Cited by 53 publications

(51 citation statements)

References 23 publications

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“…The overall success certainly depends on a number of factors including oral hygiene care, smoking, and smokeless tobacco use, chronic systemic inflammatory response such as obesity and type‐2 diabetes mellitus (T2DM) . Chronic hyperglycemia is considered as a typical risk‐factor that causes soft tissue inflammation and RBL around natural teeth and implants . One possible explanation for this mechanism is that chronic hyperglycemia has the propensity to increase the levels of accumulated glycation end products (AGEs) in the serum and oral tissues that accelerates the production of proinflammatory cytokines that induce bone destruction around natural teeth and implants .…”

Section: Introductionmentioning

confidence: 99%

Clinical and radiographic peri‐implant variables around short dental implants in type 2 diabetic, prediabetic, and non‐diabetic patients

Mokeem

Alfadda

Al‐Shibani

et al. 2018

Clin Implant Dent Rel Res

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Background Clinical and radiographic status around short dental implants in patients with different glycemic levels remains unexplored. Purpose To determine the clinical and radiographic bone level (RBL) around short dental implants in type‐2 diabetes mellitus (T2DM), prediabetic, and non‐diabetic patients. Materials and Methods Participants were grouped into three groups based on HbA1c levels: T2DM (Group‐1); prediabetic patients (Group‐2); and non‐diabetic subjects (Group‐3). Clinical recordings included the assessment of peri‐implant plaque index (PI), bleeding on probing (BOP), probing depth (PD). Radiographic analysis included evaluation of standardized periapical digital radiographs using specialized software and image analyzer. Results Clinical peri‐implant parameters including PI and BOP were statistically significantly higher in group‐1 (P < .01) and group 2 (P < .05) as compared to group‐3. Mean PD was statistically significantly higher in group‐1 patients compared to group‐3 (P < .01). Radiographic bone loss was significantly higher in both group‐1 (P < .01) and group‐2 (P < .05) patients as compared to patients in group 3. RBL showed statistically significant difference among T2DM patients even after adjusting for HbA1c, total cholesterol, and body mass index (P < .05) and statistically significant difference in prediabetic patients after adjusting for only HbA1c (P < .05). Conclusion Clinical and radiographic peri‐implant parameters are compromised around short dental implants in type‐2 diabetes mellitus patients. Further longitudinal studies are needed to compare clinical performance of short dental implants with standard dental implants placed in patients with different glycemic level.

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Section: Introductionmentioning

confidence: 99%

Clinical and radiographic peri‐implant variables around short dental implants in type 2 diabetic, prediabetic, and non‐diabetic patients

Mokeem

Alfadda

Al‐Shibani

et al. 2018

Clin Implant Dent Rel Res

Self Cite

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show abstract

“…10 Similarly, results from a recent 24-month study showed that dental implants can remain clinically and radiographically stable in T2DM patients in a manner that is similar to that observed in non-diabetic (NT2DM) individuals. 11,12 However, these studies were conducted for a short follow-up period and, therefore, studies with a longer follow-up period may help to elucidate peri-implant outcomes and stability of dental implants in T2DM as compared to NT2DM patients. Thus, the aim of the present 7-year prospective observational study was to evaluate peri-implant bone loss (PIBL) and stability around submerged and non-submerged dental implants in T2DM and NT2DM patients.…”

Section: Introductionmentioning

confidence: 99%

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Zahrani

Mutairi

2018

Braz. oral res.

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Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up Abstract: To evaluate peri-implant bone loss (PIBL) and stability around submerged and non-submerged dental implants in patients with and without type 2 diabetes mellitus (T2DM). Thirty-five T2DM and non-diabetic (NT2DM) patients were included in this study. Demographic data were recorded using a questionnaire and PIBL was measured on digital radiographs. Resonance frequency analysis (RFA) was carried out for each implant at the time of fixture placement and at 3 months in both groups. P values less than 0.05 were considered statistically significant. One hundred and eighteen dental implants with a mean height of 10 to 12 mm and 3.3 to 4.1 mm in diameter were placed. The comparison of the mean RFA values at baseline and at 3 months was statistically significant (p = 0.008) in T2DM patients. The inter-group mean RFA values at baseline and at 3 months were not significant (p > 0.05). PIBL was significantly high in T2DM as compared to NT2DM patients at each follow-up (p < 0.05). At 2, 3, and 7 years, non-submerged dental implants showed significantly high PIBL in T2DM patients as compared to NT2DM individuals (p<0.05). The results of the present clinical study demonstrate increased PIBL around non-submerged single-tooth implant-supported restorations in T2DM patients, which may be due to the immune inflammatory status.

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“…28 In light of these evidences, it may be postulated that peri-implant soft and hard tissue show inflammatory response Covariates were simultaneously adjusted for all variables. 33,34 However, the effect of FBGL levels on peri-implant inflammation in obese patients were controlled (through step-wise logistic regression analysis). It is well documented that chronic hyperglycemia is associated with excessive formation of accumulated glycation end products (AGEs) and its receptors (RAGEs) in the tissues.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Alkhudhairy

Vohra

Al‐Kheraif

et al. 2018

Clin Implant Dent Rel Res

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Comparison of periodontal and peri-implant inflammatory parameters among patients with prediabetes, type 2 diabetes mellitus and non-diabetic controls

Abstract: Periodontal and periimplant inflammatory parameters were worse among patients with prediabetes and T2DM compared with controls; however, these parameters were comparable among patients with prediabetes and T2DM.

Cited by 53 publications

References 23 publications

Clinical and radiographic peri‐implant variables around short dental implants in type 2 diabetic, prediabetic, and non‐diabetic patients

Clinical and radiographic peri‐implant variables around short dental implants in type 2 diabetic, prediabetic, and non‐diabetic patients

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

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