Comparison of pericranium and eggshell as space fillers used in combination with guided bone regeneration: An experimental study

The effects of guided tissue regeneration (GTR) on modified Le Fort I osteotomy healing in rabbits

“…The tissuetypes found in uncovered defects in the present study were fibrous and loose connective tissue that appeared to be running vertically up from the palatal mucosa. The only bone healing in uncovered defects appeared to come from the lateral margins of the defect, which would be consistent with osteogenic cells being derived from the adjacent periosteum of the surrounding bony margins 7,12-15,19-22 . These results suggest that the use of a collagen membrane was effective in hindering the migration of fibrous tissue into the defect, and are consistent with findings from previous studies also using other GTR membranes [4][5][6][7]9,[11][12][13][14][15][17][18][19][20][21][22][23][24] . However, bony wound healing at four weeks postoperatively in the present study was not as dramatic as expected and compared to our previous study, where the maxillary osteotomy was smaller and the maxilla was not mobilized 22 .…”

“…However, it is not clear whether the uncovered defects would have healed better given more time and this point needs to be investigated. It has been suggested that the biological basis of GTR is that tissues found in the wound site during the healing phase will determine the resultant type of tissue that replaces the clot [4][5][6][7]9,[11][12][13][14][15][17][18][19][20][21][22][23][24] . Therefore, allowing fibrous tissue to repopulate the defect site first will impede osteogenesis and result in fibrous tissue dominating the defect area.…”

“…In a variety of experimental and clinical applications, barrier membranes were utilized to enhance wound healing such as extraction sockets, periapical defects, periodontal defects, implant dehiscences, small osteotomy sites, and prevention of peridural fibrosis after spinal surgery [4][5][6][7]9,[11][12][13][14][15][17][18][19][20][21][22][23][24] . Independent of ongoing discussions and controversies on the utility of barrier membranes the following question was formulated: Can Guided tissue regeneration (GTR) work on a much larger osteotomy defect where there is a functional load present such as in a Le Fort procedure?…”

Histologic and histomorphometric assessment of eggshell-derived bone graft substitutes on bone healing in rats

“…For example, avian and/or ostrich eggshell has been recently introduced in the field of dentistry (14-18,20,22,25). In this study, hen’s eggshell was proposed as a graft material due to its biocompatibility; the chemical contents of eggshell-derived CaCO3 are likely to host the chemical structure of bone as well.…”

Preparation and characterization of a novel bone graft composite containing bone ash and egg shell powder

“…It is reported that 1,90,000 tonnes of egg shell is wasted in India and might be used as a calcium source in human nutrition (Schaafsma et al 2000). The biological behaviour of this natural material has * Author for correspondence (sastrytp@hotmail.com) also shown that it could be used as a bone substitute in the field of maxillofacial surgery (Dupoirieux et al 1995(Dupoirieux et al , 2000(Dupoirieux et al , 2001Dupoirieux 1999). Egg shell particles ranging from 400-600 μm were bioassayed in the intramuscular pouches of rodents and their osteoinductive nature studied.…”