Comparison of percutaneous permeation profiles of flurbiprofen enantiomers

Zhang, Lijing; Xie, Jiao; Liu, Cheng; Sun, Yinghua; Zhang, Peng

doi:10.1002/chir.23441

Cited by 3 publications

(2 citation statements)

References 31 publications

(38 reference statements)

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“…In this experiment, a horizontal dual-chamber diffusion cell (effective diffusion area of 0.95 cm 2 ) was used to study the transdermal permeability of the cataplasm [24]. The ex vivo skin samples were thawed, washed with saline and dried with lter paper.…”

Section: In Vitro Percutaneous Permeation Studymentioning

confidence: 99%

Design of a novel felbinac cataplasm with high permeability for the treatment of arthritis

Liu

Bai

Zhao

et al. 2023

Preprint

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The purpose of this study was to design a novel felbinac cataplasm with higher permeability than commercial product SELTOUCH® through using chemical enhancer strategy to reduce the times of administration and improve the compliance of patients. The novel felbinac cataplasm with high adhesion and good biocompatibility was prepared by calendar coating method. On the basis of previous research, the high-performance liquid chromatography (HPLC) analytical method of felbinac was established. According to 2020 Chinese pharmacopoeia (Ch. P), the paddle plate method was used to study the in vitro dissolution. The results showed the release of drug from self-made felbinac cataplasm could reach 90%. Subsequently, the effects of different kinds of penetration enhancers (N-methylpyrrolidone (NMP), isopropyl myristate (IPM) and propylene glycol (PG)) with the same percentage on the penetration of felbinac cataplasm were investigated. Propylene glycol (PG) was proved to be the most effective permeation enhancer among them. After screening different percentages of PG, 1% was added as the amount of permeation enhancer and the 12 h cumulative permeation amount was 189.03 µg/cm2 which was two times of the reference cataplasm (94.44 µg/cm2). The self-made felbinac cataplasm also had good stable permeability after placing at room temperature for 4 months. Finally, the tissue distribution study showed no matter in plasma, skin or muscle, the drug concentration of self-made cataplasm group was higher than reference cataplasm group. These data indicated that the self-made cataplasm provided a new reference for the development of felbinac dosage forms and promising alternative strategy for arthritis therapy.

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Section: In Vitro Percutaneous Permeation Studymentioning

confidence: 99%

Design of a novel felbinac cataplasm with high permeability for the treatment of arthritis

Liu

Bai

Zhao

et al. 2023

Preprint

Self Cite

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“…However, in vitro studies on rat abdominal skin at different pH and chemical penetration promoters showed that there appeared to be no difference in the penetration ability of S‐flurbiprofen and flurbiprofen racemate (R‐flurbiprofen). [ 221 ] This also provides some experience for the future treatment of OA by transdermal administration of the chiral compound flurbiprofen. In addition, the potential role of supramolecular chirality in biology and nanomedicine is also worth to be explored.…”

Section: Nanomaterials Properties and Responsive Systems For Treating Oamentioning

confidence: 99%

Analysis of Nanomedicine Efficacy for Osteoarthritis

Wang

Liu

et al. 2022

Advanced NanoBiomed Research

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Osteoarthritis (OA) is a chronic disease and it causes considerable medical and socioeconomic burden. Currently, OA can be classified into different stages depending on its severity, from mild to severe, but there is no treatment focusing on a particular stage. In addition, conventional treatments suffer from drawbacks such as the poor effectiveness of physiotherapy, short‐term efficacy of medication, and invasiveness of surgery. Nanomedicine is a promising approach to improve OA treatments such as by prolonging the residence time of drugs in the joint and on‐demand drug release. Herein, the pathological development of OA and the cellular involvement in this process is reviewed and classified into three stages: early, intermediate, and advanced, according to its pathology and severity. Subsequently, nanomaterials that have been used to deliver drug cargo relevant to different stages of OA are reviewed. The impact of nanomaterial physicochemical properties, on therapeutic efficacy, is discussed. This is concluded by discussing the significance of minimum information reporting to standardize the use of nanomedicine for OA treatment and the potential of emerging methods including microneedles and DNA barcoding technology to improve the understanding of OA biology and improve clinical translation.

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Rapidly separable microneedle patch for the controlled and sustained release of 5-fluorouracil

Zhang

Yin

et al. 2023

International Journal of Pharmaceutics

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Comparison of percutaneous permeation profiles of flurbiprofen enantiomers

Cited by 3 publications

References 31 publications

Design of a novel felbinac cataplasm with high permeability for the treatment of arthritis

Design of a novel felbinac cataplasm with high permeability for the treatment of arthritis

Analysis of Nanomedicine Efficacy for Osteoarthritis

Rapidly separable microneedle patch for the controlled and sustained release of 5-fluorouracil

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