Rapidly separable microneedle patch for the controlled and sustained release of 5-fluorouracil

Zhang, Lijing; Lv, Jiatong; Yin, Yannan; Ling, Guixia; Zhang, Peng

doi:10.1016/j.ijpharm.2023.122730

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…where C t is similar to that mentioned above, and α = 1/(C max ) 2 .k rel, β = 1/C max , and r 0 = 1/k rel . The intercept and slope of the t/C t versus t plot were used to determine values of α and β, respectively.…”

Section: Drug Releasementioning

confidence: 99%

“…Consequently, high doses are required, which can lead to potential adverse effects. [2,3] To ensure the effective and safe delivery of 5-FU, the carrier must fulfill specific requirements. First, biocompatibility and biodegradability are crucial attributes as they minimize potential toxicity and adverse effects within the body.…”

Section: Introductionmentioning

confidence: 99%

“…Due to its low selectivity and short half‐life in blood and tissues, 5‐FU is often administered multiple times intravenously or orally throughout the day. Consequently, high doses are required, which can lead to potential adverse effects [2,3] …”

Section: Introductionmentioning

confidence: 99%

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A Novel Carrier Based on DNA and Exosome to Sustained Release of 5‐Fluorouracil Anticancer Drug

Oraki,

Saeidifar,

Khanlarkhani

et al. 2024

ChemistrySelect

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The development of effective drug delivery systems is crucial for improving cancer treatment outcomes. A promising carrier using a combination of DNA and exosomes (EXO) was synthesized to sustain the release of the powerful anticancer drug 5‐fluorouracil (5‐FU). The carrier was prepared by encapsulating 5‐FU‐loaded exosomes (5‐FU.EXO) in the heated DNA carriers (5‐FU.EXO@DNA). Alteration of the DNA structure was studied using molecular dynamics. The physicochemical properties of the carriers were characterized using fourier‐transform infrared spectroscopy (FTIR), field‐emission scanning electron microscopy (FESEM), and dynamic light scattering (DLS). The 5‐FU.EXO@DNA carrier exhibited good stability and biocompatibility, with a uniform size distribution (709±269 nm) and a zeta potential of +312 mV. The interaction between 5‐FU and DNA was confirmed using molecular docking. In vitro release studies showed that both 5‐FU@DNA and 5‐FU.EXO@DNA carriers achieved sustained release of 5‐FU for 576 h, with cumulative releases of approximately 83 % and 89 %, respectively. The 5‐FU release profile showed 40 % release over 86 h. The release rate and other kinetic parameters were also determined. Furthermore, the release kinetics followed by the Korsmeyer‐Peppas model and the diffusion mechanism plays a significant role in controlling the release process.

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Section: Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Carrier Based on DNA and Exosome to Sustained Release of 5‐Fluorouracil Anticancer Drug

Oraki,

Saeidifar,

Khanlarkhani

et al. 2024

ChemistrySelect

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show abstract

“…Moreover, microneedles can be used as a single drug carrier or combined with other types of drug carriers for co-delivery, such as vesicles, [14][15][16][17] exosomes, [18][19][20] micelles, 21,22 liposomes, [23][24][25][26] microspheres, 27 and nanoparticles. [28][29][30] Microneedles have been used for delivering various drugs, including small molecule drugs, [31][32][33] nucleic acids, 34 proteins, 35 and biologically active drugs such as cells, 36 bacterias, 37 and viruses. 38 Appropriate matrix materials should be selected based on the physicochemical and biological properties of the drug for immediate release, sustained release, or controlled release.…”

Section: Xiyu Liumentioning

confidence: 99%

“…Moreover, microneedles can be used as a single drug carrier or combined with other types of drug carriers for co-delivery, such as vesicles, 14–17 exosomes, 18–20 micelles, 21,22 liposomes, 23–26 microspheres, 27 and nanoparticles. 28–30…”

Section: Introductionmentioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

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Wounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

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Rapidly separable microneedle patch for the controlled and sustained release of 5-fluorouracil

Cited by 9 publications

References 40 publications

A Novel Carrier Based on DNA and Exosome to Sustained Release of 5‐Fluorouracil Anticancer Drug

A Novel Carrier Based on DNA and Exosome to Sustained Release of 5‐Fluorouracil Anticancer Drug

Applications and prospects of microneedles in tumor drug delivery

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

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