Comparison of patch test results with a standard series among white and black racial groups

Taylor, James S.; Evey, Phyllis

doi:10.1053/ajcd.2001.20110

Cited by 28 publications

(20 citation statements)

References 31 publications

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“…Few reactions were found to colophony and balsam of Peru. These figures are in line with a previous study from Denmark (1,25), however, lower than reported in out-patient clinic studies (18,28). Moreover, there does not seem to be a concomitant positive patch test to balsam of Peru in fragrance-sensitive patients, which suggests that balsam of Peru is not a reliable marker of fragrance allergy (27).…”

Section: Discussionsupporting

confidence: 89%

The prevalence of allergic contact sensitization in a general population in Tromso, Norway

Dotterud

2007

International Journal of Circumpolar Health

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Objectives. This study investigated the prevalence of contact sensitization in a general adult population and the relationship between the history of metal dermatitis and sensitization to metal allergens. Study design. A cross-sectional population study using patch tests and a questionnaire was conducted among adults in Tromsø, Northern Norway. Methods. A random sample of 830 participants aged 18-75 years were invited to participate in the patch testing and completed a 1-page self-administered questionnaire. Of the adults, 531 (64%) were actually TRUE tested (using a standardized, ready-to-apply patch test system) and completed the self-administered questionnaire about ear piercing, metal reactions, skin reactions to different allergens, atopic dermatitis, eczema, cooking equipment and diet. Results. The study showed that nickel (19.2%; women 31.1% and men 5.0%), fragrance mix (3.4%) and cobalt (1.7%) were the most prevalent allergens causing contact sensitization. For all other allergens, less than 1.1% tested positive. Eighty-four (45.2%) subjects with a positive history of metal dermatitis had negative patch tests. Conclusions. Contact sensitization was found frequently in this general adult population, especially to nickel and perfumes with a predominance among females. An eczematous reaction caused by cheap earrings seemed to be the best indicator for metal sensitivity.

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Section: Discussionsupporting

confidence: 89%

The prevalence of allergic contact sensitization in a general population in Tromso, Norway

Dotterud

2007

International Journal of Circumpolar Health

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“…No association was found between positive patch test results and acetylator status although it was reported that variations in N-acetylation in human skin could account for variations in positivity in patch testing. 10 In a parallel study of the acetylator status among children with atopic dermatitis, an association was found between the severity and site of the atopic dermatitis and acetylator status. 11 However, in this study no such association was found.…”

Section: Discussionmentioning

confidence: 98%

“…Statistical analyses were done using SPSS version. 10 Differences between groups were assessed by the chi-square test. An estimate was considered statistically significant if the P value was <0.05.…”

Section: Methodsmentioning

confidence: 99%

Acetylator phenotype in Iraqi patients with allergic contact dermatitis

Najim

Al-waizt

Al-Razzuqi

2005

Annals of Saudi Medicine

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BACKGROUNDFew studies have been done on acetylator status in ACD. This study determined acetylator status in Iraqi patients with allergic contact dermatitis (ACD) in comparison to a matched control group.PATIENTS AND METHODSThe study included 35 ACD patients and 67 healthy volunteers. The ACD patients were diagnosed clinically and the diagnosis was confirmed by patch test. A detailed history was taken from the patients. After an overnight fast, each control subject and each patient received a single oral dose of 100 mg of dapsone. A blood sample was collected after 3 hours and plasma was separated for determination of dapsone and monoacetyldapsone by HPLC.RESULTSTwenty-six of the 35 ACD patients returned for follow up. The frequency of slow acetylators in healthy individuals was 71.6%, while the frequency of rapid acetylators was 28.4%. The frequency of slow acetylators in ACD patients was 60.0% while the frequency of rapid acetylators was 40.0%. There was no association between the acetylator status, personal history of allergy, patch-test positivity or sites of dermatitis in ACD patients.CONCLUSIONA rapid acetylator status might predispose to ACD, but does not seem to influence other features of the disease.

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“…Allergic or photoallergic contact dermatitis is found in roughly 70% of those with CAD with sunscreen components usually implicated . Para‐phenylenediamine, a known dye allergen, is suggested as a potential sensitizer seen more frequently in patients with SOC . This is believed to be due to exposure to products, such as hair care products, with higher levels of para‐phenylenediamine, which could lead to increased sensitization rates …”

Section: Immune‐mediated Photodermatosesmentioning

confidence: 99%

Photodermatoses in skin of colour

Gutiérrez

Gaulding

Beltran

et al. 2018

Acad Dermatol Venereol

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Photodermatoses represent a heterogeneous collection of disorders unified by the characteristic of being provoked through exposure to ultraviolet radiation. Generally, these conditions are classified into the following categories: immunologically mediated photodermatoses, chemical- and drug-induced photosensitivity, photoaggravated dermatoses and photosensitivity associated with defective DNA repair mechanisms or chromosomal instabilities. The list of photodermatoses is extensive, and each individual photodermatosis is understood to a different extent. Regardless, there exists a paucity of information with regards to the clinical presentation among those with skin of colour. With ever-changing global demographics, recognition of photosensitive disorders in a diverse population is essential for accurate diagnoses and therapeutic guidance. The scope of this article seeks to review the epidemiology and clinical variability in presentation of such photodermatoses in patients with skin of colour.

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Comparison of patch test results with a standard series among white and black racial groups

Abstract: The differences in sensitization rates, especially for p-phenylenediamine, may reflect variations in allergen exposure among racial groups or interindividual variations in the N-acetylation (N-acetyltransferase 1 [NAT1] and 2 [NAT2]) capacities of human skin for p-phenylenediamine.

Cited by 28 publications

References 31 publications

The prevalence of allergic contact sensitization in a general population in Tromso, Norway

The prevalence of allergic contact sensitization in a general population in Tromso, Norway

Acetylator phenotype in Iraqi patients with allergic contact dermatitis

Photodermatoses in skin of colour

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