Comparison of parameters of 123I-MIBG scintigraphy for predicting prognosis in patients with dilated cardiomyopathy

Momose, Mitsuru; Kobayashi, Hideki; Iguchi, Nobuo; Matsuda, Naoki; Sakomura, Yasunari; Kasanuki, Hiroshi; Kusakabe, Kiyoko; Okawa, Toru

doi:10.1097/00006231-199906000-00007

Cited by 61 publications

(37 citation statements)

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“…21,32 This discrepancy may be caused by differences in the treatment period or the small number of patients in the present study. Cohen-Solal et al reported that there was no significant difference in H/M ratio between survivors and nonsurvivors or cardiac transplantation recipients, 22 which concurs with our results, so multicenter research involving larger numbers of patients is needed to clarify the significance of the findings.…”

Section: Usefulness Of the Change In The Mibg Parameters After Optimimentioning

confidence: 68%

“…Therefore, the H/M ratio is more useful for predicting the mortality of patients with DCM than the washout rate, which is consistent with the results of previous studies, 21,22 although there have been contradictory reports. 32,33 The washout rate is Receiver operating characteristic (ROC) curves for prediction of mortality. The ROC curves showed a greater area under the curves for the plasma brain natriuretic peptide (BNP) at 6 months and the changes in the heart to mediastinum (H/M) ratio than for the curve of the H/M ratio before, confirming a significantly better prognostic value of BNP and the H/M ratio in predicting mortality and morbidity.…”

Section: Usefulness Of the Change In The Mibg Parameters After Optimimentioning

confidence: 99%

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Prognostic Value of Repeated 123I-Metaiodobenzylguanidine Imaging in Patients With Dilated Cardiomyopathy With Congestive Heart Failure Before and After Optimized Treatments-Comparison With Neurohumoral Factors.

Matsui

Tsutamoto

Maeda

et al. 2002

Circ J

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Section: Usefulness Of the Change In The Mibg Parameters After Optimimentioning

confidence: 68%

Section: Usefulness Of the Change In The Mibg Parameters After Optimimentioning

confidence: 99%

Prognostic Value of Repeated 123I-Metaiodobenzylguanidine Imaging in Patients With Dilated Cardiomyopathy With Congestive Heart Failure Before and After Optimized Treatments-Comparison With Neurohumoral Factors.

Matsui

Tsutamoto

Maeda

et al. 2002

Circ J

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“…In many studies, it has been reported that impaired cardiac adrenergic innervation as assessed by 123 I-MIBG imaging was closely associated with mortality in patients with HF (35)(36)(37). Some studies demonstrated that 123 I-MIBG imaging was a good predictor of response to adrenergic b-blocker therapy (38,39).…”

Section: Discussionmentioning

confidence: 99%

Decreased Myocardial -Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy

Tsukamoto¹,

Morita²,

Naya³

et al. 2007

Journal of Nuclear Medicine

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Cardiac sympathetic function plays an important role in the regulation of left ventricular (LV) function and the pathophysiology of LV dysfunction. 11 C-CGP-12177 ( 11 C-CGP) has been used to assess myocardial b-adrenergic receptor (b-AR) density in vivo using PET. The aim of this study is to measure myocardial b-AR density in patients with nonischemic cardiomyopathy and to compare the measurements with various standard parameters of heart failure (HF), particularly with presynaptic function assessed by 123 I-metaiodobenzylguanidine ( 123 I-MIBG) imaging. Methods: 11 C-CGP PET was performed on 16 patients with nonischemic cardiomyopathy and 8 age-matched healthy volunteers using a double injection method. A 11 C-CGP dynamic scan for 75 min was performed after the injection of 11 C-CGP with a high specific activity. After 30 min, 11 C-CGP with a low specific activity was injected. The b-AR density of the whole LV was calculated on the basis of the graphical analysis method. Additionally, b-AR density was compared with LV ejection fraction (LVEF), sympathetic presynaptic function assessed using 123 I-MIBG kinetics, and neurohormonal parameters. Results: The b-AR density of patients was significantly lower than that of healthy volunteers (3.80 6 0.96 vs. 7.70 6 1.92 pmol/mL; P , 0.0001). In the patients, b-AR density correlated significantly with LVEF (r 5 0.62, P , 0.05). Furthermore, b-AR density correlated significantly with the 123 I-MIBG washout rate (r 5 20.68, P , 0.01) and delayed heart-to-mediastinum ratio (H/M ratio) (r 5 0.61, P , 0.05). On the other hand, the correlation between b-AR density and early H/M ratio was not significant (r 5 0.40, P 5 0.13). The b-AR density of patients with severe HF (New York Heart Association functional [NYHA] class III) was significantly lower than that of those with NYHA functional class I or class II HF (3.24 6 0.96 vs. 4.24 6 0.73 pmol/mL; P , 0.05). Conclusion: A reduction in b-AR density measured by 11 C-CGP PET was observed in patients with nonischemic cardiomyopathy. This downregulation may be due to the increased presynaptic sympathetic tone as assessed by 123 I-MIBG imaging.

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“…In a heterogeneous population of patients with heart failure, the most important determinant of cardiac uptake of 123 I-MIBG is the degree of impairment of the norepinephrine transporter function in presynaptic adrenergic neurons [2][3][4][5][6][7][8][9][10]. As such, considerable variation in late H/M ratio would be expected between patients with otherwise similar clinical presentations (NYHA class, LVEF, etc).…”

Section: Acquisition Parametersmentioning

confidence: 99%

“…In the past two decades, a large number of investigators have demonstrated decreased myocardial 123 I-MIBG uptake in patients with chronic heart failure (CHF) and have shown that those with the lowest uptake tend to have the poorest prognosis [2][3][4][5][6][7][8][9][10][11][12]. There have also been findings suggesting that abnormalities of myocardial 123 I-MIBG uptake may be predictive of increased risk of ventricular arrhythmia and sudden cardiac death [13,14].…”

Section: Introductionmentioning

confidence: 99%

How to use myocardial 123I-MIBG scintigraphy in chronic heart failure

Denis

Carrió

Verberne

2008

Eur J Nucl Med Mol Imaging

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Comparison of parameters of 123I-MIBG scintigraphy for predicting prognosis in patients with dilated cardiomyopathy

Cited by 61 publications

References 0 publications

Prognostic Value of Repeated 123I-Metaiodobenzylguanidine Imaging in Patients With Dilated Cardiomyopathy With Congestive Heart Failure Before and After Optimized Treatments-Comparison With Neurohumoral Factors.

Prognostic Value of Repeated 123I-Metaiodobenzylguanidine Imaging in Patients With Dilated Cardiomyopathy With Congestive Heart Failure Before and After Optimized Treatments-Comparison With Neurohumoral Factors.

Decreased Myocardial -Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy

How to use myocardial 123I-MIBG scintigraphy in chronic heart failure

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