How to use myocardial 123I-MIBG scintigraphy in chronic heart failure

Denis, Arnaud; Carrió, Ignasi; Verberne, Hein J.

doi:10.1007/s00259-008-0976-x

Cited by 87 publications

(68 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The standard procedure used in a 115 It is accepted that standard HF medications such as ß-blockers, angiotensin-converting enzyme inhibitors (ACE-I), and/or angiotensin receptor blockers (ARBs) need not be held. [116][117][118][119] However, it is recommended to temporarily discontinue medications and substances known to interfere directly with the mechanisms of NE uptake and granule storage, such as opioids, cocaine, tramadol, tricyclic antidepressants sypathomimetrics, some antihypertensive and cardiovascular agents, and antipsychotics (see detail in Table 7). 118 In addition, foods containing vanillin and catecholamine-like compounds (e.g., chocolate and blue cheese) should be stopped.…”

Section: Tracer Administrationmentioning

confidence: 99%

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Henzlova

Duvall

Einstein

et al. 2016

Journal of Nuclear Cardiology

Self Cite

516

386

View full text Add to dashboard Cite

Section: Tracer Administrationmentioning

confidence: 99%

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Henzlova

Duvall

Einstein

et al. 2016

Journal of Nuclear Cardiology

Self Cite

516

386

View full text Add to dashboard Cite

“…It is possible that the H/M r (e) matches the information on the density of postsynaptic adrenergic receptors and integrity of the presynaptic terminal (sympathetic neurons). But the value of H/M r (d) refers to the pre-synaptic neuron function that includes release, capture and storage of adrenaline 23 . The late rate decreasing more than the early one, seems to be related to the initial phase of the cardiac sympathetic alteration caused by the PD, in which, during the progression of neuronal pathological process, the dysfunction would precede the estrutural destruction for a while 24 .…”

Section: Discussionmentioning

confidence: 99%

Cardiac 123I-MIBG uptake in de novo Brazilian patients with Parkinson's disease without clinically defined dysautonomia

Leite

Nascimento

Pereira

et al. 2014

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Myocardial scintigraphy with meta-iodo-benzyl-guanidine (123I cMIBG) has been studied in Parkinson's disease (PD), especially in Asian countries, but not in Latin America. Most of these studies include individuals with PD associated to a defined dysautonomia. Our goal is to report the cardiac sympathetic neurotransmission in de novo Brazilian patients with sporadic PD, without clinically defined dysautonomia. We evaluated retrospectively a series of 21 consecutive cases with PD without symptoms or signs of dysautonomia assessed by the standard bedside tests. This number was reduced to 14 with the application of exclusion criteria. 123I cMIBG SPECT up-take was low or absent in all of them and the heart/mediastinum ratio was low in 12 of 14. We concluded that 123I cMIBG has been able to identify cardiac sympathetic neurotransmission disorder in Brazilian de novo PD patients without clinically defined dysautonomia.

show abstract

“…The late H/M ratio combines information on neuronal function from uptake to release through the storage vesicles at the nerve terminals [6].…”

Section: Technical Considerations For Cardiac Mibg Imagingmentioning

confidence: 99%

Neurological applications for myocardial MIBG scintigraphy

Cacace²,

Antonio³

et al. 2013

Nucl. Med. Rev.

View full text Add to dashboard Cite

Signs or symptoms of impaired autonomic regulation of circulation are typically present in patients affected by Parkinson's disease (PD), in agreement with the cardiac sympathetic denervation discovered by Goldstein more than 15 yrs. ago.In particular, the majority of PD patients have a diffuse left ventricular myocardial sympathetic denervation, being a normal neurological condition present only in a small number of affected subjects. Actually MIBG cardiac imaging is a universally accepted method to estimate cardiac sympathetic innervations. This review covers the role of MIBG cardiac imaging in PD as well as in other parkinsonisms, focusing the attention on technical problems and pathophysiological premises for cardiac denervation. In particular new emerging data support the role of MIBG as biomarker of PD, also before motor symptoms became clinically evident. Therefore the timing of cardiac noradrenergic denervation in PD is a key issue and we want to update the analysis of autonomic cardiovascular abnormalities studied with MIBG in PD and related disorders.

show abstract

How to use myocardial 123I-MIBG scintigraphy in chronic heart failure

Cited by 87 publications

References 18 publications

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Cardiac 123I-MIBG uptake in de novo Brazilian patients with Parkinson's disease without clinically defined dysautonomia

Neurological applications for myocardial MIBG scintigraphy

Contact Info

Product

Resources

About