Comparison of oxidative stress between premenopausal and postmenopausal women

Vincent, Josephine; Inassi, Jiji

doi:10.5455/njppp.2020.10.02051202002032020

Cited by 3 publications

(1 citation statement)

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“…Diet, antioxidant supplements, and moderate physical activity can prevent menopause-related disorders. 36 Menopause is also associated with the inflammatory process so that the levels of proinflammatory cytokines such as hc1β, IL-8, and TNF-α are higher and the serum IL-20 levels are lower in postmenopausal women compared to fertile women; in addition, their serum IL-8 levels are similar to those of the patients with chronic inflammatory diseases. 37 Vitamin E is a powerful antioxidant that inhibits the production of reactive oxygen species caused by lipid oxidation and during the release of free radicals.…”

Section: Main Findingmentioning

confidence: 99%

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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This systematic review was conducted to investigate the effects of vitamin E and omega-3 used alone and in combination on the frequency and intensity of hot flushes (primary outcomes) and adverse effects (secondary outcome) in menopausal women. English and Persian databases were searched until March 18, 2021. The quality of the published papers was evaluated using Cochrane Handbook and the meta-analysis was conducted in RevMan 5.3. Heterogeneity was assessed using I2. In cases with substantial heterogeneity, a random effects model was used instead of a fixed effects model. A total of 387 papers were obtained from the databases. Finally, 10 papers with a sample size of 1100 participants entered the systematic review and a meta-analysis was conducted on nine of them. The results of the meta-analysis of two studies indicated that using vitamin E and omega-3 in combination significantly reduced the intensity of hot flushes compared to the placebo (mean difference (MD): −0.35; 95% CI: −0.48 to −0.21). The mean frequency (MD: −0.50; 95% CI: −1.58 to 0.58) and intensity (SMD: −0.61; 95% CI: −1.50 to 0.29) of hot flushes in the omega-3 group and the frequency of hot flushes (SMD: −0.21; 95% CI: −0.47 to 0.04) in the vitamin E group showed no significant differences with the placebo. No serious adverse effects were reported in the studies. Given the low number of RCTs, more clinical trials with larger sample size are required.

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Section: Main Findingmentioning

confidence: 99%

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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The impact of aerobic exercise training and crocin consumption on MuRf-1 level in skeletal muscle in high-fat fed ovariectomized rat models

Kheradmand,

Rajabi,

Talebi-Garakani

2023

Comp Clin Pathol

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Comparison of Serum Iron, Zinc, and Selenium Levels in Premenopausal and Postmenopausal Women in Ekpoma, Nigeria: A Descriptive Study

Festus

Agbebaku

Idonije

et al. 2020

Avicenna J Med Biochem

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Background: Estrogen deficiency following menopause creates an imbalance in plasma micronutrient resulting in several degenerative pathological conditions, including hypertension, cardiovascular disease, osteoporosis, etc. Objectives: The present study was designed to compare zinc (Zn), iron (Fe), and selenium (Se) concentrations between premenopausal and postmenopausal women. Methods: In this descriptive study a total of 200 participants were classified into two groups of postmenopausal (age range: 46-75 years, served as experimental) and premenopausal (age range: 30-45 years, served as control). Each group consisted of 100 subjects. After obtaining informed consent from all participants, blood samples were collected from the antecubital fossa vein of each participant by venipuncture. The concentrations of Fe, Zn, and Se in each blood sample were determined using Atomic Absorption Spectrophotometer. Results: No significant difference (P>0.05) was observed in serum Fe (114.24 ± 26.79 µg/dL), Zn (83.11 ± 20.45 µg/dL), and Se (41.99 ± 9.78 µg/dL) levels between the control and experimental groups. However, serum Fe and Zn showed progressive significant (P=0.04, 0.03, respectively) increase with increasing postmenopausal age. Conversely, serum Se concentration decreased significantly (P=0.03) with increasing menopausal age. Conclusion: Although no significant difference was observed in serum levels of Fe, Zn, and Se between pre- and post-menopausal women, the progressive significant increase in the serum Fe and Zn levels as well as significant decrease in serum Se level with advancing post-menopausal age portend a great risk.

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Comparison of oxidative stress between premenopausal and postmenopausal women

Cited by 3 publications

References 0 publications

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

The impact of aerobic exercise training and crocin consumption on MuRf-1 level in skeletal muscle in high-fat fed ovariectomized rat models

Comparison of Serum Iron, Zinc, and Selenium Levels in Premenopausal and Postmenopausal Women in Ekpoma, Nigeria: A Descriptive Study

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