Comparison of outpatient visits and hospitalisations, in patients with chronic obstructive pulmonary disease, before and after influenza vaccination

Menon, Balakrishnan; Gurnani, M.; Aggarwal, Bhumika

doi:10.1111/j.1742-1241.2007.01641.x

Cited by 26 publications

(21 citation statements)

References 32 publications

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“…[22–25] However, despite clear guidelines for routine influenza vaccination in patients with COPD, vaccination rates in the U.S. continue to be below the target rates of both the World Health Organization and the U.S. Public Health Service “Healthy People 2010” initiative for all age and risk groups. [26] Our results indicate that there is still a significant burden of COPD hospitalizations related to influenza.…”

Section: Discussionmentioning

confidence: 99%

Predicting Chronic Obstructive Pulmonary Disease Hospitalizations Based on Concurrent Influenza Activity

Gerke¹,

Tang²,

Yang³

et al. 2013

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Although influenza has been associated with chronic obstructive pulmonary disease (COPD) exacerbations, it is not clear the extent to which this association affects healthcare use in the United States. The first goal of this project was to determine to what extent the incidence of COPD hospitalizations is associated with seasonal influenza. Second, as a natural experiment, we used influenza activity to help predict COPD admissions during the 2009 H1N1 influenza pandemic. To do this, we identified all hospitalizations between 1998 and 2010 in the Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project (HCUP) during which a primary diagnosis of COPD was recorded. Separately, we identified all hospitalizations during which a diagnosis of influenza was recorded. We formulated time series regression models to investigate the association of monthly COPD admissions with influenza incidence. Finally, we applied these models, fit using 1998–2008 data, to forecast monthly COPD admissions during the 2009 pandemic. Based on time series regression models, a strong, significant association exists between concurrent influenza activity and incidence of COPD hospitalizations (p-value<0.0001). The association is especially strong among older patients requiring mechanical ventilation. Use of influenza data to predict COPD admissions during the 2009 H1N1 pandemic reduced the mean-squared prediction error by 29.9%. We conclude that influenza activity is significantly associated with COPD hospitalizations in the United States and influenza activity can be exploited to more accurately forecast COPD admissions. Our results suggest that improvements in influenza surveillance, prevention, and treatment may decrease hospitalizations of patients diagnosed with COPD.

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Section: Discussionmentioning

confidence: 99%

Predicting Chronic Obstructive Pulmonary Disease Hospitalizations Based on Concurrent Influenza Activity

Gerke¹,

Tang²,

Yang³

et al. 2013

COPD: Journal of Chronic Obstructive Pulmonary Disease

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show abstract

“…In a before-and-after study the benefits of influenza vaccination among 87 people with COPD on prevention of acute respiratory illness and acute exacerbations from COPD was evaluated [58]. The authors found that the incidence of acute respiratory illness and acute exacerbation from COPD significantly decreased after vaccination (reduced from 28.6 per 100 person-years prior to vaccination to 9.7 per 100 person-years postvaccination: RR=0.33, p=0.005).…”

Section: Effectiveness Of the Influenza Vaccinementioning

confidence: 97%

Understanding 30‐day re‐admission after hospitalisation of older patients for diabetes: identifying those at greatest risk

Caughey

Pratt

Barratt

et al. 2017

Medical Journal of Australia

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“…Infl uenza vaccination reduces overall mortality by 70% in patients with chronic lung disease (odds ratio 0.30, p Ͻ 0.001) (Nichol et al 1999a). However, it does not appear to modify the rate of exacerbations in patients with mild COPD (Menon et al 2008;Poole et al 2006). Pneumococcal vaccination is also associated with reduced risk of hospitalizations from pneumonia as well as all-cause mortality beyond that achieved with infl uenza vaccination (Nichol et al 1999b).…”

Section: Vaccinationmentioning

confidence: 95%

Treatment of mild chronic obstructive pulmonary disease

Chee

Sin

2008

COPD

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Chronic obstructive pulmonary disease (COPD) is an epidemic in many parts of the world. Most patients with COPD demonstrate mild disease. The cornerstone of management of mild disease is smoking cessation, which is the only proven intervention to relieve symptoms, modify its natural history and reduce mortality. For asymptomatic patients, it is the only required therapy. Short-acting bronchodilators can be added on an as needed basis for those with intermittent symptoms and regularly for those with persistent symptoms. Long-acting bronchodilators can be substituted for those who remain symptomatic despite regular use of short-acting bronchodilators. Inhaled corticosteroids do not modify the natural history of COPD and as such cannot be recommended as standalone therapy for mild COPD. However, for patients with refractory and intractable symptoms, they may be used in combination with long-acting beta-2 agonists. Infl uenza and pneumococcal vaccination and pulmonary rehabilitation are other therapies that may be considered for select patients with mild disease. In this paper, we summarize the current standard of care for patients with mild COPD.

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Comparison of outpatient visits and hospitalisations, in patients with chronic obstructive pulmonary disease, before and after influenza vaccination

Abstract: Influenza vaccination is highly effective in the prevention of ARI. Maximum protection was found to be in patients with severe COPD. Influenza vaccination in patients is associated with fewer outpatient visits and fewer hospitalisations.

Cited by 26 publications

References 32 publications

Predicting Chronic Obstructive Pulmonary Disease Hospitalizations Based on Concurrent Influenza Activity

Predicting Chronic Obstructive Pulmonary Disease Hospitalizations Based on Concurrent Influenza Activity

Understanding 30‐day re‐admission after hospitalisation of older patients for diabetes: identifying those at greatest risk

Treatment of mild chronic obstructive pulmonary disease

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