Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet’s Disease and Healthy Controls

Koca, Semra; Onan, Duru; Kalayci, Defne; Allı, Nuran

doi:10.1080/09273948.2019.1635167

Cited by 20 publications

(23 citation statements)

References 19 publications

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“…13,17 For the comparison of FAZ area between NOBD patients and HVs, other studies have reported inconsistent results. Similar to our results, Goker et al 19 found FAZ enlargement, whereas three other studies 8,18,20 did not find a significant difference in FAZ area between NOBD patients and HVs. These inconsistent reports on FAZ area differences between NOBD eyes and healthy eyes could be explained by the high between-subject variability of FAZ area measurements in healthy eyes.…”

Section: Discussionsupporting

confidence: 91%

“…The vessel density was significantly lower in the BU group than in the control group in all three retinal layers, which is in line with results of vessel density or hypoperfusion area measurements in previous studies. 6,13,15,17,18 The VD of NOBD patients was significantly different from both the vessel density in BU patients in all three layers and from the VD in healthy control subjects in the deeper retinal layers (DCP and ICP). This suggests that the deeper layers of the retina in NOBD patients deviate more from a normal microcirculation than does the SVP.…”

Section: Discussionmentioning

confidence: 93%

“…Some studies have investigated VD and FAZ area changes in NOBD patients, but have shown inconsistent results. 8,[18][19][20] VD was reduced in NOBD patients compared to healthy control subjects in three out of the four studies, 8,19,20 and FAZ area was larger in the NOBD than in healthy controls in only one of the four studies. 19 Given the limited number of studies and their inconsistent results mainly due to small sample sizes, further exploration of preclinical retinal microvascular changes in NOBD patients compared to BU patients in a large group and a comparison to healthy volunteers (HVs) is warranted.…”

mentioning

confidence: 78%

“…However, it is more logical to analyze the FAZ area including all retinal vascular plexuses together, as the three retinal vascular layers merge at the edge of the FAZ and therefore define the borders of the FAZ together. 23,31 Another bias can be found in the FAZ data reported by Koca et al, 18 who included 94 eyes from 49 Behҫet's disease patients, of which 43 eyes had ocular involvement, and one eye of 53 healthy controls. The fellow eyes of uveitic patients were included in their NOBD group.…”

Section: Discussionmentioning

confidence: 99%

“…6,16,17 Furthermore, it is suggested that FAZ irregularity could be a marker of ocular involvement of Behҫet's disease. 18 Because FAZ irregularity has only been assessed subjectively, further exploration for quantitative measurement of FAZ irregularity is warranted.…”

mentioning

confidence: 99%

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Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

Smid

Vermeer

Missotten

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To compare quantitative optical coherence tomography angiography (OCT-A) measurements of the parafoveal microvasculature in retinal capillary plexuses among Behҫet uveitis (BU) patients, non-ocular Behҫet's disease (NOBD) patients, and healthy volunteers (HVs). METHODS. Sixty-eight subjects were enrolled in this prospective observational crosssectional study. OCT-A imaging was performed using the Heidelberg Engineering Spectralis OCT. A custom algorithm was developed to calculate the vessel density (VD) in three retinal vascular layers: deep capillary plexus, intermediate capillary plexus, and superficial vascular plexus. The foveal avascular zone (FAZ) and acircularity index were calculated for the whole retinal vascular complex. RESULTS. We analyzed one eye from 21 BU patients (age, 51 ± 10 years), 23 NOBD patients (age, 48 ± 14 years), and 22 HVs (age, 44 ± 13 years). One-way multivariate analysis of covariance showed a statistically significant difference in VD among the three groups when combining the layers after controlling for scan quality (P < 0.001). The VD was lowest in the BU group and highest in the HV group in all layers. The FAZ area was also statistically significant different among the groups (P < 0.005), with the largest FAZ areas in BU patients and smallest FAZ areas in the HV group. However, no statistically significant difference was found for the acircularity index. CONCLUSIONS. The parafoveal microvasculature is affected not only in BU patients but also in NOBD patients. Most deviations in the retinal microcirculation in Behҫet patients were found in the deeper layers of the retina by using the quantitative VD measurement.

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