Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma

Takeyama, Asuka; Ishida, Kyoko; Anraku, Ayako; Ishida, Masahiro; Tomita, Goji

doi:10.1155/2018/1751857

Cited by 19 publications

(15 citation statements)

References 38 publications

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“…A consequence of the nonmonotonic relation between severity and blood flow is that the parameter MBR ave is unlikely to be useful for the diagnostic detection of disease since a value within normal limits would reappear after considerable loss of axons. This may explain why vessel density measured using OCTA has been reported as having better discriminatory power between eyes with glaucoma versus controls than do LSFG parameters 58. Other LSFG parameters may prove more useful for discrimination than MBR ave .…”

Section: Discussionmentioning

confidence: 99%

Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma

Gardiner

Cull

Fortune

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Blood flow in the optic nerve head (ONH) is known to be reduced in eyes with advanced glaucoma. However, experimental results from non-human primates suggest an initial increase in ONH blood flow at the earliest stages of damage. This study assesses flow and pulsatile hemodynamics across a range of severities to test the hypothesis that this also occurs in human glaucoma. METHODS. Laser speckle flowgraphy was used to measure average mean blur rate (MBR ave) within ONH tissue (a correlate of capillary blood flow) and the pulsatile waveform in 93 eyes with functional loss and 74 glaucoma suspect/fellow eyes without functional loss. These were compared against results from 92 healthy control eyes. Parameters produced by the instrument's software were age-corrected, then compared between groups using generalized estimating equation models. RESULTS. The mean MBR ave in the control eyes was 12.5 units. In glaucoma suspect/fellow eyes, the mean was 16.4 units, higher with P < 0.0001. In eyes with functional loss, the mean was 13.8 units, lower than eyes without functional loss with P < 0.0001, although still higher than control eyes with P ¼ 0.0096. Analysis of the pulsatile waveform suggested that the deceleration in flow as it approaches its maximum across the cardiac cycle was delayed in glaucoma. CONCLUSIONS. Blood flow within ONH capillaries was higher in glaucoma suspect eyes than in healthy controls. It was less elevated in eyes that had developed functional loss. The mechanisms causing these changes and their relation to concurrent changes in pulsatile hemodynamics remain under investigation.

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Section: Discussionmentioning

confidence: 99%

Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma

Gardiner

Cull

Fortune

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Within the perimetrically undamaged area, RNFL was significantly lower in the superior nasal and upper nasal sectors (P=0.02) but VD showed no changes 11 . For NTG, a change in vascular density in the peripapillary region was registered [12][13][14][15][16][17] .…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Žáková

Lešták

Fus

et al. 2021

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion nerve fibres (RNFL). In normotensive glaucoma (NTG), the retinal ganglion cells are relatively intact. The pathology is at the level of ganglion fibres. The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG? Aim. The aim of this study was to determine whether there is a correlation between the retinal nerve fibre layer (RNFL) and vessel density (VD) at the same altitudinal half of the retina and the sum of sensitivities of the contralateral half of the visual field of the same eye in hypertensive and normotensive glaucoma (NTG). Methods. Our group included 20 patients with HTG and 20 patients with NTG. The Pearson's correlation coefficient r was used for evaluation of the relationship of the peripapillary RNFL and VD, visual field (using the fast threshold glaucoma program) as the sum of sensitivities in apostilbs (asb) to the extent of 0-22 degrees. The results of sensitivity were compared with the RNFL and VD of the contralateral altitudinal half of the retina in the same eye. Results. In the HTG group there was a moderate relationship between RNFL and VD (both hemifields), but no relationship between RNFL and VF. VD SH and VF IH showed weak correlation and VD IH and VF SH showed no correlation. In patients with NTG, we found a strong correlation between RNFL and VD (both hemifields), between VD SH and VF IH a moderate correlation, between VD IH and VF SH also a moderate correlation and a weak correlation between RNFL and VF. Conclusion. By comparing the RNFL and VD at the same altitudinal halves of the retina, we found a moderate correlation in HTG and a strong correlation in NTG. We found no or a weak correlation between VD and VF in HTG. In NTG the relationship between VD and VF showed a strong correlation. These findings reveal the differences in the diagnostic groups.

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“…Recently, in a comparison of MBR obtained by LSFG with the peripapillary relative intensity (PRI) acquired by OCTA, superficial-choroidal PRI was found significantly correlated with MBR in the ONH tissue area 21. Another study found OCTA vessel density had a higher glaucoma diagnostic ability compared to LSFG parameters in patients with normal tension glaucoma (NTG) 22. Thus, LSFG and OCTA are both useful tools for managing glaucoma, and it is considered to be meaningful to investigate the relationship between the two more deeply.…”

Section: Introductionmentioning

confidence: 99%

<p>Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes</p>

Kohmoto¹,

Sugiyama²,

Ueki³

et al. 2019

OPTH

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PurposeTo investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of the peripapillary retina and optic nerve head (ONH) in normal eyes and eyes with primary open-angle glaucoma (POAG).Patients and methodsOne eye from each of 46 normal subjects and mild and moderate/advanced POAG patients were included. ONH blood flow acquired by LSFG, circumpapillary vessel density (cpVD, a 250 μm-wide elliptical annulus around the optic disc), and intra-papillary vessel density (ipVD, a 1.5×1.5 mm scan field) acquired by OCTA were measured. Their values were compared among normal controls and patients at each stage of glaucoma using one-way ANOVA, and the correlation between measurements obtained by the two methods was examined by univariate regression analysis.ResultsONH tissue blood flow, tissue mean blur rate (MBR-T), and cpVD in the outer layer of the retina significantly decreased with the progression of glaucoma stage, although the latter showed no significant difference between normal subjects and mild-stage glaucoma patients. MBR-T was significantly correlated with cpVD, but not with ipVD, in the retinal outer layer.ConclusionA correlation was found only between MBR-T and cpVD in the retinal outer layer. A difference in MBR-T, but not in cpVD, was detected between normal controls and mild glaucoma patients.

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Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma

Cited by 19 publications

References 38 publications

Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma

Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

<p>Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes</p>

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