&lt;p&gt;Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes&lt;/p&gt;

Kohmoto, Ryohsuke; Sugiyama, Tetsuya; Ueki, Mari; Kojima, Shota; Maeda, Michiaki; Nemoto, Emika; Tokuoka, Satoru; Ikeda, Tsunehiko

doi:10.2147/opth.s213031

Cited by 8 publications

(14 citation statements)

References 31 publications

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“…Retinal and choroidal blood flow can be altered in several retinal and systemic vascular diseases 1 , 2 , 3 , 4 , 5 . Approaches assessing blood flow within these patients help to understand the pathophysiology, monitor the diseasesʼ dynamics, and adapt therapeutic procedures accordingly 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

“…The retina offers the possibility to measure blood flow within the human body in a noninvasive manner. Compared to optical coherence tomography angiography (OCTA), which only offers structural images, and fluorescein angiography (FA), which is invasive and time-consuming, laser speckle flowgraphy (LSFG) offers a noninvasive and fast way to image patients and quantify their blood flow 1 , 2 , 3 , 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy

Bajka

Foa

Sidhu

et al. 2023

Klin Monbl Augenheilkd

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Purpose To assess optic nerve head (ONH) and macular blood flow in young healthy volunteers using laser speckle flowgraphy (LSFG). Methods This is a prospective single-center study conducted at the Department of Ophthalmology, University Hospital Zurich from May to November 2021. Young, healthy men aged ≥ 18 years without ocular or systemic diseases were included. A corrected visual acuity (VA) of 0.0 logMAR or better in both eyes and an intraocular pressure (IOP) of 21 mmHg or lower were required for inclusion. Subjects exceeding a spherical equivalent (SE) of ± 6 diopters (dpt) were excluded. Blood flow in the macula and the ONH was recorded using the Nidek LSFG RetFlow device (Nidek Company, Ltd., Hirioshi-cho, Japan). Laser power was set to 0.5 Millivolts (mV). Mean blur rate (MBR) was recorded as a parameter for blood flow. MBR is a calculated parameter that represents relative blood flow velocity correlated with the real anatomical blood flow rate. Colored heat maps of the recorded retinal area were generated automatically by the RetFlow device. Results Final analyses included 83 eyes of 43 male volunteers. Mean age was 21.9 years (SD ± 1.5, range: 20 to 29). Mean corrected VA was − 0.1 logMAR (SD ± 0.05, range: − 0.2 to 0.0), mean IOP was 15.4 mmHg (SD ± 2.5, range: 8.5 to 18.5), and mean SE was − 0.3 dpt (SD ± 1.2, range: − 5.0 to 1.2). Mean ONH MBR was 37.44 (SD ± 7.9, range: 22.5 to 53.5) and mean macular MBR was 27.8 (SD ± 9.7, range: 6.4 to 57.7). Pearsonʼs Test showed a strong correlation between macular and papillary blood flow (p < 0.05, coefficient: 0.647). Conclusion This study provides both ONH and macular blood flow data in a healthy young male population, showing a strong correlation between ONH and macular blood flow in the examined eyes. Further investigations are required to assess the validity of MBR as a parameter for the combined evaluation of retinal blood flow at the macula and ONH in healthy volunteers and patients with various diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy

Bajka

Foa

Sidhu

et al. 2023

Klin Monbl Augenheilkd

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“…The background area in this study has a similar concept to the “tissue area” in some other LSFG studies, but with the emphasis that retinal capillaries and choroidal vessels are also presented in these regions. 33 – 35 Retinal capillaries can contribute to the background LSFG signals in certain ways, although they are barely resolved. In principle, the blood flows in the capillaries can decorrelate the speckles, although at a much lower level compared with those in the arteries or veins.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Laser Speckle Flowgraphy and OCT-Derived Retinal and Choroidal Metrics in Healthy Human Eye

Zhou

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To investigate the correlation between laser speckle flowgraphy (LSFG) signals and the quantitative metrics derived from optical coherence tomography (OCT) in normal eyes. Methods LSFG, OCT, and OCT angiography (OCTA) imaging were performed on normal participants using a custom-designed LSFG system and a commercial swept-source OCT system. Mean (PWM) and amplitude (PWA) of the LSFG pulse waveform were selected to quantify the LSFG signals. Retinal and choroidal maps were obtained using the standard 6 × 6 mm OCT and OCTA scans. Structural and vascular metrics maps, including thickness, vessel area density, vessel skeleton density, and vessel diameter index of the retina, and choroidal thickness (CT), choroidal vessel volume (CVV) and choroidal vessel index (CVI), were employed to quantify the retinal and choroidal properties. Correlation analysis was then performed between the LSFG, retinal, and choroidal metrics maps. Results Twelve healthy participants aged 23 to 36 years were enrolled in this study. The spatial distribution of the PWM and PWA values was highly correlated with that of the CT and CVV metrics. On average, Spearman correlation coefficients (ρ) were 0.80 and 0.78 (all P < 0.001) for the correlations between PWM and CT and CVV, respectively, and were 0.61 and 0.63 (all P < 0.05) for the correlations between PWA and CT and CVV, respectively. In comparison, both PWM and PWA were generally weak or not correlated with all the retinal metrics and CVI. Conclusions LSFG signals were positively correlated with the choroidal thickness and vessel volume, suggesting choroidal blood flows dominate the LSFG signals at the area absent of large retinal vessels. Translational Relevance This study illustrates the dominant source of the LSFG signals in the eye.

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“…[ 10 11 ] Laser speckle flowgraphy (LSFG) has also been used to measure intraocular perfusion. [ 12 13 14 ] This is a novel device that measures sequential perfusion changes, taking the IOP and blood pressure into account, which is suitable for monitoring the tissue circulation at the same site in the same eye at various intervals. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

Change of intraocular blood flow during treatment for thyroid eye disease

Mimura

Nishikawa

Inagaki

et al. 2022

Taiwan J Ophthalmol

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To report a sequential observational study of changes in the retinal and choroidal blood flow during medical and surgical treatments for a thyroid eye disease (TED) patient, using optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG). A 28-year-old man with a history of Graves’ disease diagnosed 8 months prior was presented in the active phase of TED. His clinical activity score (CAS) was 6, but without diplopia or visual loss. Intraocular pressure measurement was OD 20 mmHg and OS 24 mmHg. Thyrotropin receptor antibody (TRAb) and thyroid-stimulating antibody levels were 18.8 IU/L and 4347%. Magnetic resonance imaging revealed enlargement of both extraocular muscles and fat compartments in both orbits. The patient underwent IV pulsed steroid therapy (1 g/day, 3 days) followed by an oral prednisone for 1 month. His CAS score decreased to 4. Bilateral orbital fat decompression decreased his final CAS score to 1 in both eyes. Intraocular blood flow was measured using laser speckle flowgraphy (LSFG), and OCTA was performed. Retinal blood flow increased slightly, but choroidal blood flow showed a robust increase. Choroidal blood flow measured using both LSFG and OCTA was negatively correlated with the CAS score and TRAb. In our case report, the ocular perfusion, especially choroidal blood flow, may decrease in active TED, which may be reversed by medical and surgical treatment.

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<p>Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes</p>

Cited by 8 publications

References 31 publications

Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy

Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy

Correlation Between Laser Speckle Flowgraphy and OCT-Derived Retinal and Choroidal Metrics in Healthy Human Eye

Change of intraocular blood flow during treatment for thyroid eye disease

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