Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma

Yolcu, Yagiz U.; Zreik, Jad; Wahood, Waseem; Bhatti, Atiq ur Rehman; Bydon, Mohamad; Houdek, Matthew T.; Rose, Peter S.; Mahajan, Anita; Petersen, Ivy A.; Haddock, Michael G.; Ahmed, Safia K.; Laack, Nadia N.; Jethwa, Krishan R.; Jeans, Elizabeth B.; Imai, Reiko; Yamada, Shigeru; Foote, Robert L.

doi:10.1001/jamanetworkopen.2021.41927

Cited by 13 publications

(7 citation statements)

References 32 publications

(60 reference statements)

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“…Yolcu et al compared the oncologic outcomes and treatment-related toxicity of CIRT with those of patients undergoing en bloc resection. They found that CIRT can be applied to patients without surgery or older patients with high-performance status and may also provide benefits for patients with margin-positive resection[36]. These studies shed light on the potential benefits of adjuvant radiotherapy for chordoma patients and emphasize the need for further exploration. Fundamental and Clinical Trial Investigation: A primary focus of fundamental research involves exploring the in vitro gene expression of chordoma.…”

Section: Discussionmentioning

confidence: 99%

Global Cluster Analysis and Network Visualization in Chordoma: A Scientometric Mapping

Zheng,

NIU

et al. 2023

Preprint

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Background: A recent scientific and comprehensive examination of the present status and future directions in chordoma research is a subject worth exploring. This study endeavors to investigate and depict the quantitative and qualitative development, research frontiers, and future trends in chordoma using bibliometric approaches. Methods: A total of 2510 publications from the Science Citation Index Expanded of Web of Science Core Collection were obtained from 1991 to 2021 and selected for bibliometric analysis. Bibliometric and knowledge-map analysis were performed using visualized approaches such as VOS viewer and CiteSpace, along with Origin 8.0 and GraphPad prism 8 tools.Results: The top five countries with the highest number of publications are the United States, China, Japan, Italy, and Germany. The most impactful journal is World Neurosurgery, while the most cited journal is Journal of Neurosurgery. The five most common research fields are neuroscience neurology, surgery, oncology, pathology, and radiology nuclear medicine medical imaging. Harvard University has the highest number of publications among institutions, and Gokaslan, Ziya L. has published the most papers and has the highest total link strength. The article "Chordoma: incidence and survival patterns in the United States, 1973-1995" has the most citations. The co-occurrence analysis includes 744 keywords that were categorized into five clusters: radiotherapy study, basic and clinical trill research, diagnostic study, surgical approach research, and prognostic study. CiteSpace identified 12 clusters of keywords, with clusters 0-5, 7, and 12 being former hotspots, clusters 6 and 11 being mid-period hotspots, and cluster 8 being the current research hotspot. Conclusions: This bibliometric analysis and visualized study of chordoma's global research field in the past 30 years is the first of its kind. The findings may help academic researchers comprehend chordoma's dynamic evolution and research trends.

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Section: Discussionmentioning

confidence: 99%

Global Cluster Analysis and Network Visualization in Chordoma: A Scientometric Mapping

Zheng,

NIU

et al. 2023

Preprint

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“…Since April 2016, carbon ion radiotherapy has been available for unresectable/inoperable BSTS in Japan. Following that, proton beam therapy has also been available since April 2018, and in recent years, clinically favorable results for particle beam therapy (carbon ion and proton beam) with regard to unresectable/inoperable BSTSs have been reported [ 12 , 13 , 14 , 15 , 16 , 17 ], especially for chordomas [ 12 , 18 , 19 , 20 ]. However, the long-term outcome of particle beam therapy for BSTS is unclear; therefore, the standard treatment for BSTS, except for chordoma, is still surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan

Takeshita

Kawamoto

Hara

et al. 2022

Cancers

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This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.

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“…31 Carbon ion therapy, a powerful form of radiotherapy with limited worldwide availability, probably has benefit for marginpositive surgical cases or definitive treatment in older patients. 32 At present, there remains considerable variation between centres in how these tumours are approached with regard to the use of radiotherapy, the surgical approach, and planned surgical margin. 33 The above discussion applies to patients with a primary chordoma of the sacrum.…”

Section: Primary Sacral Tumoursmentioning

confidence: 99%

The management of sacral tumours

Rose

2022

The Bone & Joint Journal

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Tumours of the sacrum are difficult to manage. The sacrum provides the structural connection between the torso and lower half of the body and is subject to both axial and rotational forces. Thus, tumours or their treatment can compromise the stability of the spinopelvic junction. Additionally, nerves responsible for lower limb motor groups as well as bowel, bladder, and sexual function traverse or abut the sacrum. Preservation or sacrifice of these nerves in the treatment of sacral tumours has profound implications on the function and quality of life of the patient. This annotation will discuss current treatment protocols for sacral tumours. Cite this article: Bone Joint J 2022;104-B(12):1284–1291.

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Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma

Cited by 13 publications

References 32 publications

Global Cluster Analysis and Network Visualization in Chordoma: A Scientometric Mapping

Global Cluster Analysis and Network Visualization in Chordoma: A Scientometric Mapping

Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan

The management of sacral tumours

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