Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan

Abstract

This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.

Lumbar functional evaluation of pelvic bone sarcomas after surgical resection and spinal pelvic fixation: A clinical study of 304 cases

“…6 However, the technical challenge of achieving R0 resection is compounded by the complex anatomic relationships with vital organs, major vessels, and nerves in the pelvic region. [6][7][8] The utilization of spinal pelvic fixation (SPF) has been adopted in surgical reconstruction procedures following excision, with the intention of providing stabilization to the lumbosacral region. 9 The adequacy and efficacy of SPF are critical factors that contribute significantly to the overall stability of the spinal column and postoperative lumbar function of patients.…”

“…Surgical excision is the principal therapeutic intervention for pelvic bone sarcomas, with R0 resection representing a potentially curative option capable of significantly enhancing prognosis 6 . However, the technical challenge of achieving R0 resection is compounded by the complex anatomic relationships with vital organs, major vessels, and nerves in the pelvic region 6–8 …”

Hip Transposition Can Provide Early Walking Function After Periacetabular Tumor Resection: A Multicenter Study

“…First, the stability of hip transposition relies on the remaining soft tissue, bone structure of the patient, and local scarring of the soft tissue; thus, stability may differ for each patient, and postoperative recovery may be less predictable [10,11,13]. Second, the median survival rate of patients with malignant pelvic bone tumors is not favorable (generally shorter than a few years) compared with that of extremities, and a large portion of patients often undergo postoperative chemotherapy (for osteosarcoma, Ewing sarcoma, or metastatic tumors), for which performance status is critical [4,18,20,21]. Thus, early recovery of daily activity is an important concern, and detailed data on postoperative functional recovery is essential for surgeons and patients when discussing treatment options and participating in shared decision-making.…”