Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient cerebral ischemic damage

Comparison of neuroprotective effects of extract and fractions fromAgarum clathratumagainst experimentally induced transient cerebral ischemic damage

“…This finding is consistent with previous studies reporting delayed neuronal death in the same animal model (Lee et al, 2012;Park et al, 2012;Yu et al, 2012). We observed neuroprotective effects on the ischemic CA1 region according to the sort of extract and fractions from A. clathratum.…”

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

“…In all studies, cognitive impairment was improved and neurological deficits were reduced, suggesting that both tanshinones and despsides were able, even poorly, to pass the BBB and exert their therapeutical effect. Tanshinones, being lipophilic constituents, are administered orally [20] or intraperitoneally [21][22][23][24][25][26][27]. After 10-20 mg/kg, i. p. injections are effective in reducing infarct size, edema, and cell damage in models of cerebral ischemia.…”

“…TSI showed a better inhibitory potency compared to TSIIA with a preferential bind to a hydrophobic β-sheet groove formed by the C-terminal residues of Isoleucine31, Methionine35, and Valine39 of the Aβ pentamer [45]. Park and coworkers [21] reported that TSI was the best neuroprotective tanshinone in the hippocampal CA1 region, using GFAP and IB4 immunohistochemistry. IB4 immunoreactivities were reduced only in the TSI-treated ischemia group [21].…”

“…Park and coworkers [21] reported that TSI was the best neuroprotective tanshinone in the hippocampal CA1 region, using GFAP and IB4 immunohistochemistry. IB4 immunoreactivities were reduced only in the TSI-treated ischemia group [21]. Kim and coworkers [49] reported that TSI activated ERK-CREB signalling pathways in normal mice and ameliorated memory impairments induced by a GABA A receptor agonist or an NMDA receptor antagonist, accompanied by the inhibition of learningassociated ERK and CREB activation in the mouse hippocampus.…”

Clinical Study of Sulfotanshinone Sodium Injection in Treating Non-Ischemic Retinal Vein Occlusion

“…In Traditional Chinese Medicine (TCM), Danshen is considered to promote blood circulation for removing blood stasis and improve microcirculation, which thus has been widely used to treat cardiovascular diseases for more than 2000 years in China [4]. Over the last decade, interest in the mechanism of its versatile protective effects on neurodegenerative diseases, metabolic abnormalities, and ischemic damages has been growing [5]- [7]. Up till now, few studies have reported on its clinical use in the area of retinal ischemic diseases.…”