Comparison of neurokinin substance P with morphine in effects on food-reinforced operant behavior and feeding

Hasenöhrl, Rüdiger U.; Schwarting, Rainer K.W.; Gerhardt, P.; Privou, Caroline; Huston, Joseph P.

doi:10.1016/0031-9384(94)90115-5

Cited by 16 publications

(8 citation statements)

References 43 publications

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“…Five minutes later, the chick was transferred to the running wheel setup and the preference test began immediately. The time to test post‐injection was chosen based on (Boix, Mattioli, Adams, Huston, & Schwarting, ; Hasenöhrl et al., ; Shaikh, Steinberg, & Siegel, ; Thompson et al., ) .…”

Section: Methodsmentioning

confidence: 99%

“…This mechanistic explanation has received renewed attention wherein the need for further studies to be conducted on non‐teleost species to test how widespread this phenomenon may be across vertebrates is emphasized (Ondrasek, ). Indeed, SP has been documented to have behavioural effects on learning and memory (Hasenöhrl, Schwarting, Gerhardt, Privou, & Huston, ) and responses to novelty (Kalivas, Bush, & Hanson, ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of oxytocin‐family peptides and substance P on locomotor activity and filial preferences in visually naïve chicks

Loveland

Stewart

Vallortígara

2019

Eur J of Neuroscience

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Nonapeptides from the vasopressin/oxytocin family have been implicated in a wide variety of social behaviours across vertebrates. Experimental manipulations that alter nonapeptide levels or receptor function in the brain have provided evidence for understanding how nonapeptides influence responses to social stimuli in adults. While behaviours in adults have been extensively studied, much less in known about roles of nonapeptides in early life and the development of affiliative social behaviours. We examined an experience‐independent preference (social predisposition) that is present at hatching and is characterized by the tendency of visually naïve chicks (Gallus gallus) to prefer to approach a stuffed hen stimulus over a control stimulus in a choice test. Among chicks that show the social predisposition preference, bilateral intracranial mesotocin injections resulted in higher mean hen preference scores compared with saline‐injected controls. Equimolar doses of mesotocin and vasotocin injections had different effects on locomotor activity: vasotocin, but not mesotocin, resulted in hypoactivity. We also tested whether intraperitoneal substance P had an effect on hen preference scores because previous research has proposed that vasotocin effects on social approach are mediated by peripheral release of substance P, but found no significant effect. All together, our data suggest that mesotocin signalling may be important for social predispositions and can potentially enhance the perceived salience of social stimuli soon after hatching. Specifically, mesotocin release and signalling in the brain may regulate the ability to recognize naturalistic stimuli and/or to act on the motivation to approach naturalistic stimuli.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of oxytocin‐family peptides and substance P on locomotor activity and filial preferences in visually naïve chicks

Loveland

Stewart

Vallortígara

2019

Eur J of Neuroscience

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“…The neurokinin systems play diverse roles in physiological processes ranging from pain, cardiovascular function and behaviour (reviewed in (Schank, 2020)). Substance P, one of three neurokinin peptides, has been shown to alter the response to alcohol, cocaine and opiate drugs mainly via the neurokinin-1 receptor (NK1R) but IP infusion of substance P in rats also resulted in an anorexigenic effect, with increased latency to eat in food deprived animals (Cador et al, 1986;Hasenöhrl et al, 1994). Peripheral treatment with substance P induced conditioned place preference (Oitzl et al, 1990), an effect that appeared to be brain region specific (reviewed in (Lénárd et al, 2018)).…”

Section: Substance Pmentioning

confidence: 99%

“…Peripheral treatment with substance P induced conditioned place preference (Oitzl et al, 1990), an effect that appeared to be brain region specific (reviewed in (Lénárd et al, 2018)). It was subsequently shown that peripheral treatment with substance P reduced operant responding and ICV infusion of substance P in fasted rats reduced refeeding (Hasenöhrl et al, 1994;Dib, 1999). By contrast, substance P increased food intake in mice, whilst antagonism of the NK1R in DIO and ob/ob animals reduced food intake and body weight (Karagiannides et al, 2008).…”

Section: Substance Pmentioning

confidence: 99%

Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding

Woodward

Gribble

Reimann

et al. 2021

The Journal of Physiology

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The number of people living with obesity has tripled worldwide since 1975 with serious implications for public health, as having obesity is linked to a significantly higher chance of early death from associated comorbidities (metabolic syndrome, type 2 diabetes and cardiovascular disease). As obesity is a consequence of food intake exceeding the demands of energy expenditure, efforts are made to better understand the homeostatic and hedonic mechanisms governing food intake. Gastrointestinal peptides are secreted from enteroendocrine cells in response to nutrient and energy intake, and modulate food intake either via afferent nerves, including the vagus nerve, or directly within the central nervous system, predominantly gaining access at circumventricular organs. Enteroendocrine hormones modulate homeostatic control centres at hypothalamic nuclei and the dorso-vagal complex. Additional roles of these peptides in modulating hedonic food intake and/or preference via the neural systems of reward are starting to be elucidated, with both peripheral and central peptide sources potentially contributing to central receptor activation. Pharmacological interventions and gastric bypass surgery for the treatment of type 2 diabetes and obesity elevate enteroendocrine hormone levels and also alter food preference. Hence, understanding of the hedonic mechanisms mediated by gut peptide action could advance development of potential therapeutic strategies for the treatment of obesity and its comorbidities. Key points-Enteroendocrine cells produce a range of gut peptides that have key roles in the regulation of appetite and beneficial effects on body weight. -Gut peptides are secreted as feedback to nutrient and energy intake, communicating directly or indirectly with the brain. -These peptides, some of which are also expressed in the CNS, alter food intake and reward via their widely distributed receptors. -Understanding these interactions is one of the challenges for developing effective pharmacotherapies that reduce feeding without producing negative side effects (e.g. nausea).

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“…There is evidence that peripheral peptides can influence the brain directly in that systemically-administered SP induces centrally-mediated effects in rodents [6,27,46]. Although unlikely to pass the blood-brain-barrier under physiological conditions, SP may gain entrance rapidly by a specific transport mechanism [9,18], through the AP or other circumventricular organs (CVO's) in the CNS.…”

Section: Behavioral Effects Of Substance P Relate To Cns Penetrationmentioning

confidence: 99%

Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists

et al. 2008

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Substance P (SP) is thought to play a cardinal role in emesis via the activation of central tachykinin NK 1 receptors during the delayed phase of vomiting produced by chemotherapeutics. Although the existing supportive evidence is significant, due to lack of an appropriate animal model, the evidence is indirect. As yet, no study has confirmed that emesis produced by SP or a selective NK 1 receptor agonist is sensitive to brain penetrating antagonists of either NK 1 , NK 2 , or NK 3 receptors. The goals of this investigation were to demonstrate: 1) whether intraperitoneal (i.p.) administration of either SP, a brain penetrating (GR73632) or non-penetrating (e.g. SarMet -SP) NK 1 receptor agonist, an NK 2 receptor agonist (GR64349), or an NK 3 receptor agonist (Pro 7 -NKB), would induce vomiting and/or scratching in the least shrew (Cryptotis parva) in a dose-dependent manner; and whether these effects are sensitive to the above selective receptor antagonists; 2) whether an exogenous emetic dose of SP (50 mg/kg, i.p.) can penetrate into the shrew brain stem and frontal cortex; 3) whether GR73632 (2.5 mg/kg, i.p.)-induced activation of NK 1 receptors increases Fos-measured neuronal activity in the neurons of both brain stem emetic nuclei and the enteric nervous system of the gut; and 4) whether selective ablation of peripheral NK 1 receptors can affect emesis produced by GR73632. The results clearly demonstrated that while SP produced vomiting only, GR73632 caused both emesis and scratching behavior dose-dependently in shrews, and these effects were sensitive to NK 1 -, but not NK 2 -or NK 3 -receptor antagonists. Neither the selective, non-penetrating NK 1 receptor agonists, nor the selective NK 2 -or NK 3 -receptor agonists, caused a significant dose-dependent behavioral effect. An emetic dose of SP selectively and rapidly penetrated the brain stem but not the frontal cortex. Systemic GR73632 increased Fos expression in the enteric nerve plexi, the medial subnucleus of nucleus tractus solitarius, and the dorsal motor nucleus of the vagus, but not the area postrema. Ablation of peripheral NK 1 receptors attenuated the ability of GR73632 to induce a maximal frequency of emesis and shifted its percent animals vomiting dose-response curve to the right. The NK 1 -ablated shrews exhibited scratching behavior after systemic GR73632-injection. These results, for the first time, affirm a cardinal role for central NK 1 receptors in SP-induced vomiting, and a Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. facilitatory role for gastrointestinal NK 1 receptors. In addition, the...

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Comparison of neurokinin substance P with morphine in effects on food-reinforced operant behavior and feeding

Cited by 16 publications

References 43 publications

Effects of oxytocin‐family peptides and substance P on locomotor activity and filial preferences in visually naïve chicks

Effects of oxytocin‐family peptides and substance P on locomotor activity and filial preferences in visually naïve chicks

Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding

Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists

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