Comparison of Nanoindentation Measurements Between Osteogenesis Imperfecta Type III and Type IV and Between Different Anatomic Locations (Femur/Tibia versus Iliac Crest)

Fan, Zaifeng; Smith, Peter A.; Harris, Gerald F.; Rauch, Frank; Bajorunaite, Ruta

doi:10.1080/03008200601090949

Cited by 40 publications

(26 citation statements)

References 41 publications

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“…In light of this mechanism, the high mineralization in the periosteal CB provides tissue properties which are functionally adapted to bear static occlusion loading. However, the lower E/H and higher homogeneity of tissue mineral distribution in the periosteal CB, which decrease toughness of bone tissue [32, 34, 48], would increase the risk of microcrack development leading to subchondral bone degeneration.…”

Section: Discussionmentioning

confidence: 99%

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Regional variation of bone tissue properties at the human mandibular condyle

Jeong

Kosel

et al. 2015

Bone

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The temporomandibular joint (TMJ) bears different types of static and dynamic loading during occlusion and mastication. As such, characteristics of mandibular condylar bone tissue play an important role in determining the mechanical stability of the TMJ under the macro-level loading. Thus, the objective of this study was to examine regional variation of the elastic, plastic, and viscoelastic mechanical properties of human mandibular condylar bone tissue using nanoindentation. Cortical and trabecular bone were dissected from mandibular condyles of human cadavers (9 males, 54 to 96 years). These specimens were scanned using microcomputed tomography to obtain bone tissue mineral distribution. Then, nanoindentation was conducted on the surface of the same specimens in hydration. Plastic hardness (H) at a peak load, viscoelastic creep (Creep/Pmax), viscosity (η), and tangent delta (tan δ) during a 30 second hold period, and elastic modulus (E) during unloading were obtained by a cycle of indentation at the same site of bone tissue. The tissue mineral and nanoindentation parameters were analyzed for the periosteal and endosteal cortex, and trabecular bone regions of the mandibular condyle. The more mineralized periosteal cortex had higher mean values of elastic modulus, plastic hardness, and viscosity but lower viscoelastic creep and tan δ than the less mineralized trabecular bone of the mandibular condyle. These characteristics of bone tissue suggest that the periosteal cortex tissue may have more effective properties to resist elastic, plastic, and viscoelastic deformation under static loading, and the trabecular bone tissue to absorb and dissipate time-dependent viscoelastic loading energy at the TMJ during static occlusion and dynamic mastication.

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Section: Discussionmentioning

confidence: 99%

“…This parameter is useful to examine the resistance of a material to fracture because a ductile material has a higher E/H value [32]. …”

Section: Methodsmentioning

confidence: 99%

Regional variation of bone tissue properties at the human mandibular condyle

Jeong

Kosel

et al. 2015

Bone

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“…The mechanical strength of the bone as determined by nano indentation is the same in both subtypes and independent of bone type. 7 Some individuals have normalappearing teeth and facial appearance, whereas others have DI and relative macrocephaly with frontal bossing. Enlarged ventricles reflecting the soft calvarium and a flattened midface are frequently observed.…”

Section: Oi Type IIImentioning

confidence: 99%

Osteogenesis imperfecta: Recent findings shed new light on this once well-understood condition

Basel

Steiner

2009

Genetics in Medicine

145

116

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“…Since we wanted to compress the bone to different straining levels and then image the damage in SEM as well as perform nanoindentation experiments, we could not perform wet measurements. The nanoindentation of bone under dry conditions is very common and reliability of tests have been shown to be quite applicable to understand [21][22][23]. It has also been shown earlier that measured stiffness of dry bone samples may not be reproducible, Reilly and Burstein [24].…”

Section: Sample Preparationmentioning

confidence: 99%

Effect of Compressive Straining on Nanoindentation Elastic Modulus of Trabecular Bone

et al. 2009

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Trabecular bone with its porous structure is an important compressive load bearing member. Different structural factors such as porosity, non-homogeneous deformation, varying trabeculae thickness, connectivity, and nanoscale (10 nm to 1 μm) to macroscale (~0.1 mm to 10 mm) composition hierarchy determine the failure properties of trabecular bone. While the above factors have important bearing on bone properties, an understanding of how the local nanoscale properties change at different macroscale compressive strain levels can be important to develop an understanding of how bone fails. In the present work, such analyses are performed on bovine femoral trabecular bone samples derived from a single animal. Analyses focus on measuring nanoindentation elastic moduli at three distinct levels of compressive strains in the bone samples: (1) when the samples are not loaded; (2) after the samples have been loaded to a strain level just before apparent yielding and the macroscale compression test is stopped; and (3) after the samples have been compressed to a strain level after apparent yielding and the macroscale compression test is stopped. Nanoindentation elastic modulus values are two orders of magnitude higher than the macroscale compressive elastic modulus values of all samples. A high variability in macroscale compressive elastic modulus values is observed because of porous architecture and small sample size. Nanoindentation elastic modulus values show a progressive reduction with increase in the extent of macroscale compressive deformation. Apparent yielding has a significant effect on this trend. The decrease in nanoindentation modulus value for all samples accelerates from approximately 20% before yielding to approximately 60% after yielding in comparison to the nanoindentation modulus values at 0% strain level. The level of variation in the predicted nanoindentation modulus values is the lowest for uncompressed samples (~16-18%). However, with increase in the extent of compression, the level of variation increases. It varied between 50% and 90% for the samples tested after yielding showing a widespread heterogeneity in local nanoscale structural order after apparent yielding. Scanning electron microscope (SEM) observations suggest that apparent yielding significantly destroys local nanoscale structural order. However, quantitative results suggest that a significant residual nanoscale stiffness varying from 5 GPa to 8 GPa among different samples still remains for possible repair facilitation.

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Comparison of Nanoindentation Measurements Between Osteogenesis Imperfecta Type III and Type IV and Between Different Anatomic Locations (Femur/Tibia versus Iliac Crest)

Cited by 40 publications

References 41 publications

Regional variation of bone tissue properties at the human mandibular condyle

Regional variation of bone tissue properties at the human mandibular condyle

Osteogenesis imperfecta: Recent findings shed new light on this once well-understood condition

Effect of Compressive Straining on Nanoindentation Elastic Modulus of Trabecular Bone

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