Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo

Shirzad, Hedayatollah; Shariati, Mehrdad; Rafieian-Kopaei, Mahmoud

doi:10.1016/j.intimp.2009.04.002

Cited by 77 publications

(50 citation statements)

References 24 publications

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“…These results correspond to literature data confirming the negative effect of opiates on the phagocytic activity of monocytes and neutrophils [9,4]. To summarize, obtained results put forward the COX-2 inhibitor parecoxib as a promising alternative to the opioid drugs in the perioperative analgesia.…”

Section: Resultssupporting

confidence: 91%

The effect of perioperative analgesia with omnopon and parecoxib on the endocytic activity of murine phagocytes on the model of tumor surgery

Sydor¹,

Khranovska²,

Skachkova³

et al. 2016

Biol. Stud.

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We used the model of surgical tumor removal to compare the effect of anesthesia with opioid analgesic omnopon and selective cyclooxygenase-2 inhibitor parecoxib on the endocytic activity of phagocytes of different localization sites. 50 C57/black mice were transplanted with Lewis lung carcinoma in the hind paw pad. After 22 days, the tumor paw was amputated. Analgesics (omnopon 10 mg/kg, parecoxib -20 mg/kg) were administered 30 min before the operation and once per day for 3 days after the surgery. Assessment of the endocytic activity of phagocytes was performed by FACS analysis before the surgery, at days 1 and 3 after the surgery. It was found that parecoxib analgesia maintained the endocytic activity of blood and spleen phagocytes in the postoperative period. At day 3 after the surgery in parecoxib-treated animals phagocytic activity of splenic granulocytes were 2.2 times higher compared to that in the group receiving opioid analgesia. Phagocytic indices of monocytes in parecoxib-treated mice were also 1.6 and 2.5 times higher for blood and spleen monocytes, respectively. Thus, parecoxib analgesia maintained the activity of blood and spleen phagocytes in mice after the surgical tumor removal at a much higher level as compared with the omnopon analgesia.

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Section: Resultssupporting

confidence: 91%

The effect of perioperative analgesia with omnopon and parecoxib on the endocytic activity of murine phagocytes on the model of tumor surgery

Sydor¹,

Khranovska²,

Skachkova³

et al. 2016

Biol. Stud.

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“…43 Free radicals can cause oxidative stress, which may induce damage to biomolecules, leading to many chronic diseases, such as cancer, 44 56,57 and other degenerative diseases. Antioxidant activity of pomegranate fruit has been attributed to the presence of some components like ascorbic acid and phenolic compounds, including punicalagin, punicalin, gallic acid, ellagic acid, and anthocyanins.…”

Section: Discussionmentioning

confidence: 99%

A Review Study on Punica granatum L

Shaygannia

Bahmani

Zamanzad

et al. 2015

J Evid Based Complementary Altern Med

Self Cite

174

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Punica granatum L (pomegranate) is a deciduous shrub, native to Iran. Nowadays, besides its use as a fruit, its medicinal properties have attracted the interest of researchers of many countries. Pomegranate fruit has medicinal properties such as antiinflammatory and antibacterial activities. The pomegranate seed oil has inhibitory effect on skin and breast cancers. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. Ellagic acid is one of the main components of pomegranate with phenolic structure and antioxidant activity. This review article presents the recently published findings on different aspects of this plant focusing on its medicinal properties

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“…Clinical trials began testing the impact of single substances such as vitamin E, vitamin C and beta-carotene against cancer, heart disease and others. Although free radicals contribute to chronic diseases such as cancer (6,7), diabetes (8,9), atherosclerosis (7,8), heart disease , nephrotoxicity, hepatotoxicity, cognitive (6-9) and vision loss (10) and a lot of researches, especially laboratory trials, show benefits for antioxidants against these conditions, however, long clinical trials are inconclusive and do not show that antioxidant supplements have a substantial impact on these diseases. While it is believed that substances found naturally in vegetables, fruits, and grains help …”

Section: Dear Editormentioning

confidence: 99%

“…prevent a variety of chronic diseases, it is unlikely that antioxidants in all conditions can do the same. The results of the large studies offer little evidence that taking vitamin E, vitamin C, beta-carotene, or other single antioxidants protect against these diseases (6)(7)(8)(9). Two studies even showed that taking beta-carotene may actually increase the chances of developing lung cancer in smokers (11,12).…”

Section: Introductionmentioning

confidence: 99%