Comparison of Mohs Micrographic Surgery and Wide Excision for Extramammary Paget's Disease: Korean Experience

Abstract

MMS is more effective, with lower recurrence rate than wide excision, and should be regarded as the first-line treatment for nonmetastatic EMPD.

Role of Radiotherapy as Curative Treatment of Extramammary Paget’s Disease

“…Additionally, EMPD frequently coexists with other internal malignancies; thus, a through examination to identify other malignancies should be performed before treatment (3)(4)(5)(6). Racial differences in the frequency of malignancies coexisting with EMPD have been reported, with the coexistence rate lower for Asian patients than for white patients (0-13% vs. 15-30%) (7).…”

5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease

“…However, frozen sections have a false-negative rate of 10.4%, up to as high as 40%, and is known to have no improvement in disease outcome (15,16). MMS may lower local recurrence rate (17)(18)(19)(20) but is timeconsuming and requires additional faculty for use.…”

Extramammary Paget Disease: Review of Patients Seen in a Non-Melanoma Skin Cancer Clinic

“…Hendi and colleagues 7 note that when Mohs micrographic surgery is not available, surgical management is also effective when done with wide excision; they specify 5-cm margins. Lee et al 8 found that local control after wide excision is fairly good, with an overall relative 5-year local control rate of 64.6%. Unfortunately, excision with wide margins can be disfiguring, distorting normal anatomy and leading to difficulties in wound healing.…”