5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease

Peng, Xueqing; Wei, Qian; Hou, Junyi

doi:10.5582/bst.2017.01224

Cited by 11 publications

(4 citation statements)

References 25 publications

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“…Among the 81 full-text review articles, 27 studies met the inclusion criteria. 8,9,15,21,26–47 A PRISMA flow chart is found in Supplemental Digital Content 3 , Figure S7, http://links.lww.com/DSS/B162.…”

Section: Resultsmentioning

confidence: 99%

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

2022

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Section: Resultsmentioning

confidence: 99%

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

2022

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“…ALA accumulates primarily in malignant cells, and its fluorescence is much stronger than that in normal skin. 7 We used ALA for identifying the real extension of the disease and distant scattered lesions, obtaining a complete tumor‐free resection.…”

Section: Discussionmentioning

confidence: 99%

Fluorescence‐guided surgery for non‐melanoma and melanoma skin cancer: Case series and a brief review of the literature

Bobyr

Francesca

Rizzetto

et al. 2021

Photoderm Photoimm Photomed

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Surgery is the primary mode of treatment for non-melanoma (NMSC) and melanoma skin cancer (MSC). The main purpose of surgery is to completely remove the neoplastic lesion, since the presence of residual tumor cells is considered a strong predictor of tumor recurrence, new surgical approach, and, therefore, survival. 1Fluorescence can be utilized to define tumor margins before and during surgery, improving the possibility of radical resection. More

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“…Although 5-cm resection margins are conventionally required, some authors have attempted to reduce this to 1-2.5 cm for well-demarcated lesions by the use of scouting biopsies [12,22]. Other pre-operative methods such as dermoscopy, photodynamic diagnosis, and a handheld reflectance confocal microscope have been described with varying sensitivities and specificities [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Staged pelvic exenteration followed by oblique fleur-de-lis rectus abdominis myocutaneous (OFRAM) flap and keystone flap reconstruction for extramammary Paget’s disease

et al. 2021

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Extramammary Paget's disease (EMPD) is a rare, locally aggressive cutaneous adenocarcinoma which typically involves the anogenital region. The prognosis heavily depends on early diagnosis with definitive surgical treatment. To reduce local recurrence, wide radical resection with margin control and Moh's micrographic surgery are conventionally recommended. We describe a case of a 65-year-old female with extensive perineal EMPD involving the vulva, vagina, ectocervix, urethra, and anal canal, extending to the sacral region. She required pelvic exenteration and skin resection with 5-cm margins. A rectus abdominis myocutaneous flap (OFRAM) was designed with a fleur-de-lis skin paddle, with the vertical limb extended in an oblique fashion. We name this the OFRAM design and it allows maximal recruitment of abdominal tissue for the reconstruction of massive pelvic defects. The oblique limb obliterated the pelvic floor defect after the pelvic exenteration, while the horizontal limbs were used to resurface the perineal defect. One week later, after formal histology confirmed oncologic clearance, a gluteal keystone flap was used to resurface the remnant posterior defect. We discuss the disease pathology and reconstructive options in such cases. Level of Evidence: Level V, therapeutic study.

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5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease

Cited by 11 publications

References 25 publications

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Fluorescence‐guided surgery for non‐melanoma and melanoma skin cancer: Case series and a brief review of the literature

Staged pelvic exenteration followed by oblique fleur-de-lis rectus abdominis myocutaneous (OFRAM) flap and keystone flap reconstruction for extramammary Paget’s disease

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