The aim of this randomized in vitro study is to clarify if there are differences between the dentin adhesives as well as their adhesion and fracture behaviour. The study design was based on the ISO standard TS 11405 (2003). For this purpose, ninety extracted, caries-free human molars were embedded in a plastic block, and the dentinal surfaces were dissected free. Teeth were divided into three groups (n = 30) and each treated with a different adhesive system (SYC: Syntac Classic; CSE: Clearfi l SE, CS3: Clearfi l S3). All trial teeth were coated with a cylindrical standardized test specimen (diameter: 3.0 mm, height: 3.0 mm) on buccal surfaces with an ISOconforming application aid. The aging of the samples was achieved by thermocycling (500 cycles). Thereafter, the adhesive forces (MPa) of the various dentin adhesive systems were determined by means of shear bond testing with a universal testing machine from Zwick. The samples were examined under a scanning electron microscope at 20x and 2000x magnifi cation for their fracture modes (adhesive, cohesive, mixed). Furthermore, parametric Weibull regression models were applied to evaluate whether there was a signifi cant association between shear bond strength and the used adhesive system. Weibull analysis was performed using R software (version 2.11.1, R Foundation for Statistical Computing, Vienna, Austria). Differences between groups were tested using Wald tests, and p-values below 0.05 were considered signifi cant. CSE (3.97 MPa), followed by SYC (3.02 MPa), and CS3 (2.16 MPa) had the highest bond strength averages. The result of the statistical evaluation shows statistical differences between the different groups. Mostly mixed fractures were observed. SYC (m = 6.35) was most reliably followed by CSE (m = 4.75). The lowest Weibull module scored CS3 (m = 3.91).Under the limitations of this study, it can be stated that the differences between the groups were signifi cant and the One-Step Self-Etch-system (CS3) showed the lowest values. Additionally one major problem was the acrylic application aid (split mould according to ISO/TS 11405), which may have transferred adverse forces to the specimen and which cannot be recommended for further studies.