Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease

Rossi, Giacomo; Pengo, G.; Caldín, Marco; Piccionello, Angela Palumbo; Steiner, Jörg M.; Cohen, Noah D.; Jergens, Albert E.; Suchodolski, Jan S.

doi:10.1371/journal.pone.0094699

Cited by 201 publications

(216 citation statements)

References 52 publications

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“…Selected probiotics have been shown to be effective for some gastrointestinal disorders in humans and domestic animals yet prevention of neonatal diarrhea has not been reported 27, 28. Further, successful probiotic studies have often involved inflammatory, not infectious, disorders,29, 30 raising questions of the potential efficacy of probiotics in foals given the pathophysiology of foal diarrhea. Recent advances in the knowledge of the equine intestinal microbiota could be used to design equine‐specific probiotics and further investigation of this area is required.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Schoster

Staempfli

Abrahams

et al. 2015

Veterinary Internal Medicne

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BackgroundUp to 60% of foals develop diarrhea within 6 months after birth. Preventive measures are limited but potentially probiotics could be used.ObjectiveTo evaluate the effect of a newly designed probiotic on the incidence of foal diarrhea in a randomized field trial.AnimalsSeventy‐two healthy neonatal foals.MethodsRandomized, placebo‐controlled field trial. Foals were administered a placebo or probiotic for 3 weeks and monitored for an additional week. A total of 3 fecal samples were taken from each foal at biweekly intervals. Statistical modeling was applied for comparison of incidence and duration of diarrhea and fecal shedding of Clostridium perfringens and Clostridium difficile between treatment and age groups.ResultsThe overall incidence of diarrhea was 41 of 72 (59%) and did not differ (P = 0.37) between treatment groups. Foals treated with probiotics were more likely to develop diarrhea requiring veterinary intervention (P = 0.007). Age had a significant effect on incidence of diarrhea (P < 0.001); foals 8–15 days old having the highest probability of developing diarrhea. Duration of diarrhea and soft feces were not significantly different between groups. The prevalence of C. perfringens shedding was 55% with no difference between treatment groups (P = 0.23). The prevalence of C. difficile shedding was 11%.Conclusion and Clinical ImportanceThere was no benefit of administering a 3‐week course of probiotics, but potential adverse effects were noted. Whether the probiotics lacked a clinical effect, or the choice of strains or dose was inadequate, is unknown. Clostridial shedding was not influenced by probiotics despite in vitro activity of probiotics.

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Section: Discussionmentioning

confidence: 99%

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Schoster

Staempfli

Abrahams

et al. 2015

Veterinary Internal Medicne

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“…Feed products that include probiotics can express beneficial effects such as the ability to inhibit the adhesion of the pathogens, mainly E. coli and other enteric pathogens (Coconnier et al, 1993;Zhang et al, 2012;Jahromi et al, 2016). In addition, the positive effect of probiotics on body cell immunity development in animals was documented (Zhang et al, 2003, Rossi et al, 2014Wen et al, 2014;Mousavi et al, 2015). However, few studies have been conducted to evaluate the effect of dietary probiotic mixture on performance and meat quality of pigs.…”

Section: Introductionmentioning

confidence: 99%

Effect of a dietary probiotic blend on performance, blood characteristics, meat quality and faecal microbial shedding in growing-finishing pigs

Tufarelli¹,

Crovace²,

Rossi³

et al. 2017

SA J. An. Sci.

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The current study aimed to evaluate the effect of a dietary probiotic blend on growth performance, blood characteristics, meat quality, and faecal microbial population in growing-finishing pigs in a 12-week experiment. Pigs were assigned to two dietary treatments: a control basal-diet without probiotic blend (NoPro) and a test-diet including the probiotic blend (Pro) according to pig bodyweight (BW) at the dose of 100 mg/kg of BW. Pigs fed the probiotics had higher final BW and increased average daily gain (ADG), as well as improved feed conversion ratio (FCR). Blood parameters of pigs were not affected by dietary probiotic complex. Meat crude protein and polyunsaturated fatty acids (PUFA) contents were increased in the group fed probiotics, whereas there were no significant differences in the other meat traits. Feeding of probiotics determined a decrease in faecal NH 3 -N (+15.5%) and butyric acid concentrations, whereas no effects were observed on faecal acetic acid and propionic acid. An increased faecal Lactobacillus concentration was found when pigs fed probiotic blend. Based on our findings, feeding probiotic blend enhanced growth performance and meat quality in growing-finishing pigs, and also decreased faecal NH 3 -N and butyric acid levels resulting in a viable approach to reduce animal excreta pollution.

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“…Therefore, permanent or intermittent use of antimicrobials may be needed in some cases in order to control the clinical signs. The use of a multi-strain probiotic may also be useful in this setting modifying the intestinal microenvironment and promoting the growth of beneficial microbes, which may prevent the relapse of bacterial dysbiosis and alleviate intestinal inflammation (Rossi et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Ileocolic junction resection in dogs and cats: 18 cases

Fernández

Seth

Murgia

et al. 2017

Veterinary Quarterly

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There is limited veterinary literature about dogs or cats with ileocolic junction resection and its long-term follow-up. To evaluate the long-term outcome in a cohort of dogs and cats that underwent resection of the ileocolic junction without extensive (50%) small or large bowel resection. Medical records of dogs and cats that had the ileocolic junction resected were reviewed. Follow-up information was obtained either by telephone interview or e-mail correspondence with the referring veterinary surgeons. Nine dogs and nine cats were included. The most common cause of ileocolic junction resection was intussusception in dogs (5/9) and neoplasia in cats (6/9). Two dogs with ileocolic junction lymphoma died postoperatively. Only 2 of 15 animals, for which long-term follow-up information was available, had soft stools. However, three dogs with suspected chronic enteropathy required long-term treatment with hypoallergenic diets alone or in combination with medical treatment to avoid the development of diarrhoea. Four of 6 cats with ileocolic junction neoplasia were euthanised as a consequence of progressive disease. Dogs and cats undergoing ileocolic junction resection and surviving the perioperative period may have a good long-term outcome with mild or absent clinical signs but long-term medical management may be required.

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Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease

Cited by 201 publications

References 52 publications

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Effect of a Probiotic on Prevention of Diarrhea and Clostridium difficile and Clostridium perfringens Shedding in Foals

Effect of a dietary probiotic blend on performance, blood characteristics, meat quality and faecal microbial shedding in growing-finishing pigs

Ileocolic junction resection in dogs and cats: 18 cases

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