Comparison of metabolic profile and abdominal fat distribution between karyotypically normal women with premature ovarian insufficiency and age matched controls

Ates, Seda; Yeşil, Gözde; Şevket, Osman; Molla, Taner; Yıldız, Şeyma

doi:10.1016/j.maturitas.2014.07.008

Cited by 44 publications

(39 citation statements)

References 29 publications

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“…Earlier studies have described several changes in lipids among women with POI, as early as in their 30s, similar to the present findings in climacteric women at the age of 46: higher TC (29,35), higher HDL-C (29), higher LDL-C (35) and higher triglycerides (27). There is little research on the lipid profile of women with POI in their 50s, but Daan et al (28) found no difference in TC, LDL-C or triglyceride levels between women with POI and age-matched premenopausal controls, whereas they found HDL-C levels were higher in women with POI.…”

Section: Discussionsupporting

confidence: 92%

“…Hence, we suggest that lower androgen levels may precede earlier climacterium. Some earlier studies have investigated androgen levels in postmenopausal women with POI in their 30s, compared to age-matched premenopausal women: no difference was found in the studies by Ates et al (29) or by Gulhan et al (35), whereas Daan et al (37) showed POI women to have lower testosterone and FAI. It is suggested that women with POI had lower levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate in their 50s (28).…”

Section: Discussionmentioning

confidence: 93%

“…Many studies have suggested that both natural and surgical EM and POI increase the risk of cardiovascular morbidity (24)(25)(26). There is little research on the cardiovascular risk profile of women experiencing premature menopause, but some certain risk factors have been identified, such as an unfavorable lipid profile (27), elevated C-reactive protein levels (28), increased waist circumference (28) and metabolic syndrome (29). It has been suggested that the reverse may be at play, namely that an unfavourable cardiovascular risk profile may trigger earlier menopause (30).…”

Section: A Dmentioning

confidence: 99%

See 2 more Smart Citations

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Savukoski

Mäkelä

Auvinen

et al. 2019

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Section: A Dmentioning

confidence: 99%

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Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Savukoski

Mäkelä

Auvinen

et al. 2019

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…The prevalence of POI is ~1% of women < 40 years-old, ~0.1% of women < 30 years-old, and ~0.01% of women < 20 years-old [2,3]. POI, previously described in the literature as premature ovarian failure (POF), is associated with hypoestrogenism and an increased risk of metabolic disorders [4][5][6]. POI can have different aetiologies and is found in women with both normal and abnormal karyotypes.…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance indexes in women with premature ovarian insufficiency — a pilot study

et al. 2018

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“…16 Menopausal hormone therapy (MHT) for 6 months has shown to improve the flow mediated dilatation by 2.4-fold, to the same level as healthy controls. 17 CAD has also been attributed to dyslipidemia in POI but there are conflicting results. One study has reported significantly high triglyceride levels and lower HDL cholesterol levels in comparison to controls after correction for age and body mass index (47 POI vs. 60 controls).…”

Section: Discussionmentioning

confidence: 99%

Impact of premature ovarian insufficiency on cardiovascular health

Abraham¹,

Londhe²,

Sebastian³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: The objectives of the study were to identify the causes of premature ovarian insufficiency (POI) and to assess the severity of menopausal symptoms as well as the impact on cardiovascular health in these patients.Methods: Authors did a cross sectional case control study with 100 cases and 100 age matched controls. Women <40years of age with amenorrhoea >4months and FSH >25mIU/ml were identified with POI. Women <40years with normal cycles were the controls. Causes were identified from medical records and menopausal symptoms were categorized using menopause rating score questionnaire. Hypercholesterolemia (≥200mg/dl), hypoalbuminemia (<3.5g/dl) and high sensitive C reactive protein (HS-CRP ≥3mg/dl) were assessed as the early markers of coronary artery disease. Statistical methods included Chi square test and logistic regression analysis. P value <0.05 was considered significant.Results: 64% of the patients were between 31-40 years. 66% of them were into menopause for <5 years. The cause was idiopathic in 62%. 91% had no or minimal menopausal symptoms. Hypoalbuminemia (6 versus 1, 95% CI 1.8-2.4, OR 2.1, p=0.01) and hypercholesterolemia (75 versus 51, 95%CI 2.5-3.1, OR 2.8, p= 0.001) were significantly high in cases. HS-CRP was not found to be different between the groups (59 versus 49, OR 1.5, 95%CI 0.8-2.6, p=0.2).Conclusions: In majority with POI the cause is idiopathic and menopausal symptoms are minimal. Hypoalbuminemia and hypercholesterolemia, markers of coronary artery disease, were significantly elevated in POI. Early screening for these variables within 5 years of menopause would reduce the cardiovascular mortality in these patients.

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Comparison of metabolic profile and abdominal fat distribution between karyotypically normal women with premature ovarian insufficiency and age matched controls

Cited by 44 publications

References 29 publications

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Insulin resistance indexes in women with premature ovarian insufficiency — a pilot study

Impact of premature ovarian insufficiency on cardiovascular health

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