Insulin resistance indexes in women with premature ovarian insufficiency — a pilot study

Kunicki, Michał; Rudnicka, Ewa; Skórska, Jolanta; Calik-Ksepka, Anna; Smolarczyk, Roman

doi:10.5603/gp.a2018.0062

Cited by 10 publications

(6 citation statements)

References 28 publications

(34 reference statements)

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“…Along with those mentioned above, we identified in the RA group with IR an accumulative effect of the inflammatory and lipid profiles and the magnitude of IR indexes. These measurements compare with other studies that contain evidence of insulin sensitivity/resistance assessment over a wide range of assorted populations [34,[50][51][52][53]. At this point, we could suggest that when IR has been established in RA patients, they show evidence of an unfavorable PLOS ONE metabolic and inflammatory state probably potentiated by the pathological expansion and distribution of body adipose tissue.…”

Section: Plos Onesupporting

confidence: 54%

CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis

et al. 2021

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Rheumatoid arthritis (RA) has been associated with insulin resistance (IR). Due to an excess in storage of white adipose tissue, IR has an inflammatory process that overlaps with RA. This is performed by the activation/migration of monocytes carried out by the CCR2/CCL2 and CMKLR1/RvE1 chemokines systems. Furthermore, these can potentiate chronic inflammation which is the central axis in the immunopathogenesis of RA. We evaluated the association between the relative expression of CCR2 and CMKLR1 and the serum levels of their ligands CCL2 and RvE1, in the context of adiposity status with IR as a comorbidity in RA. We studied 138 controls and 138 RA-patients classified with and without IR. We evaluated adiposity, RA activity, IR status and immunometabolic profiles by routine methods. Insulin, CCL2 and RvE1 serum levels were determined by ELISA. Relative expression of CCR2, CMKLR1 and RPS28 as constitutive gene by SYBR green RT-qPCR and 2-ΔΔCT method. Increased measurements were observed of body adiposity and metabolic status as follows: RA with IR>control group with IR>RA without IR> control group without IR. CCR2 and CMKLR1 relative expression was increased in RA without IR versus control without IR. CCR2: 2.3- and 1.3-fold increase and CMKLR1: 3.5- and 2.7-fold increase, respectively. Whereas, CCR2 expression correlates with CMKLR1 expression (rho = 0.331) and IR status (rho = 0.497 to 0.548). CMKLR1 expression correlates with inflammation markers (rho = 0.224 to 0.418). CCL2 levels were increased in the RA groups but levels of RvE1 were increased in RA without IR. We conclude that in RA with IR, the chemokine receptors expression pattern showed a parallel increase with their respective ligands. RA and IR in conjunction with the pathological distribution of body fat mass might exacerbate chronic inflammation. These results suggest that high CCL2 levels and compensatory RvE1 levels might not be enough to resolve the inflammation by themselves.

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Section: Plos Onesupporting

confidence: 54%

CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis

et al. 2021

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“…Insulin resistance was calculated using the homeostatic model assessment insulin resistance index (HOMA-IR) according to the formula (HOMA-IR = [fasting insulin fasting glucose]/22.5). Insulin resistance was ascertained when HOMA-IR > 2.5 [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…There are several data indicating a higher risk of ischemic heart disease and an increased mortality rate of cardiovascular origin among women diagnosed with POI. Additionally, several studies have implicated that affected females are at an increased risk of dyslipidemia and insulin resistance [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Does the Value of FSH Predict Severity of Metabolic Complications in Females with POI?

Kunicki

Kruszewska

Skórska

et al. 2022

JCM

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Premature ovarian insufficiency (POI) is defined as a cessation of ovarian function before the age of 40. Such early deprivation of estrogens in women may be associated with several adverse cardiovascular and metabolic consequences. The aim of this retrospective study was to investigate whether women with POI and a serum follicle-stimulating hormone (FSH) level of 25–40 I/U (Group A) have the same metabolic profile as women with POI and a serum FSH level of >40 I/U (Group B). One hundred twenty-three women were included in the study group (Group A; n = 41; Group B; n = 82). The control group comprised 77 healthy women with regular menstruation. In the age- and BMI-adjusted model, no differences were found between the groups with respect to total cholesterol, high-density lipoproteins, triglycerides, HOMA-IR, glucose, and insulin. The only significant difference was found in terms of low-density lipoprotein cholesterol (LDL-C). The highest serum concentration was found in Group B, the second highest was found in Group A, and the lowest was in the controls. In conclusion, changing the threshold of FSH required to establish a POI diagnosis may have an impact on the level of serum LDL-C.

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“…In the baseline study, HOMA-IR was not a mediator, while Gutt index was a mediator while in the present study, HOMA-IR was not a mediator, while Mc Auley was a mediator only in NHW, and Mc Auley was a moderator in OH and NHW. Kunicki et al 39 similarly in a study where measuring IR in women with premature ovarian sufficiency using different indexes found different results with different indexes of IR. This highlights the validity of the insulin resistance index measures, which might explain the differences in our results.…”

Section: Insulin Resistance Indexes and Hypertensionmentioning

confidence: 96%

Insulin Resistance, Serum Calcium and Hypertension: A Cross-Sectional Study of a Multiracial Population, and a Similarity Assessment of Results from a Single-Race Population’s Study

Nkondjock¹,

Wabo²,

Kosgey³

et al. 2021

DMSO

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Background: Recent research suggests the need to assess more ethnic disparities in hypertension (HTN). On the other hand, studies reveal impressive mortality rates due to cardiovascular diseases for some race and ethnic groups compared to others. Methods: We referred to a recent study on serum calcium (SC) and insulin resistance associated with HTN incidence to compare different race groups in the latter found relationship. We compare the current study outcomes with those from the Wu et al study. Results: From 425 participants of the National Health and Nutrition Examination Survey (NHANES) data, we found a significant association between race and hypertension; Cramer's V (0.006) = 0.21 when adjusted with non-hypertensives and hypertensives. Mc Auley index (McA) was negatively related to hypertension, r (355) = −0.24, p < 0.0001. SC associated with HTN in all race groups significance persisted only in non-Hispanic Whites after multivariate adjustments R 2 of 74.1 (p = 0.03). McA was a mediator on SC-HTN in non-Hispanic Whites (NHW) (Coef IE = 13.25, [CI] = 1.42-32.13), and a moderator in other Hispanics interaction (0.04) = 0.27 and NHW interaction (0.001) = 0.028. Conclusion: SC was associated with hypertension, similarly to the baseline study. SC and HTN association persisted in NHW compared to other race groups. Homeostasis model assessment (HOMA-IR) was not a mediator on SC-HTN, but with McA, this in NHW only.McA played a moderator role in OH and NHW. We suggest that race is a factor implicated in our findings, which may be investigated further in future research.

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Insulin resistance indexes in women with premature ovarian insufficiency — a pilot study

Cited by 10 publications

References 28 publications

CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis

CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis

Does the Value of FSH Predict Severity of Metabolic Complications in Females with POI?

Insulin Resistance, Serum Calcium and Hypertension: A Cross-Sectional Study of a Multiracial Population, and a Similarity Assessment of Results from a Single-Race Population’s Study

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