Comparison of measured and calculated radiotherapy doses in the chest region of an inhomogeneous humanoid phantom

McDermott, L. N.; Perkins, Anne E.

doi:10.1007/bf03178883

Cited by 5 publications

(4 citation statements)

References 13 publications

(32 reference statements)

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“…First, MC statistical uncertainties (often less than ±1% to 2% at 1 standard deviation) can now be reduced below experimental uncertainties in the thermoluminescent detector measurements (±1.5% to 2.5% at 1 standard deviation) commonly used in dose verifications involving anthropomorphic phantoms. (4,9,12,22,23,36) Furthermore, uncertainties associated with imperfect positioning of detectors relative to their intended position in the phantom are eliminated with MC, because the position and size of every voxel is known exactly. Another advantage of MC is that it provides a large number of comparison points-a number considerably exceeding the number that can be accurately measured.…”

Section: Verification Of Tps Calculations: Comparison With MCmentioning

confidence: 99%

Evaluation of the analytical anisotropic algorithm in an extreme water–lung interface phantom using Monte Carlo dose calculations

Gagne

Zavgorodni

2007

J Applied Clin Med Phys

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Our study compares the performance of the analytical anisotropic algorithm (AAA), a new superposition–convolution algorithm recently implemented in the Eclipse (Varian Medical Systems, Palo Alto, CA) Integrated Treatment Planning System (TPS), to that of the pencil beam convolution (PBC) algorithm in an extreme (C‐shaped, horizontal and vertical boundaries) water–lung interface phantom. Monte Carlo (MC) calculated dose distributions for a variety of clinical beam configurations at nominal energies of 6‐MV and 18‐MV are used as benchmarks in the comparison. Dose profiles extracted at three depths (4, 10, and 16 cm), two‐dimensional (2D) maps of the dose differences, and dose difference statistics are used to quantify the accuracy of both photon‐dose calculation algorithms. Results show that the AAA is considerably more accurate than the PBC, with the standard deviation of the dose differences within a region encompassing the lung block reduced by a factor of 2 and more. Confidence limits with the AAA were 4% or less for all beam configurations investigated; with the PBC, confidence limits ranged from 3.5% to 11.2%. Finally, AAA calculations for the small 4×4 18‐MV beam, which is poorly modeled by PBC (dose differences as high as 16.1%), provided the same accuracy as the PBC model of the 6‐MV beams commonly acceptable in clinical situations.PACS number: 87.53.Bn

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Section: Verification Of Tps Calculations: Comparison With MCmentioning

confidence: 99%

Evaluation of the analytical anisotropic algorithm in an extreme water–lung interface phantom using Monte Carlo dose calculations

Gagne

Zavgorodni

2007

J Applied Clin Med Phys

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“…Simple physical phantoms, often just slabs of tissue equivalent material, are still critical for standardization procedures; however, anthropomorphic phantoms, which mimic the human body in shape and heterogeneous density distribution, receive significant usage especially in analysis of dose delivery to specific organs (16–20). The widespread usage of small animal models has spurred development of physical phantoms of mice as well.…”

Section: Introductionmentioning

confidence: 99%

Scattered Dose Calculations and Measurements in a Life-Like Mouse Phantom

et al. 2017

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Anatomically accurate phantoms are useful tools for radiation dosimetry studies. In this work, we demonstrate the construction of a new generation of life-like mouse phantoms in which the methods have been generalized to be applicable to the fabrication of any small animal. The mouse phantoms, with built-in density inhomogeneity, exhibit different scattering behavior dependent on where the radiation is delivered. Computer models of the mouse phantoms and a small animal irradiation platform were devised in Monte Carlo N-Particle code (MCNP). A baseline test replicating the irradiation system in a computational model shows minimal differences from experimental results from 50 Gy down to 0.1 Gy. We observe excellent agreement between scattered dose measurements and simulation results from X-ray irradiations focused at either the lung or the abdomen within our phantoms. This study demonstrates the utility of our mouse phantoms as measurement tools with the goal of using our phantoms to verify complex computational models.

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“…Simple physical phantoms, often just slabs of tissue equivalent material, are still critical for standardization procedures; however, anthropomorphic phantoms, which mimic the human body in shape and heterogeneous density distribution, receive significant usage especially in analysis of dose delivery to specific organs (16)(17)(18)(19)(20). The widespread usage of small animal models has spurred development of physical phantoms of mice as well.…”

Section: Introductionmentioning

confidence: 99%