Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw

Minami, Yoshiyuki; Ogura, Ichiro

doi:10.1097/mnm.0000000000001624

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…For a definitive diagnosis, histological evaluation is necessary. Recently, diffusion‐weighted MR imaging 13 and SPECT/CT 14 have been applied for jaw pathologies. We consider that the diffusion‐weighted MR imaging and SPECT/CT can be an effective tool for the quantitative evaluation of jaw pathologies.…”

Section: Discussionmentioning

confidence: 99%

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

Ogura

Okada

Mizuhashi

et al. 2023

Oral Science International

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BackgroundBreast carcinoma is a common tumor in women, but it rarely metastasizes to the oral region.Case presentationAn 83‐year‐old woman presented with numbness and pain on the right side of the mandible. The patient's medical history included breast cancer that was treated with surgery. Panoramic radiograph showed a radiolucency with ill‐defined margin in the right mandible. CT images showed an osteolytic lesion with cortical bone destruction in the right mandible. Histopathological diagnosis was invasive ductal carcinoma.ConclusionDental practitioner should be aware that metastatic tumor of the mandible may occur in the patient with breast cancer.

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Section: Discussionmentioning

confidence: 99%

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

Ogura

Okada

Mizuhashi

et al. 2023

Oral Science International

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“…In advanced stages or before surgical intervention, the use of multidetector CT (MDCT), magnetic resonance imaging (MRI), or bone scintigraphy is beneficial in determining the disease extent, establishing treatment options, and monitoring the response to therapy [13]. Of these imaging techniques, single-photon emission computed tomography (SPECT) shows promise for the early detection and monitoring of MRONJ activity in affected bone [14].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT—A Prospective Comparative Study

Reinert,

Pfannenberg,

Gückel

et al. 2024

Diagnostics

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Objectives: The purpose of this study was to investigate the imaging characteristics of medication-related osteonecrosis of the jaw (MRONJ) using [18F]fluoride positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose (FDG) PET/magnetic resonance imaging (MRI) for preoperative assessment and to correlate them with microarchitectural and histomorphometric data with respect to clinical findings. Methods: Twelve patients (five female; mean age 75 ± 7.6 yr) with symptomatic MRONJ underwent both scans on the same day, and imaging findings were used to plan surgical interventions for seven patients. Bone tracer uptake was classified as high, medium, or low, and surgical samples were evaluated using Micro-CT and histomorphometric analysis. Results: CT showed medullary sclerosis in all patients, and MRI revealed gadolinium enhancement in four patients. PET imaging revealed remarkably elevated [18F]fluoride uptake and moderately increased [18F]FDG uptake in MRONJ compared to healthy jawbones, with both differences being statistically significant. [18F]fluoride uptake was associated with necrosis, bacteria, and inflammatory tissue. Micro-CT data did not show significant differences, but histomorphometric analysis revealed higher osteocyte and lacunae densities in the high [18F]fluoride uptake group, and more necrotic bone in the medium [18F]fluoride uptake group. Bacteria were observed in all areas. Conclusions: In summary, [18F]fluoride PET accurately identified MRONJ extent, revealing functional changes in jawbone remodeling not visible on CT. [18F]FDG PET showed differences in bone and soft tissue, though less pronounced. This method aids in evaluating disease activity and guiding treatment planning, requiring further research for optimal surgical approaches based on tracer uptake.

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Role of preoperative SPECT/CT standardized uptake values in medication-related osteonecrosis of the jaw: a preliminary study of SPECT/CT in relation to cone-beam CT and histopathological findings of the resected bone of mandibulectomy

Kobayashi

Tezuka

Ono

et al. 2023

Egypt J Radiol Nucl Med

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Background SPECT/CT has been applied for preoperative planning of MRONJ. Furthermore, the SUV using bone SPECT/CT has enabled quantitative analysis of jaw lesions. This study aimed to evaluate the role of preoperative SPECT/CT SUVs in MRONJ, especially SPECT/CT in relation to CBCT and histopathological findings of the resected bone of mandibulectomy. The preliminary study was conducted on five MRONJ patients who underwent mandibulectomy after SPECT/CT. Results The SUVmax and SUVmean of MRONJ in all cases (19.5 ± 5.6 and 5.5 ± 0.8) were significantly higher than those of right side of the MRONJ (8.5 ± 2.0 and 2.7 ± 0.5) and left side of the MRONJ (7.2 ± 1.6 and 2.7 ± 0.4), respectively. The CBCT of all cases showed osteolytic and sclerotic internal texture and sequestrum. The histopathological characteristics of all cases showed necrotic bone and granulation tissue with the bone circumference surrounded by inflammatory cells. Conclusions The preliminary results indicated a difference between MRONJ and right and left sides of the MRONJ in SPECT/CT SUVs. The SUVs has enabled quantitative analysis for surgical planning of MRONJ.

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Comparison of maximum and mean standardized uptake values of jaw pathologies with bone SPECT/CT: an especial focus on medication-related osteonecrosis of the jaw

Cited by 6 publications

References 26 publications

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

Panoramic radiography and computed tomography of metastatic breast carcinoma in the mandible: Report of a case

Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT—A Prospective Comparative Study

Role of preoperative SPECT/CT standardized uptake values in medication-related osteonecrosis of the jaw: a preliminary study of SPECT/CT in relation to cone-beam CT and histopathological findings of the resected bone of mandibulectomy

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