Comparison of magnetic resonance urography to dimercaptosuccinic acid scan for the identification of renal parenchyma defects in children with vesicoureteral reflux

Cerwinka, Wolfgang H.; Grattan‐Smith, J. Damien; Jones, Richard A.; Haber, Michael; Little, Stephen B.; Blews, David E.; Williams, Joseph P.; Kirsch, Andrew J.

doi:10.1016/j.jpurol.2013.09.016

Cited by 30 publications

(10 citation statements)

References 28 publications

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“…Mindful of the potential higher sensitivity to radiation, imaging could alternatively be carried out using MR (Supplemental Figure 3). Although there is no published experience specifically in FA, MR-urography has been used by us and others for reflux and assessment of renal function, avoiding ionizing radiation exposure [16, 17]. In our cohort, renal impairment at diagnosis was seen in children with severe phenotype including early severe haematological complications.…”

Section: Discussionmentioning

confidence: 87%

Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management

et al. 2018

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BackgroundFanconi anaemia (FA) is an inherited disease with bone marrow failure, variable congenital and developmental abnormalities, and cancer predisposition. With improved survival, non-haematological manifestations of FA become increasingly important for long-term management. While renal abnormalities are recognized, detailed data on patterns and frequency and implications for long-term management are sparse.MethodsWe reviewed clinical course and imaging findings of FA patients with respect to renal complications in our centre over a 25-year period to formulate some practical suggestions for guidelines for management of renal problems associated with FA.ResultsThirty patients including four sibling sets were reviewed. On imaging, 14 had evidence of anatomical abnormalities of the kidneys. Two cases with severe phenotype, including renal abnormalities, had chronic kidney disease (CKD) at diagnosis. Haematopoietic stem cell transplantation was complicated by significant acute kidney injury (AKI) in three cases. In three patients, there was CKD at long-term follow-up. All patients had normal blood pressure.ConclusionsEvaluation of renal anatomy with ultrasound imaging is important at diagnostic workup of FA. While CKD is uncommon at diagnosis, our data suggests that the incidence of CKD increases with age, in particular after haematopoietic stem cell transplantation. Monitoring of renal function is essential for management of FA. Based on these long-term clinical observations, we formulate some practical guidelines for assessment and management of renal abnormalities in FA.Electronic supplementary materialThe online version of this article (10.1007/s00467-018-3952-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 87%

Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management

et al. 2018

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“…MRU combines high spatial resolution with assessment of renal function and drainage. Several studies comparing MRU to DMSA renal scintigraphy for the detection of pyelonephritis and renal scarring have shown MRU to be at least equivalent or superior to DMSA renal scintigraphy [27][28][29]. MRU can distinguish among acute pyelonephritis, renal scarring, and renal dysplasia [30].…”

Section: Discussion Of Procedures By Variantmentioning

confidence: 99%

“…A study by Sattari et al [39] suggests that CT is more accurate than DMSA renal scintigraphy in detecting involvement with acute pyelonephritis in adult patients. Cerwinka et al [28] found MRU to be superior to DMSA renal scintigraphy in the identification of renal scarring in children with vesicoureteral reflux and a history of pyelonephritis; furthermore, DMSA renal scintigraphy also appears to underestimate the degree of renal parenchymal damage. Other studies comparing MRU to DMSA renal scintigraphy for the detection of pyelonephritis and renal scarring have shown MRU to be at least equivalent or superior to DMSA renal scintigraphy [27,29].…”

Section: Discussion Of Procedures By Variantmentioning

confidence: 99%

ACR Appropriateness Criteria® Acute Pyelonephritis

Imaging¹,

Nikolaidis

Dogra

et al. 2018

Journal of the American College of Radiology

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Pyelonephritis refers to infection involving the renal parenchyma and renal pelvis. In most patients, uncomplicated pyelonephritis is diagnosed clinically and responds quickly to appropriate antibiotic treatment. If treatment is delayed, the patient is immunocompromised, or for other reasons, microabscesses that form during the acute phase of pyelonephritis may coalesce, forming a renal abscess. Patients with underlying diabetes are more vulnerable to complications, including emphysematous pyelonephritis in addition to abscess formation. Additionally, diabetics may not have the typical flank tenderness that helps to differentiate pyelonephritis from a lower urinary tract infection. Additional high-risk populations may include those with anatomic abnormalities of the urinary tract, vesicoureteral reflux, obstruction, pregnancy, nosocomial infection, or infection by treatment-resistant pathogens. Treatment goals include symptom relief, elimination of infection to avoid renal damage, and identification of predisposing factors to avoid future recurrences. The primary imaging modalities used in patients with pyelonephritis are CT, MRI, and ultrasound.

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“…Furthermore, MRI may be even superior to DMSA in detecting renal scars due to its high spatial and contrast resolution. It offers a higher specificity in the differentiation among the possible causes of photopenic DMSA defects …”

Section: Imaging Techniques In Renal Transplant Follow‐upmentioning

confidence: 99%

Imaging in pediatric renal transplantation

Damasio

Müller

Piaggio

et al. 2017

Pediatric Transplantation

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Renal transplantation is the therapy of choice in children with ESKD. Radiological investigations are required in both pre- and post-transplant assessment, although there is paucity of both consensus-based statements and evidence-based imaging guidelines in pediatric renal transplantation. The phases of pediatric ESKD management that require imaging are pretransplantation recipient assessment and post-transplantation surveillance for detection of potential complications. We present suggestions for imaging algorithms for both pre- and post-transplant assessment in pediatric renal transplant recipients.

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Comparison of magnetic resonance urography to dimercaptosuccinic acid scan for the identification of renal parenchyma defects in children with vesicoureteral reflux

Cited by 30 publications

References 28 publications

Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management

Patterns and frequency of renal abnormalities in Fanconi anaemia: implications for long-term management

ACR Appropriateness Criteria® Acute Pyelonephritis

Imaging in pediatric renal transplantation

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