Imaging in pediatric renal transplantation

Damasio, Maria Beatrice; Müller, Lil-Sofie Ording; Piaggio, Giorgio; Marks, Stephen D.; Riccabona, Michael

doi:10.1111/petr.12885

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…In the practical recommendations of the European Association of Urologists, after the widespread introduction of ultrasound with colour Doppler mapping into the world practice, the routine use of DRSG to assess the functioning of the transplant is not recommended [14]. But in the paediatric population, DRSG with [ 99m Tc] Tc-MAG3 is recommended for evaluation of excretory function or when the urological complication (urine leakage) is suspected [18].…”

Section: Methods Of the Diagnosis Of Transplantation Complications Pl...mentioning

confidence: 99%

Significance of nuclear medicine methods for diagnosis and predicting the course of renal transplantation complications

Satyr,

Noverko,

Pantus

et al. 2024

CSIC

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Renal transplantation is a replacement-based therapeutic method in end-stage kidney failure.It is based on the interdisciplinary collaboration between scientists and clinicians, which match together the achievements of surgery, immunology, and radiation diagnostics. After transplantation the complications appear, which can be associated with status of the graft, the immunological factors of compatibility between the donor and the recipient, the surgical intervention. Early diagnosis and forehanded treatment of such complications is important, as it helps to evaluate and predict the functionality of the graft. In this article we discuss the complications after kidney transplantation: the reasons of their occurrence, pathogenesis, clinical features, and radiation imaging signs. The opportunities of the radiology methods for the differential diagnostics of complications which appear before, during or after the surgery, are shown. We pay the main attention to the nuclear medicine methods, especially the dynamic renal scintigraphy (DRSG) as a method for the evaluation of graft functionality. This is a safe, accessible and non-invasive method for evaluation the quantitative and qualitative parameters of kidney function. DRSG consequently characterizes the perfusion, the extraction and the excretion in the studied organ. We display the standard DRSG protocols using [99mTc] Tc-MAG3 and [99mTc] Tc-DTPA radiopharmaceuticals. We analyze investigations of kinetic perfusion and parenchymal DRSG parameters and their importance for differential diagnosis of complications, prognosis on delayed and slow graft function, short-term and long-term graft functionality assessment. We make an accent on the prognostic importance of the dynamic changes visible on DRSG. We discuss the perspectives of further development of scintigraphic methods for the assessment of kidney grafts. It is related to the implementation of high-quality 3-dimentional visualization, newest radiopharmaceuticals. We conclude the importance of the nuclear medicine as an element of multidisciplinary approach in transplantology.

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Section: Methods Of the Diagnosis Of Transplantation Complications Pl...mentioning

confidence: 99%