Comparison of ligands of differing denticity and basicity for the in vivo chelation of aluminium and gallium

Clevette, David J.; Orvig, Chris

doi:10.1016/s0277-5387(00)80564-1

Cited by 68 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different speciation models [29][30][31][32][33][34][35][36] have been reported in the literature. As concerns the h.m.m.…”

Section: Absorbed Almentioning

confidence: 99%

See 1 more Smart Citation

Demonstration of the Importance of Metal Ion Speciation in Bioactive Systems

Kiss¹,

Odani²

2007

Bulletin of the Chemical Society of Japan

View full text Add to dashboard Cite

This paper gives insight into chemical speciation. After a brief introduction, the methods available to study solution state of metal ions and the importance of speciation in biology are discussed through different examples. Speciation of toxic Al III , beneficial Cu II and Ca II and potentially medicinal Pd II and VO IV in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in an organism. The relevance of ternary complex formation with endogenous biomolecules is emphasised. The importance of the biospeciation of Al III ion in its transport and involvement in neurological disorders, of the actual chemical form of the insulin-mimetic VO IV complexes in its biological occurrence and Ca II in mineralization/demineralization processes is discussed. The role of time, i.e., the kinetic aspects of biospeciation, is discussed in the case of the transport of Al III and Cu II and some Pd II complexes (models of the anticancer Pt II complexes) in blood serum.

show abstract

“…Different speciation models [29][30][31][32][33][34][35][36] have been reported in the literature. As concerns the h.m.m.…”

Section: Absorbed Almentioning

confidence: 99%

“…Al III binders. [29][30][31][32][33][34][35][36] Daydé et al, 29 Jackson, 30 and Harris 31 have proposed inorganic phosphate as the main Al III binder, whereas Clevette and Orvig, 32 Duffield et al, 33 and Ö hman and Martin 34 have suggested that citrate (Cit) is the only important l.m.m. binder.…”

Section: Absorbed Almentioning

confidence: 99%

Demonstration of the Importance of Metal Ion Speciation in Bioactive Systems

Kiss¹,

Odani²

2007

Bulletin of the Chemical Society of Japan

View full text Add to dashboard Cite

show abstract

“…The first two bands appearing in the Fe(III)-5-iodouracil and Fe(III)-5-iodouracil-histidine complexes at 512, 490 nm and 393, 389 nm, respectively, may be assigned to 6 A 1g 4 T 1g and 4 T 2g transition.…”

Section: Magnetic Moments and Electronic Spectramentioning

confidence: 97%

“…It is accepted that the antitumour activity is due to inhibition of DNA synthesis in cancer cells [5]. Aluminium(III) has been shown to bind with the chelating ligands in a simple human blood plasma model [6]. It has been established that the liability of chromium(III) complexes with distorted octahedral geometry is the possible factor for its active role in biological systems [7].…”

Section: Introductionmentioning

confidence: 99%

Aluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity

Singh

Narang

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…mucin (Exley, 1998), citrate (Ohman, 1988;Tapparo et al, 1995;Sheikh-Osman, et al, 1993) and lactate (Tapparo et al, 1995;Corain et al, 1992)) in simple solutions and equilibrium conditional Alligand stability constants are known (Martell et al, 1990;Sillen and Martell, 1971). Aluminium-ligand stability constants and/or pAl (-log [Al 3+ ]) are good measures of Al-ligand binding affinities (Martin, 1992;Clevette and Orvig, 1990). Nonetheless, establishing the relative importance of these Al-ligand interactions under intestinal conditions (e.g.…”

Section: Introductionmentioning

confidence: 99%