Aluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity

Abstract

H-uridine incorporation in DNA and RNA replication, respectively, at a dose of 5 mg/mL.

Simulation of a tetramer form of 5-iodouracil: The vibrational spectra and molecular structure in the isolated and in the solid state by using DFT calculations

“…5-IU is an important antimetabolite-like other halogenated uracils, and some of its derivatives have antitumor [13] and anti-HCMV viruses [14] activity, and they have been used in the treatment of hepatitis B infections [15]. Aluminum(III), chromium(III) and iron(III) complexes with 5-IU have also antitumor activity [16]. Some 5-IU based nucleoside analogues were found to be selective inhibitors of herpes simplex viruses [17].…”

Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis

“…C-doped porous carbon nitrides prepared from uracil mediated molecule with cyanuric acid showed effective electron hole separation and broaden the light absorption range [4]. The uracil complexes of several metal ions, such as Fe(III), Co(III), Ni(II), Cu(II), Zn(II), Cd(II), and Pd(II) have been reported earlier [5][6][7][8][9][10][11][12][13]. Literature review reveals that uracil behaves as monobasic bidentate ligand bonding through N(1) and C(4)=O [8].…”

“…A number of monomeric metal complexes of uracil have been reported in the literature in which the chelation of uracil occurs either through N(3) and C(2)=O, or through N(3) and C(4)=O [9,10]. However, the polymeric mixed ligand complexes of uracil or substituted uracil generally involve N(1) and C(4)=O in bonding with metal ion [11][12][13]. The uracil-metal complexes can have square planar and octahedral geometries [3,4].…”

Synthesis, spectral and thermal studies of some polymeric mixed ligand uracil–hydrazide complexes with transition metal ions

“…However, the polymeric mixed ligand complexes of uracil or substituted uracil generally involve N(1) and C(4)=O in bonding with metal ion [13,14,27]. Since, several polymeric chelates of transition metal ions have been reported to show antialgal, antifungal, antibacterial and antitumour activities [28,29], the present compounds are also expected to be biologically active.…”

“…Ternary complexes of various metal ions with nucleobases, nucleosides, nucleotides and other ligands have been reported by several workers [10][11][12], as they provide the models for various metal-activated reactions in biological systems. The ternary complexes involving 5-halouracils and amino acid like L-histidine have been investigated [13,14].…”