Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers

Koudas, Vassilis; Nikolaou, Alexandra; Hourdaki, Eugenia; Giakoumaki, Stella G.; Roussos, Panos; Bitsios, Panos

doi:10.1007/s00213-009-1508-5

Cited by 19 publications

(18 citation statements)

References 57 publications

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“…For this reason it’s impossible to compare our results (lower light/darkness ratio, lower FHO/RP ratio in infrared light, lower pupil size in yellow-green light, greater pupil size in darkness of TMD group) apparently in disagreement with above cited [42], [50] using light reflex. Moreover, we didn’t use psychometric scales to measure mood and psychological characteristics of subjects.…”

Section: Discussioncontrasting

confidence: 71%

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Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

et al. 2012

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The role of the autonomic nervous system (ANS) was recently investigated in Temporomandibular disorders (TMD). Several authors argue that in subjects with TMD there is a dysregulation of ANS. Recent literature support that Pupillometry is a simple non-invasive tool to study ANS. The aim of this study was to investigate the relationship between TMD and ANS activity using pupillometry recording in Infrared light at rest Mandible Position (RP); Infrared light at Forced Habitual Occlusion (FHO); Yellow-green light at RP; Yellow-green light at FHO. Forty female subjects were enrolled: 20 case patients showed TMD based on the Research Diagnostic Criteria for TMD, and 20 control patients, aged matched, had no signs or symptoms of TMD. Statistical analysis was performed on average pupil size. Ratio between pupil size in FHO and RP (FHO/RP ratio) and yellow-green and infrared (light/darkness ratio) lighting were carried out. Within group differences of pupil size and of “ratio” were analyzed using a paired t test, while differences of pupil size between groups were tested using an unpaired t test. Statistical comparisons between groups showed no significant differences of absolute values of pupil dimension in RP and FHO, both in yellow-green and in infrared lighting. In addition, there were no significant differences within groups comparing RP and FHO in yellow-green light. In within group comparison of pupil size, differences between RP and FHO were significant in infrared conditions. Control subjects increased, whereas TMD patients decreased pupil size at FHO in infrared lightening. FHO/RP ratio in darkness and light/darkness ratio in RP were significantly different between groups. Taken together, these data suggest that TMD subjects have an impairment of the sympathetic-adrenergic component of the ANS to be activated under stress. The present study provides preliminary pupillometric data confirming that adrenergic function is dysregulated in patients with TMD.

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Section: Discussioncontrasting

confidence: 71%

“…Dilator muscle contraction is mediated by alpha-adrenergic receptors and inhibition or relaxation may be exercised by muscarinic receptors and, although not yet fully documented, by beta-adrenergic innervations [46], [47], [48], [49], [50].…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

et al. 2012

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“…Mydriasis has been consistently described for DMT (Rosenberg et al 1963;1964;, whereas myosis has been observed for the 5-HT 2 antagonist ketanserin (Koudas et al 2009). Increases in pupillary diameter were reported for ayahuasca by Callaway et al (1999), who administered a lower dose (0.48 mg DMT/kg) and compared changes vs. baseline values, and by Santos et al (in press) for a higher 1.0 mg DMT/kg dose.…”

Section: Discussionmentioning

confidence: 96%

Pharmacology of ayahuasca administered in two repeated doses

et al. 2011

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“…Future studies could further explore the discriminative stimulus effects of tramadol using alternative and more complex designs. It is possible that the monoamine reuptakeinhibition activity of tramadol influenced miotic effects because serotonergic drugs also produce miosis (Fanciullacci, Sicuteri, Alessandri, & Geppetti, 1995;Koudas et al, 2009). The use of double-dissociation techniques that also block tramadol's nonopioid effects (e.g., monoamine reuptake-inhibition activity) would help clarify these mixed-action effects and the relationship with miosis.…”

Section: Discussionmentioning

confidence: 99%

Mu opioid mediated discriminative-stimulus effects of tramadol: An individual subjects analysis

Strickland

Rush

Stoops

2015

Journal of the Experimental Analysis of Behavior

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Drug discrimination procedures use dose-dependent generalization, substitution, and pretreatment with selective agonists and antagonists to evaluate receptor systems mediating interoceptive effects of drugs. Despite the extensive use of these techniques in the nonhuman animal literature, few studies have used human subjects. Specifically, human studies have not routinely used antagonist administration as a pharmacological tool to elucidate the mechanisms mediating the discriminative stimulus effects of drugs. This study evaluated the discriminative-stimulus effects of tramadol, an atypical analgesic with monoamine and mu opioid activity. Three human subjects first learned to discriminate 100 mg tramadol from placebo. A range of tramadol doses (25 to 150 mg) and hydromorphone (4 mg) with and without naltrexone pretreatment (50 mg) were then administered to subjects after acquiring the discrimination. Tramadol produced dose-dependent increases in drug-appropriate responding and hydromorphone partially or fully substituted for tramadol in all subjects. These effects were attenuated by naltrexone. Individual subject records indicated a relationship between mu opioid activity (i.e., miosis) and drug discrimination performance. Our findings indicate that mu opioid activity may mediate the discriminative-stimulus effects of tramadol in humans. The correspondence of generalization, substitution, and pretreatment findings with the animal literature supports the neuropharmacological specificity of the drug discrimination procedure.

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Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers

Cited by 19 publications

References 57 publications

Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

Pharmacology of ayahuasca administered in two repeated doses

Mu opioid mediated discriminative-stimulus effects of tramadol: An individual subjects analysis

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