Comparison of K+ Channel Families

Taura, Jaume; Kircher, Daniel M.; Gameiro‐Ros, Isabel; Slesinger, Paul A.

doi:10.1007/164_2021_460

Cited by 16 publications

(27 citation statements)

References 406 publications

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“…SLO channels, also known as KSper, have a major role in regulating capacitation- induced hyperpolarization in the sperm cells [ 23 , 24 , 83 , 84 , 91 ]. SLO channels belong to the family of Ca 2+ -activated K + channels (KCa) and are composed of a pore-forming α subunit, and three types of auxiliary subunits [ 25 , 85 , 112 , 113 , 114 ] ( Table 2 ). The four known α subunits are named SLO1, SLO2.1, SLO2.2 and SLO3, and among them, SLO1 and SLO3 are abundantly expressed in mammalian spermatozoa [ 15 , 83 , 84 , 85 , 90 ].…”

Section: Sperm Capacitation and Hyperpolarizationmentioning

confidence: 99%

The Role of Sperm Membrane Potential and Ion Channels in Regulating Sperm Function

Pinto

Odriozola

Candenas

et al. 2023

IJMS

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During the last seventy years, studies on mammalian sperm cells have demonstrated the essential role of capacitation, hyperactivation and the acrosome reaction in the acquisition of fertilization ability. These studies revealed the important biochemical and physiological changes that sperm undergo in their travel throughout the female genital tract, including changes in membrane fluidity, the activation of soluble adenylate cyclase, increases in intracellular pH and Ca2+ and the development of motility. Sperm are highly polarized cells, with a resting membrane potential of about −40 mV, which must rapidly adapt to the ionic changes occurring through the sperm membrane. This review summarizes the current knowledge about the relationship between variations in the sperm potential membrane, including depolarization and hyperpolarization, and their correlation with changes in sperm motility and capacitation to further lead to the acrosome reaction, a calcium-dependent exocytosis process. We also review the functionality of different ion channels that are present in spermatozoa in order to understand their association with human infertility.

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Section: Sperm Capacitation and Hyperpolarizationmentioning

confidence: 99%

The Role of Sperm Membrane Potential and Ion Channels in Regulating Sperm Function

Pinto

Odriozola

Candenas

et al. 2023

IJMS

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“…With more than 80 different genes encoding channel-forming subunits (α subunits) K + channels represent the most diverse group of selective ion channels [4]. So far, four different families are known: voltage-gated (K v ), inward rectifying (K ir ), Ca 2+ -or Na + -activated (K Ca / K Na ), and two pore domain K + channels (K 2P ) [5].…”

Section: Introduction -The K 2p Channel Familymentioning

confidence: 99%

The Special One: Architecture, Physiology and Pharmacology of the TRESK Channel

Schreiber

Düfer

Seebohm

2022

Cell Physiol Biochem

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The TWIK-related spinal cord K+ channel (TRESK) is part of the two-pore domain K+ channel family (K2P), which are also called leak potassium channels. As indicated by the channel family name, TRESK conducts K+ ions along the concentration gradient in a nearly voltage-independent manner leading to lowered membrane potentials. Although functional and pharmacological similarities exist, TRESK shows low sequence identity with other K2P channels. Moreover, the channel possesses several unique features such as its sensitivity to intracellular Ca2+ ions, that are not found in other K2P channels. High expression rates are found in immune-associated and neuronal cells, especially in sensory neurons of the dorsal root and trigeminal ganglia. As a consequence of the induced hyperpolarization, TRESK influences neuronal firing, the release of inflammatory mediators and the proliferation of distinct immune cells. Consequently, this channel might be a suitable target for pharmacological intervention in migraine, epilepsy, neuropathic pain or distinct immune diseases. In this review, we summarize the biochemical and biophysical properties of TRESK channels as well as their sensitivity to different known compounds. Furthermore, we give a structured overview about the physiological and pathophysiological impact of TRESK, that render the channel as an interesting target for specific drug development.

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“…K + channels regulate a cell’s excitability and resting membrane potential and determine the shape of the action potential waveform in cells such as neurons and myocytes ( Mathie et al, 2021 ). K + channel families are classified into four groups: voltage-gated K (Kv), calcium-activated (K Ca ), inwardly rectifying K (Kir), and two-pore domain potassium (K2P) channels ( Taura et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Rajabian

Babaei

et al. 2022

Front. Pharmacol.

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Potassium ion (K+) channels are pore-forming transmembrane proteins that control the transport of K+ ions. Medicinal plants are widely used as complementary therapies for several disorders. Studies have shown that the modulation of K+ channels is most likely involved in various pharmacological effects of medicinal plants. This review aimed to evaluate the modulatory effects of medicinal plants and their active constituents on K+ channels under pathological conditions. This systematic review was prepared according to the Preferred Reporting Items for the Systematic Reviews and Meta-analyses (PRISMA) 2020 guideline. Four databases, including PubMed, Web of Science, embase, and Scopus, were searched. We identified 687 studies from these databases, from which we selected 13 in vivo studies for the review by using the Population, Intervention, Comparison, Outcomes, Study (PICOS) tool. The results of the 13 selected studies showed a modulatory effect of medicinal plants or their active constituents on ATP-sensitive potassium channels (KATP), and small (SKCa) and large (BKCa) conductance calcium-activated K+ channels in several pathological conditions such as nociception, brain ischemia, seizure, diabetes, gastric ulcer, myocardial ischemia-reperfusion, and hypertension via possible involvement of the nitric oxide/cyclic GMP pathway and protein kinase. K+ channels should be considered as significant therapeutic milestones in the treatment of several diseases. We believe that understanding the mechanism behind the interaction of medicinal plants with K+ channels can facilitate drug development for the treatment of various K+ channel-related disorders.

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Comparison of K+ Channel Families

Cited by 16 publications

References 406 publications

The Role of Sperm Membrane Potential and Ion Channels in Regulating Sperm Function

The Role of Sperm Membrane Potential and Ion Channels in Regulating Sperm Function

The Special One: Architecture, Physiology and Pharmacology of the TRESK Channel

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

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