Comparison of isoflurane and propofol–fentanyl anaesthesia in a swine model of asphyxia

Kurita, Tadayoshi; Morita, Koji; Kazama, Tomiei; Sato, Shigehito

doi:10.1093/bja/aeg259

Cited by 25 publications

(16 citation statements)

References 18 publications

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“…Anaesthesia was maintained with 100-125 mg kg À1 min À1 of propofol (Diprivan 1 ) delivered by a Baxter syringe pump. Compared with other anaesthetic regimens, total intravenous anaesthesia with propofol is less likely to cause cardiovascular [7] or pulmonary [8] dysfunction, and less decrease in arterial or mixed venous oxygen partial pressure [9], in swine. Inhalation anaesthetics such as halothane may not have been appropriate for these studies, since muscle-cell damage (as indicated by increased creatine phosphokinase [CPK]) can result from such use [10].…”

Section: Anaesthesia and Experimental Set-upmentioning

confidence: 95%

Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures

Jauchem

Sherry

Fines

et al. 2006

Forensic Science International

110

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Section: Anaesthesia and Experimental Set-upmentioning

confidence: 95%

Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures

Jauchem

Sherry

Fines

et al. 2006

Forensic Science International

110

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“…the epidural ropivacaine and a lower inspired isoflurane concentration in the AL-group. The MAP range reported for anaesthetised pigs is 9.98-13.3 kPa 13 , and for isoflurane anaesthetised pigs 9.6-11.1 kPa with the end-tidal isoflurane concentration approximately 0.85 % 6 . The values MAP reported by Riebold 13 were somewhat higher compared with the values observed in this investigation, but were similar to the values of Malavasi 8 .…”

Section: Discussionmentioning

confidence: 92%

“…Cardiovascular stability as evaluated from increases in heart rate was therefore better maintained in the ALgroup after ropivacaine epidural when subjected to abdominal surgery. The decrease in blood pressure could be regarded as an adverse effect but this should be seen in the context that the blood pressure was higher in the ALgroup compared with the A-group and that the pressures were within range of pressures reported for isoflurane-anaesthetised pigs 6,8 . Possible complications reported in humans after the combined administration of inhalation anaesthesia and lumbar epidural anaesthesia were bradycardia and hypotension 1,10,16 .…”

Section: Discussionmentioning

confidence: 93%

Cardiovascular effects of lumbar epidural anaesthesia in isoflurane-anaesthetised pigs during surgical removal of the liver

Stegmann¹

2009

J. S. Afr. Vet. Assoc.

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In humans the combined administration of epidural anaesthesia and inhalation anaesthesia may result in cardiovascular instability associated with decreases in heart rate and blood pressure. Anaesthesia was induced with a combination of midazolam/ketamine in 18 female pigs with a mean body weight of 24.9 ± 5.9 kg scheduled for surgical removal of the liver. After tracheal intubation, anaesthesia was maintained on a circle rebreathing circuit with isoflurane. Epidural anaesthesia was administered with ropivacaine (AL-group, n = 8) at 0.2 m /kg of a 7.5 mg/m solution to the anaesthetised animals. The A-group (n = 10) received isoflurane anaesthesia only. The vaporiser was set at 2.5 % for the A-group and 1.5 % for the AL-group. Heart rate, invasive systolic, diastolic , and mean arterial blood pressure were monitored. Comparisons were made between treatments and within treatments comparing variables during surgical preparation and abdominal surgery. Differences between treatments were not statistically significant (P > 0.05) during surgical preparation or during abdominal surgery. For within treatment groups, the differences between surgical preparation and abdominal surgery were statistically significant (P < 0.05) for heart rate in the A-group, but not statistically significant (P > 0.05) for the other variables. It is concluded that abdominal surgery may be associated with statistically significant changes in heart rate in isoflurane-anaesthetised pigs and that the combined administration of epidural ropivacaine may prevent statistically significant changes in HR during abdominal surgery.

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“…Although some studies favor intravenous maintenance of anaesthesia (9,10), in terms of safety and hemodynamic stability, one must remember that new inhaled anaesthetics such as sevoflurane offer both cardioprotection and ease of administration (11,12). A balanced approach (13) using both intravenous and inhaled agents has been proposed and probably offers the potential benefits of both techniques.…”

Section: Discussion Discussionmentioning

confidence: 99%

A New Protocol of Inhalatory Induction of Anaesthesia in Experimental Swine Surgery. A Pilot Study

Popescu¹,

David²,

Pautov³

et al. 2016

JTMR

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Induction of Anaesthesia in swine may prove to be difficult because of the differences in anatomy and physiology. Intubation of large animals is especially difficult due to the length of the snout and the relative difficulty of obtaining adequate relaxation. The present study is aimed to compare two induction techniques for tracheal intubation in pigs. The secondary aim was to assess the effectiveness of a new anaesthetic protocol for experimental surgery. For this, six female pigs underwent two liver surgeries each. Induction of anaesthesia was performed either using intravenous propofol and fentanyl (IV intravenous group) or by using Sevoflurane (inhalatory group). The attending anaesthesiologist was asked to grade the ease of intubation from a scale between 1 and 5. Orotracheal intubation was easier to obtain in the inhalatory group (p=0.00) and a smaller number of attempts were necessary (p=0.00). A lower End-tidal CO2 after intubation was observed in the inhalatory group (p=0.05). There were no differences in both systolic (p=0.11) and diastolic (p=0.72) arterial pressure and heart rate (p=0.16) after induction of anaesthesia between the two groups. Maintenance of anaesthesia was made using Sevoflurane and boluses of fentanyl for adequate analgesia while no muscle relaxants were used. Intravenous morphine and ketoprofen were used for postoperative analgesia. In conclusion, volatile induction of anaesthesia is safe and offers a better view of the larynx in large swine, while the proposed anaesthetic protocol provides adequate anaesthesia for the surgeons and assures comfort to the animals.

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Comparison of isoflurane and propofol–fentanyl anaesthesia in a swine model of asphyxia

Abstract: Although TIVA is less prone than isoflurane anaesthesia to primary cardiovascular depression leading to asphyxia, TIVA is associated with reduced effectiveness of CPR in which resuscitation because of asphyxic haemodynamic depression occurs.

Cited by 25 publications

References 18 publications

Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures

Acidosis, lactate, electrolytes, muscle enzymes, and other factors in the blood of Sus scrofa following repeated TASER® exposures

Cardiovascular effects of lumbar epidural anaesthesia in isoflurane-anaesthetised pigs during surgical removal of the liver

A New Protocol of Inhalatory Induction of Anaesthesia in Experimental Swine Surgery. A Pilot Study

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