Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals

Garrido, Iris P.; Roy, Debashis; Calviño, Ramón; Vázquez‐Rodríguez, José Manuel; Aldama, Guillermo; Cosı́n-Sales, Juan; Quiles, Juan; Gaze, David; Kaski, Juan Carlos

doi:10.1016/j.amjcard.2003.09.019

Cited by 54 publications

(29 citation statements)

References 9 publications

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“…In agreement with other studies [3,11,13] we have found a significant elevation of IMA values in ACS compared to NICP group. Furthermore, IMA was significantly higher in the subgroup of AMI than in UA, suggesting that IMA actually reflects the extent of myocardial ischemia.…”

Section: Discussionsupporting

confidence: 82%

Value of ischemia modified albumin (IMA) for diagnosis of acute coronary syndrome (ACS) in patients with acute chest pain

Dragojević¹,

Kisić²,

Mirić³

et al. 2014

Praxis Med

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The aim of this study was to evaluate the diagnostic accuracy of ischemia modified albumin (IMA) alone, or in combination with cardiac troponin T (cTnT) and electrocardiogram (ECG) findings for diagnosis of acute coronary syndrome (ACS). The study included patients with acute chest pain suggestive on ACS, recruited within 6 hours from onset. Patients were classified in ACS group and non-ischemic chest pain group (NICP). Of 84 patients, 49 were diagnosed with ACS and 35 with NICP. IMA was significantly higher in ACS group (p<0.0001). The area under receiver operating curve for IMA in ACS diagnosis was 0.95 (p<0.0001). Sensitivity and specificity of IMA for ACS diagnosis were 89.8% and 91.4%, respectively. IMA significantly (p<0.05) improved the sensitivity of ECG and cTnT, alone, and in combination. Sensitivity and negative predictive value of combination of IMA, ECG and cTnT for diagnosis of ACS were 100%. IMA is useful for diagnosis of ACS, in combination with ECG and cTnT.

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Section: Discussionsupporting

confidence: 82%

Value of ischemia modified albumin (IMA) for diagnosis of acute coronary syndrome (ACS) in patients with acute chest pain

Dragojević¹,

Kisić²,

Mirić³

et al. 2014

Praxis Med

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“…16 A recent study 17 involving patients with symptoms suggestive of ACS but with normal or nondiagnostic ECGs who came to the emergency department within 3 hours of chest pain documented outcomes at 30 days of ACS (unstable angina or MI with non-ST-segment elevation) or non-ischemic chest pain. They measured IMA at presentation and reported positive (LR 2.95, 95% CI 1.91-4.56) and negative (LR 0.33, 95% CI 0.21-0.52) likelihood ratios using a threshold of 93.5 U/mL.…”

Section: Discussionmentioning

confidence: 99%

Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome

Worster

Devereaux²,

Heels‐Ansdell³

et al. 2005

Canadian Medical Association Journal

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“…Moreover, in the percutaneous coronary intervention model, IMA production is higher in patients without collateral vessels than in those with collateral circulation; thus, IMA possibly reflects a protective effect of collateral vessels against percutaneous coronary intervention-induced myocardial ischemia (4 ). IMA also appears to be useful for ruling out acute coronary syndrome in patients attending the emergency department with chest pain suggestive of myocardial ischemia (5 ).…”

confidence: 99%

Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

Roy¹,

Quiles²,

Sharma³

et al. 2004

Clinical Chemistry

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102

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Background: Ischemia-modified albumin (IMA) is a new marker of myocardial ischemia, there is concern that IMA concentrations may be affected by ischemia occurring in tissues other than the myocardium. Methods: We assessed 23 consecutive patients (15 males; mean age, 67 years) with typical leg claudication and documented peripheral vascular disease (PVD). All patients underwent both treadmill-exercise stress testing to induce leg ischemia and dobutamine stress echocardiography 1 week apart for the assessment of myocardial ischemia. Blood samples for IMA measurements were obtained at baseline, immediately after peak exercise/stress, and 1 h after exercise/stress. Statistical analysis was performed with the ANOVA repeated-measures test. Results: Compared with baseline, mean (SD) IMA was significantly lower after the induction of skeletal muscle ischemia and returned to baseline values at 1 h: baseline, 74.6 (15.6) kilounits/L; peak stress, 69.5 (14.0) kilounits/L (P <0.0001 vs baseline); 1 h after stress, 75.9 (15.7) kilounits/L (P <0.0001 vs peak stress; P ‫؍‬ 0.3 vs baseline). Baseline, peak stress, and 1-h poststress IMA concentrations were inversely correlated with the anklebrachial index after exercise (r ‫؍‬ ؊0.4; P <0.05). None of the patients showed regional wall motion abnormalities during dobutamine stress echocardiography, and IMA concentrations remained unchanged from baseline. There were no differences in baseline [74.6 (15.6) vs 72.7 (11.5) kilounits/L; P ‫؍‬ 0.6], peak stress, or poststress

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Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals

Cited by 54 publications

References 9 publications

Value of ischemia modified albumin (IMA) for diagnosis of acute coronary syndrome (ACS) in patients with acute chest pain

Value of ischemia modified albumin (IMA) for diagnosis of acute coronary syndrome (ACS) in patients with acute chest pain

Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome

Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

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