Comparison of intravenous ibuprofen and paracetamol efficiency in soft tissue injuries: A randomized, double-blind study

Yalçınlı, Sercan; Kiyan, Güçlü Selahattin; Can, Özge

doi:10.1016/j.ajem.2020.06.063

Cited by 5 publications

(14 citation statements)

References 16 publications

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“…Included studies’ pain scores ranged from 2.7 to 9.2 (mean 7.6). In 24 trials,9–14 16–30 36–38 the change in pain scores from T0 to T30 was reported, and all trials except one29 reported that all groups (paracetamol, NSAIDs or opioids) achieved clinically significant reductions in pain scores from T0 to T30. Key data were missing from 25 papers, and the lead authors were contacted to request the information,8–32 but no authors replied to requests for data.…”

Section: Resultsmentioning

confidence: 99%

“…IVP was administered as a single dose of 1 g in 100 mL NS (100 ml normal saline) in 26 trials8–13 15–19 21–30 32 36–38 and at a dose of 15 mg/kg in one trial 20. The infusion rate for the administration of IVP was as a rapid bolus infusion in three trials,11 12 24 slow infusion over 5–20 min in 16 trials,8 10 13 16 18 19 21 22 25 26 29–32 36–38 and not mentioned for 8 trials 9 14 15 17 20 23 27 28. Doses of morphine were 0.1 mg/kg in 12 trials,9 13 19–23 25–28 37 5 mg/mL in 1 trial30 and 10 mg in 2 trials 18 31…”

Section: Resultsmentioning

confidence: 99%

“…Of the 27 studies included in the review, 20 trials8–13 15 17–21 23–28 32 36 were assessed to have a high or unclear risk of bias, and 7 trials14 16 22 29 30 37 38 were assessed to have a low risk of bias using the ROB V.2 tool. The domains assessed as having some concern or a high risk of bias were randomisation process (22 studies), deviation from intended intervention (19 studies), bias due to missing outcome data (17 studies), bias in the measurement of outcome (18 studies) and bias in the selection of reported outcome (17 studies) (risk of bias table, online supplemental appendix 2).…”

Section: Resultsmentioning

confidence: 99%

“…After full analysis, 13 trials were excluded (figure 1). Key data were missing from 25 papers, and the lead authors were contacted to request the information 8–32…”

Section: Methodsmentioning

confidence: 99%

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Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic review and meta-analysis

et al. 2023

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ObjectiveParacetamol, non-steroidal anti-inflammatory drugs (NSAIDs) and opiates/opioids, administered parenterally via intravenous or intramuscular route, are widely used to provide analgesia for patients with moderate to severe pain. This systematic review and meta-analysis evaluated the level of analgesia provided by intravenous paracetamol (IVP) alone compared with NSAIDs (intravenous or intramuscular), or opioids (intravenous) alone in adults attending the ED with acute pain.MethodsTwo authors independently searched PubMed (MEDLINE), Web of Science, Embase (OVID), Cochrane Library, SCOPUS and Google Scholar (3 March 2021–20 May 2022) for randomised trials without any language or date restriction. Clinical trials were evaluated using the Risk of Bias V.2 tool. The primary outcome was mean difference (MD) for pain reduction at 30 min (T30) post analgesia delivery. The secondary outcomes were MD in pain reduction at 60, 90 and 120 min; the need for rescue analgesia; and the occurrence of adverse events (AEs).ResultsTwenty-seven trials (5427 patients) were included in the systematic review and 25 trials (5006 patients) in the meta-analysis. There was no significant difference in pain reduction at T30 between the IVP group and opioids (MD −0.13, 95% CI −1.49 to 1.22) or IVP and NSAIDs (MD −0.27, 95% CI −1.0 to 1.54. There was also no difference at 60 min, IVP group versus opioid group (MD −0.09, 95% CI −2.69 to 2.52) or IVP versus NSAIDs (MD 0.51, 95% CI 0.11 to 0.91). The quality of the evidence using Grading of Recommendations, Assessments, Development and Evaluations methodology was low for MD in pain scores.The need for rescue analgesia at T30 was significantly higher in the IVP group compared with the NSAID group (risk ratio (RR): 1.50, 95% CI 1.23 to 1.83), with no difference found between the IVP group and the opioid group (RR: 1.07, 95% CI 0.67 to 1.70). AEs were 50% lower in the IVP group compared with the opioid group (RR: 0.50, 95% CI 0.40 to 0.62), whereas no difference was observed in the IVP group compared with the NSAID group (RR: 1.30, 95% CI 0.78 to 2.15).ConclusionIn patients presenting to the ED with a diverse range of pain conditions, IVP provides similar levels of pain relief compared with opiates/opioids or NSAIDs at T30 post administration. Patients treated with NSAIDs had lower risk of rescue analgesia, and opioids cause more AEs, suggesting NSAIDs as the first-choice analgesia and IVP as a suitable alternative.PROSPERO registration numberCRD42021240099.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…After full analysis, 13 trials were excluded (figure 1). Key data were missing from 25 papers, and the lead authors were contacted to request the information 8–32…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic review and meta-analysis

et al. 2023

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“…In addition to intravenous paracetamol, which is frequently used in our country in recent years, intravenous ibuprofen as a NSAID that can be used preemptively, has also started to be used. Yalçınlı et al stated that intravenous ibuprofen is more effective than paracetamol in soft tissue injuries in patients admitted to emergency department [12] . On the other hand, Erdogan Kayhan et al showed that intravenous ibuprofen did not change the opioid consumption compared to paracetamol, but it reduced the severity of pain in patients who had bariatric surgery [13] .…”

Section: Discussionmentioning

confidence: 99%

Karotis Arter Stenozunda Cerrahi Endarterektomi ile Endovasküler Stent İmplantasyonunun Orta ve Geç Dönemde Morbidite ve Mortalite Sonuçlarının Karşılaştırılması

Bermede¹,

Baytaş²

2021

GKDA Derg

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Objectives: The aim of this study is to compare the effects of preemptive intravenous ibuprofen and paracetamol on acute pain scores, opioid consumption and patient satisfaction in patients who will undergo endovascular laser ablation under general anesthesia. Methods: After induction, 1 g Paracetamol for Group P or 800 mg Ibuprofen for Group I was administered as a slow infusion by a separate intravenous route. Both drugs were followed by a repeat dose every 6 h until discharge. Visual analogue scale (VAS) was used for pain intensity at PACU and after the first, second, sixth hour after surgery. In case of acute pain (VAS ≥ 40) 1 mg intravenous morphine was used as a rescue drug. VAS scores, length of stay, total opioid consumption and patient satisfaction status was evaluated before discharge. Results: A total of 82 patients (42 in Group P and 40 in Group I) were included. There was no difference between the VAS scores. Total morphine consumption was 0.33 ± 0.47 in Group P, and 0.30 ± 0.43 in Group I (p = 0.42). Hospital length of stay was 6.4 ± 1.7 hours in Group P and 6.2 ± 1.4 hours in Group I (p = 0.51). Patient satisfaction status evaluated at discharge was found to be similar. Conclusion: There is no difference between preemptive intravenous paracetamol and ibuprofen in patients undergoing EVLA under general anesthesia in terms of postoperative acute pain scores and opioid consumption. Both drugs can be safely applied in this type of surgery.

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Comparison of ibuprofen and dexketoprofen in the management of migraine-related headache in the emergency department

Şafak

Çorbacıoğlu

Korucu

et al. 2022

Notfall Rettungsmed

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Comparison of intravenous ibuprofen and paracetamol efficiency in soft tissue injuries: A randomized, double-blind study

Cited by 5 publications

References 16 publications

Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic review and meta-analysis

Comparison of intravenous paracetamol (acetaminophen) to intravenously or intramuscularly administered non-steroidal anti-inflammatory drugs (NSAIDs) or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic review and meta-analysis

Karotis Arter Stenozunda Cerrahi Endarterektomi ile Endovasküler Stent İmplantasyonunun Orta ve Geç Dönemde Morbidite ve Mortalite Sonuçlarının Karşılaştırılması

Comparison of ibuprofen and dexketoprofen in the management of migraine-related headache in the emergency department

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