Comparison of intense pulsed light and near‐infrared light in the treatment of dry eye disease: a prospective randomized study

Ren, Xiaotong; Chou, Yilin; Wang, Yuexin; Chen, Yanyan; Liu, Ziyuan; Li, Xuemin

doi:10.1111/aos.14833

Cited by 10 publications

(9 citation statements)

References 48 publications

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“…Ren et al 41 developed a randomized clinical trial to evaluate the benefits of IPL+MGX and NIL+MGX. Patients underwent three sessions at 4-week intervals.…”

Section: Discussionmentioning

confidence: 99%

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Pulsed Light Therapy in the Management of Dry Eye Disease: Current Perspectives

Ribeiro¹,

Marta²,

Ramalhão³

et al. 2022

OPTH

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To review the indications and efficacy of Intense Pulsed Light (IPL) application in the treatment of Meibomian Gland Dysfunction (MGD). Its main purpose is to describe its physiology, efficacy, indications, and adverse effects. Patients and Methods: A two database (PubMed, EMBASE) search was performed from July 2017 to July 2022 using the MeSH terms ("Intense Pulsed Light" AND ("Meibomian Gland Dysfunction" OR "Dry Eye"). We included randomized studies and systematic reviews with meta-analysis. Exclusion criteria were non-randomized trials, studies enrolling non-MGD dry eye disease, and other works older than 5 years. Results: Current literature shows that IPL is an effective and safe treatment modality for severe dry eye. Available evidence shows improvement of symptoms and objective indicators, such as noninvasive breakup time, thickness of lipid layer, and Schirmer test. However, our review concluded that the beneficial effects of IPL may lose some efficacy at 6-months after the initial session, and subsequent sessions may be required. Thus, IPL treatment should not be considered as first-line therapy for MGD but instead as an adjuvant option to the standard of care. The optimal treatment modality remains unknown and should be tailored according to each patient's phenotype, clinician's experience, and available technology. There is evidence that IPL treatment may down-regulate proinflammatory markers (such as interleukin (IL) 6, IL17a, IL-1) and Prostaglandin E2 (PGE2). Conclusion: MGD is a multifactorial disease and IPL treatment seems a promising treatment modality. Despite this, more evidence is needed to study its benefits -since this is an emerging technology, it is expected an increase in comparative studies in the following years, with longer follow-up periods, which may enable more precise conclusions about this treatment modality.

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“…Ren et al 41 developed a randomized clinical trial to evaluate the benefits of IPL+MGX and NIL+MGX. Patients underwent three sessions at 4-week intervals.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, these results may suggest an improvement in inflammation and meibomian gland quality in patients suffering from MGD. 40 Ren et al 41 developed a randomized clinical trial to evaluate the benefits of IPL+MGX and NIL+MGX. Patients underwent three sessions at 4-week intervals.…”

mentioning

confidence: 99%

Pulsed Light Therapy in the Management of Dry Eye Disease: Current Perspectives

Ribeiro¹,

Marta²,

Ramalhão³

et al. 2022

OPTH

View full text Add to dashboard Cite

show abstract

“…There are few randomized control, masked trials which have studied the effect of IPL on MGD and evaporative dry eye. [ 21 , 24 , 25 ] The significantly improved tear film stability in this study ( P < 0.005) suggests that IPL + LLLT has an effect on the meibomian gland outflow both in the quantity and quality of meibum secreted. The results suggest a cumulative benefit of applying three treatments with significant improvement of tear breakup time and discomfort score over a period of 3 months in the study subjects as compared to controls.…”

Section: Discussionmentioning

confidence: 59%

A randomized controlled study evaluating outcomes of intense pulsed light and low-level light therapy for treating meibomian gland dysfunction and evaporative dry eye

D’Souza

James

Koul

et al. 2023

Indian Journal of Ophthalmology

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Purpose: This randomized, controlled, blinded study evaluates the efficacy of intense pulsed light (IPL) therapy with low-level light therapy (LLLT) in the treatment of meibomian gland dysfunction (MGD) and evaporative dry eye (EDE) compared to a control group. Methods: Hundred patients with MGD and EDE were randomized into control (50 subjects, 100 eyes) and study group (50 subjects, 100 eyes). The study group underwent three sittings of IPL with LLLT 15 days apart and were followed up 1 month and 2 months after the last treatment sitting. The control group underwent sham treatment and was followed up at the same intervals. The patients were evaluated at baseline and 1 month and 3 months (post 1st treatment) for dry eye. Schirmer’s test and tear breakup time (TBUT), OSDI, meibomian gland expression, and meibography. Results: The study group showed significant improvement in OSDI scores (P < 0.0001) compared to the control group and a significant improvement in TBUT (P < 0.005) compared to the control group. There was no change in schirmer’s test and an improvement in the meibomian gland expression but not significant. Conclusion: The results show that a combined therapy of IPL with LLT is effective in treating MGD with EDE compared to controls, and repeated treatment sessions have a cumulative effect on the disease outcomes.

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“…The studies were excluded for the following reasons: theoretical research (15), no clinical outcomes (13), and no RCT (18). Finally, 15 RCTs 10–24 involving 1,142 patients (2,284 eyes) met the inclusion criteria and were included in this meta-analysis. The article screening process is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%