Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Miao, Sen; Yan, Rong; Jia, Yu-Song; Pan, Zhiqiang

doi:10.1097/icl.0000000000000934

Cited by 7 publications

(2 citation statements)

References 33 publications

(48 reference statements)

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“…Treatment usually consists of four consecutive sessions at three-week intervals, followed by adjuvant maintenance treatment every three to six months 5859. While a 2020 Cochrane review presented equivocal results,60 more recent clinical studies have demonstrated improvements in signs and symptoms of dry eye disease at one and three months after treatment completion,5861 with benefits lasting up to one year 5254. IPL therapy is considered safe and well tolerated.…”

Section: What Emerging Technologies Exist For Dry Eye Disease?mentioning

confidence: 99%

Dry eye disease management

Safir,

Twig,

Mimouni

2024

BMJ

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Section: What Emerging Technologies Exist For Dry Eye Disease?mentioning

confidence: 99%

Dry eye disease management

Safir,

Twig,

Mimouni

2024

BMJ

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“…Light and heat effects are common for treating MGD and other ocular surface diseases related to the eyelid. When conventional drug therapies fail to manage such diseases effectively under the eyelid tissue, targeted treatment and management of the affected tissues through light and heat penetration can be a viable alternative with promising results [ 20 ]. Intense pulsed light (IPL) uses a specific spectrum of visible light to generate heat that can reduce the inflammatory response and prevent the growth of new capillaries.…”

Section: Introductionmentioning

confidence: 99%

The photothermal effect of intense pulsed light and LipiFlow in eyelid related ocular surface diseases: Meibomian gland dysfunction, Demodex and blepharitis

Li,

Huang,

Fang

et al. 2024

Heliyon

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Diamond Bur Microblepharoexfoliation Combined with Intense Pulse Light and Meibomian Gland Expression for Evaporative Dry Eye: A Short-term Controlled Clinical Trial

Ballesteros-Sánchez,

Sánchez-González,

Gutiérrez-Ortega

et al. 2024

Ophthalmol Ther

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Introduction To assess the efficacy and safety of the combination of microblepharoexfoliation (MBE), intense pulse light (IPL) and meibomian gland expression (MGX) for treatment of meibomian gland dysfunction (MGD). Methods This was a prospective, parallel-control trial conducted from April 2022 to January 2023. Participants were assigned to receive either three sessions of MBE-IPL-MGX treatment and home-based therapy (treatment group) or home-based therapy alone (control group). Outcome measures were assessed at baseline and after 2-month follow-up. Results Seventy eyes of 70 patients were enrolled. MBE-IPL-MGX treatment achieved better improvements than home-based therapy in ocular surface disease index (OSDI) and symptom assessment in dry eye (SANDE) scores, noninvasive tear film break-up time (NIBUT), lipid layer grade (LLG), loss area meibomian gland (LAMG) and meibomian gland yielding secretion score (MGYSS). The mean differences between the two groups were as follows: OSDI (– 11.23 ± 4.68 points, P < 0.001), SANDE (– 24.63 ± 13.41 points, P < 0.001), NIBUT (1.3 ± 1.57 s, P = 0.033), LLG (0.4 ± 0.04 points, P = 0.003), LAMG (– 2.85 ± 1.69%, P = 0.023) and MGYSS (7.5 ± 2.32 points, P < 0.001). In addition, the increment (Δ) of MGYSS after MBE-IPL-MGX treatment was significantly higher in MGD grades 2 and 3 (all P < 0.001). Conclusions MBE-IPL-MGX treatment is an effective and well-tolerated procedure that improves dry eye symptoms and signs as well as meibomian gland secretions in patients with MGD. In addition, this treatment is recommended for MGD grades 2 and 3.

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Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 7 publications

References 33 publications

Dry eye disease management

Dry eye disease management

The photothermal effect of intense pulsed light and LipiFlow in eyelid related ocular surface diseases: Meibomian gland dysfunction, Demodex and blepharitis

Diamond Bur Microblepharoexfoliation Combined with Intense Pulse Light and Meibomian Gland Expression for Evaporative Dry Eye: A Short-term Controlled Clinical Trial

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