Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose

Ede, Karin I. van; Andersson, Patrik L.; Gaisch, Konrad P.J.; Berg, Martin van den; Duursen, Majorie B.M. van

doi:10.1007/s00204-013-1186-2

Cited by 11 publications

(15 citation statements)

References 20 publications

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“…In the present subjects, the most contributed congeners to TEQ-PCDDs/Fs in breast milk were 1,2,3,7,8-PentaCDD (34%), 2,3,4,7,8-PentaCDF (18%), and 1,2,3,6,7,8-HexaCDF (14%), while the contribution rate of TCDD was 12% of TEQ-PCDDs/Fs. These congeners, particularly 2,3,4,7,8-PentaCDF, have different toxic effects compared with TCDD in human tissue or cells [ 17 , 18 ]. Thus, the effects of TEQ-PCDDs/Fs on motor coordination might be caused by other PCDDs/Fs congeners than TCDD.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up

et al. 2016

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Dioxin concentrations remain elevated in the environment and in humans residing near former US Air Force bases in South Vietnam. Our previous epidemiological studies showed adverse effects of dioxin exposure on neurodevelopment for the first 3 years of life. Subsequently, we extended the follow-up period and investigated the influence of perinatal dioxin exposure on neurodevelopment, including motor coordination and higher cognitive ability, in preschool children. Presently, we investigated 176 children in a hot spot of dioxin contamination who were followed up from birth until 5 years old. Perinatal dioxin exposure levels were estimated by measuring dioxin levels in maternal breast milk. Dioxin toxicity was evaluated using two indices; toxic equivalent (TEQ)-polychlorinated dibenzo-p-dioxins/furans (PCDDs/Fs) and concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Coordinated movements, including manual dexterity, aiming and catching, and balance, were assessed using the Movement Assessment Battery for Children, Second Edition (Movement ABC-2). Cognitive ability was assessed using the nonverbal index (NVI) of the Kaufman Assessment Battery for Children, Second Edition (KABC-II). In boys, total test and balance scores of Movement ABC-2 were significantly lower in the high TEQ- PCDDs/Fs group compared with the moderate and low exposure groups. NVI scores and the pattern reasoning subscale of the KABC-II indicating planning ability were also significantly lower in the high TCDD exposure group compared with the low exposure group of boys. However, in girls, no significant differences in Movement ABC-2 and KABC-II scores were found among the different TEQ-PCDDs/Fs and TCDD exposure groups. Furthermore, in high risk cases, five boys and one girl highly exposed to TEQ-PCDDs/Fs and TCDD had double the risk for difficulties in both neurodevelopmental skills. These results suggest differential impacts of TEQ-PCDDs/Fs and TCDD exposure on motor coordination and higher cognitive ability, respectively. Moreover, high TEQ-PCDDs/Fs exposure combined with high TCDD exposure may increase autistic traits combined with developmental coordination disorder.

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Section: Discussionmentioning

confidence: 99%

Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up

et al. 2016

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“…As a consequence, systemic REPs for these congeners based on a skin or plasma concentration are found to be higher when compared to the intake REPs (Fig. 1 b–e) (DeVito et al 1997 ; Van Ede et al 2013 , 2014a ). For these congeners, it is clear that the systemic REPs are closer to the in vitro REPs than to the intake REPs.…”

Section: In Vitro-derived Reps As Predictors For In Vivo Systemic Repmentioning

confidence: 91%

“…In this respect, studies using primary cultures and cell lines of rodent but in particular human cells may provide relevant information that can be used for human risk assessment if based on systemic concentrations. To assess whether indeed in vitro-derived REPs are more comparable to systemic REPs, we combined intake REPs and in vitro REPs from the 2004 REP database (Haws et al 2006 ) with the very few in vivo studies in which intake REPs as well as systemic REPs were determined (Haws et al 2006 ; DeVito et al 2000 ; Van Ede et al 2013 , 2014a ). These data are presented in Fig.…”

Section: In Vitro-derived Reps As Predictors For In Vivo Systemic Repmentioning

confidence: 99%

“…The boxplots; in vivo—intake—Haws et al and in vitro—rodent—Haws et al represent data from the 2004 REP database (Haws et al 2006 ). The boxplots; in vivo—intake—this review and in vivo—systemic—this review represent data from one to four different studies in which the potency of the congener is determined based on either the administered (intake) dose or a systemic (plasma or skin) concentration (DeVito et al 1997 , 2000 ; Van Ede et al 2013 , 2014a ). The number above the boxplot represents the number of REPs.…”

Section: In Vitro-derived Reps As Predictors For In Vivo Systemic Repmentioning

confidence: 99%

“…Several studies already showed that for some congeners, blood-based REPs could be significantly different from those based on oral (intake) doses. This suggests that these “intake” REPs for hazard characterization might lead to misinterpretation of the risk when applied to blood concentrations (DeVito et al 1997 , 2000 ; van Ede et al 2013 , 2014a ). Another important potential pitfall in the current WHO-TEFs comes from the fact that these are mostly based on rodent studies, but are ubiquitously applied for human risk assessment.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of relative effect potencies (REPs) for dioxin-like compounds to derive systemic or human-specific TEFs to improve human risk assessment

2016

Self Cite

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Toxic equivalency factors (TEFs) are generally applied for estimating human risk of dioxins and dioxin-like compounds using systemic (e.g., blood) levels, even though these TEFs are established based on intake doses in rodent studies. This review shows that systemic relative effect potencies (REPs) can deviate substantially from intake REPs, but are similar to in vitro-derived REPs. Interestingly, the in vitro REPs for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) and 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) are up to one order of magnitude higher than their in vivo REPs and WHO-TEFs, based on oral intake. In addition, clear species-differences in in vitro REPs were apparent for some congeners. Especially the human-derived REP for polychlorinated biphenyl 126 is one to two orders of magnitude lower than rodent REPs and its current WHO-TEF. Next, suggested adapted systemic or human-specific TEFs for these congeners were applied to calculate changes in systemic TEQ concentrations in studies from the USA, Germany and Japan and compared with either the JECFA TDI or USEPA RfD of TCDD. Overall, the effect of such TEF changes for these three congeners on total TEQ roughly balances each other out in the general population. However, results may be different for situations in which a specific group of congeners dominates. For those congeners that show a distinct deviation between either intake and systemic REPs or between rodent- and human-based in vitro REPs, we propose that especially REPs derived from human-based in vitro models are weighted more heavily in establishing systemic or human-specific TEF values to improve human health risk assessment.

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Bioaccumulation of mercury and polychlorinated dibenzo-p-dioxins and dibenzofurans in salty water organisms

Liao

Liu

2015

Environ Monit Assess

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Mercury and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) accumulate in organisms through food webs and exert potentially toxic effects on aquatic organisms and humans. This study examined the levels of mercury and PCDD/Fs in organisms and sediment samples collected from a saltwater pond at the An-Shun site, a chloralkali factory that shut down in Tainan City, Taiwan. It was also a pentachlorophenol production plant. After the factories were shut down in the 1980s, mercury and PCDD/Fs contamination remained, posing severe health hazards. The correlation between PCDD/Fs congener accumulation patterns in distinct fish organs and the sediment was evaluated. Mercury and PCDD/Fs levels in all the fish samples exceeded food safety limits, and the concentrations of mercury and PCDD/Fs in each species were closely correlated (n = 12, Spearman's rank correlation [R] = 0.811, p < 0.01). The mercury concentrations were positively but non-significantly correlated with the weight (n = 11, R = 0.741, p < 0.01) and length (n = 11, R = 0.618, p < 0.05) of the species. The fish likely accumulated the contaminants through ingestion of other organisms or the sediment. However, after the pollutants entered a fish, they exhibited distinct accumulation patterns because of their differing chemical properties. Specifically, the mercury concentration was correlated with organism weight and length, whereas the PCDD/Fs concentration was associated with organ lipid content. The study results are valuable for assessing the health risks associated with ingesting mercury- and PCFF/F-contaminated seafood from the study site.

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Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose

Cited by 11 publications

References 20 publications

Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up

Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up

Evaluation of relative effect potencies (REPs) for dioxin-like compounds to derive systemic or human-specific TEFs to improve human risk assessment

Bioaccumulation of mercury and polychlorinated dibenzo-p-dioxins and dibenzofurans in salty water organisms

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