Comparison of induction and recovery between sevoflurane and halothane supplementation of anaesthesia in children undergoing outpatient dental extractions

Abstract

We have compared sevoflurane and halothane in a double-blind controlled study for supplementation of nitrous oxide and oxygen anaesthesia in 80 children undergoing dental extraction as outpatients. Induction of anaesthesia was more rapid in those who received sevoflurane compared with those who received halothane (89 s compared with 127 s for loss of eyelash reflex). In both groups, mean duration of administration of anaesthesia was less than 4 min. Those who received sevoflurane were slower to awaken (167 s compared with 102 s), although discharge times from hospital were similar. The incidence of complications during induction and maintenance was low in both groups and return to normal appetite and activity occurred in the majority of children on the same day. More children who received halothane suffered nausea after leaving hospital. We conclude that sevoflurane is a suitable alternative to halothane, with more rapid induction of anaesthesia, but in these short procedures, awakening time was slower than after halothane.

Vomiting after a pediatric adenotonsillectomy: comparison between propofol induced sevoflurane-nitrous oxide maintained anesthesia and TIVA with propofol-remifentanil

“…According to Ariffin et al [25] following anesthesia with sevoflurane or halothane in outpatients, the incidence of PONV prior to the discharge was relatively higher in the sevoflurane group, but it was significantly higher following discharge in the halothane group. These authors explained that sevoflurane has a faster clearance rate than halothane in an in vivo setting.…”

Sevoflurane in Paediatric Anaesthesia

“…[74] Discrepancies in results from various trials make it difficult to draw conclusions regarding time to discharge from the recovery area. This parameter did not differ to any significant extent between the 2 drugs in 2 studies, including the largest, [72] but differences were statistically significant in 2 other studies, notably the large well-designed trial by Lerman et al [74] In children undergoing dental surgery (table IV), time to induction was similar [46] or faster [79,80] with sevoflurane compared with halothane, but time to awaken was similar [80] or slower. [79] Time to discharge was generally similar.…”

Which anaesthetic agents are cost-effective in day surgery? Literature review, national survey of practice and randomised controlled trial

“…Johannesson and co-workers, 147 Lerman and co-workers 149 and Sury and coworkers 13 reported increased emergence agitation with sevoflurane over halothane. Viitanen and co-workers 162 and Ariffin and co-workers 138 found less vomiting and a more rapid emergence with sevoflurane.…”

“…Parameters such as the time to loss of eyelash response and the time to intubation were used as measures of induction times. Nine studies 13,138,143,147,149,151,153,164,166 showed that sevoflurane provided a more rapid induction than halothane. Another study provided evidence that sevoflurane provided a more rapid induction than halothane, but the difference was not statistically significant.…”

“…13,138,143,147,149,151,153,155,162,164,166 Only Piat and co-workers 155 did not record PONV before discharge, and only Meretoja and coworkers 151 reported a reduction in PONV before discharge with sevoflurane. Walker and coworkers, 164 Welborn and co-workers 166 and Naito and co-workers 153 recorded the rate of PONV after discharge, and did not find a difference between the two agents.…”