2010
DOI: 10.4097/kjae.2010.59.3.185
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Vomiting after a pediatric adenotonsillectomy: comparison between propofol induced sevoflurane-nitrous oxide maintained anesthesia and TIVA with propofol-remifentanil

Abstract: BackgroundAnesthesia methods and drugs affect postoperative nausea and vomiting. Propofol is known to have antiemetic effects. We compared the incidence of postoperative vomiting (POV) in children undergoing an adenotonsillectomy; anesthesia in one group was induced with propofol and maintained with sevoflurane and nitrous oxide, and the other group received total intravenous anesthesia (TIVA) with propofol-remifentanil.MethodsNinety children, ASA physical status I, were assigned randomly to one of two groups.… Show more

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Cited by 9 publications
(10 citation statements)
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“…The incidence of PONV in the PACU was the same in both groups with only one patient per group experiencing nausea. These results contradict studies that found the incidence of PONV to be significantly reduced in patients that received TIVA with propofol compared to patients that received inhalational anesthesia using sevoflurane [6,9,10] or inhalational anesthesia using other volatile anesthetics [11,12]. Although our study was limited by the number of patients enrolled (n=23), our findings are consistent with other larger studies that compared the incidence of PONV in patients anesthetized with TIVA using propofol and patients anesthetized with inhalational anesthesia using sevoflurane.…”
Section: Discussionsupporting
confidence: 69%
“…The incidence of PONV in the PACU was the same in both groups with only one patient per group experiencing nausea. These results contradict studies that found the incidence of PONV to be significantly reduced in patients that received TIVA with propofol compared to patients that received inhalational anesthesia using sevoflurane [6,9,10] or inhalational anesthesia using other volatile anesthetics [11,12]. Although our study was limited by the number of patients enrolled (n=23), our findings are consistent with other larger studies that compared the incidence of PONV in patients anesthetized with TIVA using propofol and patients anesthetized with inhalational anesthesia using sevoflurane.…”
Section: Discussionsupporting
confidence: 69%
“…These results contradict studies that found the incidence of PONV to be significantly reduced in patients that received TIVA with propofol compared to patients that received inhalational anesthesia using sevoflurane [6,9,10] or inhalational anesthesia using other volatile anesthetics [11,12]. Although our study was limited by the number of patients enrolled (n=23), our findings are consistent with other larger studies that compared the incidence of PONV in patients anesthetized with TIVA using propofol and patients anesthetized with inhalational anesthesia using sevoflurane.…”
Section: Discussioncontrasting
confidence: 57%
“…Although lidocaine was administered intravenously before the induction dose of propofol and locally to the sinuses, it was administered in both groups. Given the short half-life of lidocaine (approximately 10 minutes after initial parenteral administration and, after 30 minutes, a slower elimination phase of about 90 minutes) [9], the initial administration would have been metabolized by the end of surgery and it is unlikely that it had any effect post-operatively. Any molecular or chemical effects it may have had would have been present in both groups and therefore negligible.…”
Section: Discussionmentioning
confidence: 99%
“…Although the incidence of complications was significantly higher in the sevoflurane group, which showed conflicting results with rSO 2 values, all complications in the sevoflurane group were nausea. However, it is well known that PONV occur more frequently in sevoflurane anesthesia than in propofol anesthesia [ 27 ]. It is difficult to determine whether the nausea was a simple PONV or a complication of increased ICP.…”
Section: Discussionmentioning
confidence: 99%