Comparison of indomethacin and phenylbutazone in acute gout.

Smyth, Charley J.; Percy, J. S.

doi:10.1136/ard.32.4.351

Cited by 43 publications

(19 citation statements)

References 10 publications

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“…Colchicine has been in intermittent use since Byzantine times but it requires frequent administration, and gastrointestinal side effects too often terminate the treatment before the attack. Phenylbutazone is as effective as colchicine (Freyberg, 1962;Gutman, 1965) and untoward reactions occurring during the treatment of acute gout are rare (Smyth and Percy, 1973), although gastrointestinal intolerance and fluid retention are predominant among the side effects that occasionally limit its usefulness. Indomethacin in adequate dosage has been shown to be as effective as phenylbutazone (Smyth and Percy, 1973) but unpleasant side effects are not infrequent (Boardman and Hart, 1965).…”

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“…Phenylbutazone is as effective as colchicine (Freyberg, 1962;Gutman, 1965) and untoward reactions occurring during the treatment of acute gout are rare (Smyth and Percy, 1973), although gastrointestinal intolerance and fluid retention are predominant among the side effects that occasionally limit its usefulness. Indomethacin in adequate dosage has been shown to be as effective as phenylbutazone (Smyth and Percy, 1973) but unpleasant side effects are not infrequent (Boardman and Hart, 1965). There is therefore need for further exploration of safe and rapid therapy in acute gout, particularly as the sufferers are often relatively young and active members ofthe community.…”

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confidence: 99%

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Multicentre trial of naproxen and phenylbutazone in acute gout.

Sturge¹,

Scott²,

Hamilton³

et al. 1977

Annals of the Rheumatic Diseases

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SUMMARY Naproxen 750 mg as a single dose followed by 250 mg three times daily has been compared with phenylbutazone 200 mg four times daily for 48 hours followed by 200 mg three times daily for the treatment of acute gout in an open study on 41 patients.The drugs were equally effective with few and relatively mild side effects. Naproxen is a useful alternative agent for the treatment of acute gout.

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confidence: 99%

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confidence: 99%

Multicentre trial of naproxen and phenylbutazone in acute gout.

Sturge¹,

Scott²,

Hamilton³

et al. 1977

Annals of the Rheumatic Diseases

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“…Colchicine has been used for centuries but requires frequent administration and gastrointestinal side-effects often terminate treatment before resolution of the attack. Phenylbutazone is as effective as colchicine in the treatment of gout (Gutman, 1965), but is no longer licensed for this indication in the U.K. Indomethacin is as effective as phenylbutazone (Smyth & Percy, 1973), but unpleasant sideeffects are not uncommon when it is used in the treatment of gout (Boardman & Hart, 1965). Other non-steroidal anti-inflammatory drugs have been used to treat acute gout, but few have been formally evaluated.…”

Section: Introduction Methodsmentioning

confidence: 99%

Double‐blind trial of flurbiprofen and phenylbutazone in acute gouty arthritis.

Rc¹,

Goddard²,

Higgens³

et al. 1985

Brit J Clinical Pharma

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Flurbiprofen has been compared with phenylbutazone in a double-blind study involving 33 patients with acute gout. Patients received either flurbiprofen 400 mg daily for 48 h followed by 200 mg daily, or phenylbutazone 800 mg daily for 48 h followed by 400 mg daily. The drugs were of comparable efficacy, while side-effects were uncommon and relatively mild. Flurbiprofen appears to be a satisfactory alternative to phenylbutazone in the management of acute gouty arthritis.

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“…A number of head-to-head randomized controlled studies in acute gouty arthritis show equivalence between many NSAIDs (25)(26)(27)(28)(29)(30)(31)(32)(33). There are no randomized controlled trials directly comparing colchicine to NSAIDs.…”

Section: Pharmacological Treatmentmentioning

confidence: 98%