Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics

Porter, Alexandra E.; Patel, N. K.; Skepper, Jeremy N.; Best, Serena M.; Bonfield, W.

doi:10.1016/s0142-9612(03)00355-7

Cited by 383 publications

(285 citation statements)

References 33 publications

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“…If there are defaults in the crystal lattice or the crystal size is reduced, dissolution will be faster. Defects at the border between HA and the surrounding pre-existing bone may also be of importance [56]. Additives in the grafting material, e.g.…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

“…In vitro studies have already shown that substitution of Si for P ions into HA enhance osteoblast cell activity. Si substitution in sHAs also increases the dissolution of Ca and P during early stages of healing, which is an important precondition for bone formation ( [56,66]; see below). In vivo experiments in the rabbit revealed advanced bone formation [67].…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

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Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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“…[12] Initially, a HAp nanoparticle of composition similar to that found in previous experimental studies [6] was constructed using Ca…”

Section: Construction Of the Molecular Modelmentioning

confidence: 99%

Dissolving Hydroxyolite: A DNA Molecule into Its Hydroxyapatite Mold

Bertrán

Revilla-López

Casanovas

et al. 2016

Chemistry A European J

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Abstract:In spite of the clinical importance of hydroxyapatite (HAp), the mechanism that controls its dissolution in acidic environments remains unclear. Knowledge of such process is highly desirable to provide better understanding of different pathologies, as for example osteoporosis, and of the HAp potential as vehicle for gene delivery to replace damaged DNA. In this work, the mechanism of dissolution in acid conditions of HAp nanoparticles encapsulating double-stranded DNA has been investigated at the atomistic level using computer simulations. For this purpose, four consecutive (multi-step) molecular dynamics simulations, involving different temperatures and proton transfer processes, have been carried out. Results are consistent with a polynuclear decalcification mechanism in which proton transfer processes, from the surface to the internal regions of the particle, play a crucial role. Besides, the DNA remains protected by the mineral mold and transferred proton from both temperature and chemicals. These results, which indicate that biomineralization imparts very effective protection to DNA, also have important implications in other biomedical fields, as for example in the design of artificial bones or in the fight against osteoporosis by promoting the fixation of Ca 2+ ions.

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“…[54,55] HAp is not the only candidate for DNA protection: for example, silicates share some structural characteristics with apatite which would be compatible with DNA interactions. [56,57] Montmorillonite, illite, and kaolinite represent clay minerals that are able to protect DNA from nucleases during natural bacterial genetic transformation [58,59] and they are also useful for gene delivery as silica nanoparticles, but their slow degradation rate decreases efficiency [60,61] compared to HAp.…”

Section: Cell Deathmentioning

confidence: 99%

Surviving Mass Extinctions through Biomineralized DNA

Turón

Puiggalı́

Bertrán

et al. 2015

Chemistry A European J

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Even in the worst of conditions, such as those which occurred during mass extinction events, life on Earth never totally stopped. Aggressive chemical and physical attacks able to sterilize or poison living organisms occurred repeatedly. Surprisingly, DNA was not degraded, denatured or modified to the point of losing the capability of transferring the genetic information to the next generations. After the events of mass extinction life was able to survive and thrive. DNA was passed on despite being an extremely fragile biomolecule. The potential implications of hydroxyapatite protection of DNA are discussed including how DNA acts as a template for HAp formation, how cell death can trigger biomineralizatoin, and how DNA can be successfully released from HAp when the conditions are favourable for life.

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Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics

Cited by 383 publications

References 33 publications

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Dissolving Hydroxyolite: A DNA Molecule into Its Hydroxyapatite Mold

Surviving Mass Extinctions through Biomineralized DNA

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