Comparison of In Vivo Confocal Microscopy, Ultrasonic Pachymetry, and Scheimpflug Topography for Measuring Central Corneal Thickness

MeenakshiSundaram, Soundaram; Sufi, Aalia Rasool; Prajna, N Venkatesh; Keenan, Jeremy D.

doi:10.1001/jamaophthalmol.2016.2183

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Comparisons of these data to clinical normal values on other instrumentation are also being performed. For example, a previous work found that confocal microscopy overestimates corneal thickness compared to OCT . Our data, on average, is in line with density measures by another research team using the CS4 instrument .…”

Section: Discussionsupporting

confidence: 91%

“…2,[19][20][21] Comparisons of these data to clinical normal values on other instrumentation are also being performed. For example, a previous work found that confocal microscopy overestimates corneal thickness compared to OCT. 22 Our data, on average, is in line with density measures by another research team using the CS4 instrument. 3 This indicates that general concerns we have about data collection on this instrument such as the subject tiring are likely not impacting our results here in a meaningful way.…”

Section: Discussionsupporting

confidence: 84%

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The corneal nerve density in the sub‐basal plexus decreases with increasing myopia: a pilot study

Harrison

Putnam

Shukis

et al. 2017

Ophthalmic Physiologic Optic

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 84%

The corneal nerve density in the sub‐basal plexus decreases with increasing myopia: a pilot study

Harrison

Putnam

Shukis

et al. 2017

Ophthalmic Physiologic Optic

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“…There are different methods to measure corneal thickness, including ultrasound pachymetry, 6 confocal microscopy, 7 and slit scanning, Scheimpflug tomography. 8 9 The first two are contact methods that measure CCT at certain points and are associated with a possible risk of infection transmission.…”

Section: Introductionmentioning

confidence: 99%

Distribution pattern of total corneal thickness in keratoconus versus normal eyes using an optical coherence tomography

et al. 2022

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Purpose: To evaluate the total corneal thickness distribution pattern using a high-resolution spectral-domain optical coherence tomography (HR SD-OCT) for distinguishing normal eyes from keratoconus (KCN). Methods: One hundred and forty-four patients were enrolled in three groups (55 normal, 45 mild KCN, and 44 moderate-to-severe KCN eyes) in this prospective diagnostic test study. Total corneal thickness was measured in 8 semi-meridians using HR SD-OCT (Heidelberg Engineering, Heidelberg, Germany) in 5 and 7 mm zones. The central corneal thickness (CCT), corneal focal thinning (minimum thickness [Min], min minus median and maximum [Min-Med, Min-Max]), and asymmetry indices (inferior minus superior [I-S] and supranasal minus infratemporal [SN-IT]) were calculated. One-way analysis of variance and the area under the receiver operating characteristic curve (AUC) were used for the analysis. Results: Thinner CCT, lower Min thickness, more negative Min-Max, Min-Med, and greater I-S and SN-IT were found in KCN eyes compared to the control group ( P < 0.001). The inferior and IT semi-meridians were the thinnest locations in KCN cases in the 5 mm central zone ( P < 0.001). CCT followed by Min-Med had the highest discriminative ability for differentiating mild KCN (AUC, sensitivity and specificity: 0.822, 87.0%, 60.37% and 0.805, 82.93%, 66.0%, respectively) and moderate-to-severe KCN (0.902, 87.82%, 73.08% and 0.892, 85.37%, and 78.85%, respectively) from normal corneas. Conclusion: The inferior and IT sectors of the cornea with the largest thickness changes in the 5 mm zone are the most common thinning sites in keratoconic corneas, and CCT and Min-Med are the most sensitive indices for the diagnosis of KCN.

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The alterations of corneal biomechanics in adult patients with corneal dystrophy

Han²,

Wang³

et al. 2022

Eye

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Comparison of In Vivo Confocal Microscopy, Ultrasonic Pachymetry, and Scheimpflug Topography for Measuring Central Corneal Thickness

Cited by 4 publications

References 3 publications

The corneal nerve density in the sub‐basal plexus decreases with increasing myopia: a pilot study

The corneal nerve density in the sub‐basal plexus decreases with increasing myopia: a pilot study

Distribution pattern of total corneal thickness in keratoconus versus normal eyes using an optical coherence tomography

The alterations of corneal biomechanics in adult patients with corneal dystrophy

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