The alterations of corneal biomechanics in adult patients with corneal dystrophy

Wu, Mengliang; Han, Jing; Wang, Xiaochun; Shao, Tingting; Wang, Yan

doi:10.1038/s41433-022-01965-z

Cited by 1 publication

(2 citation statements)

References 35 publications

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“…The present study was designed on corneal biomechanical changes in a type of corneal dystrophy; however, the results show that GCD can cause an abnormal response in corneal biomechanical behavior compared to healthy corneas. This finding supports the higher CBI reported in cases with GCD compared to controls [ 39 , 40 ].…”

Section: Discussionsupporting

confidence: 90%

“…A recent study that compared DCR parameters measured using Corvis ST in GCD and normal eyes reported higher A1DA and lower SPA1 in the GCD group [ 40 ], while these parameters were not statistically significant in the present study. In addition to the age difference, this difference can be attributed to racial differences (Chinese versus Iranian).…”

Section: Discussioncontrasting

confidence: 85%

See 1 more Smart Citation

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Heidari

Momeni‐Moghaddam

Jadidi

et al. 2022

JCM

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Background: The aim of this study was to assess stress-strain index (SSI) and corneal biomechanical parameters in eyes with granular corneal dystrophy (GCD). Methods: This case-control study included 12 eyes of 12 patients with GCD (mean age 45.2 ± 18.7 years) and 20 eyes of 20 healthy individuals (mean age 54.4 ± 3.8 years). In addition to SSI, dynamic corneal response (DCR) parameters were assessed at the first and second applanation, including length (AL1, AL2), velocity (AV1, AV2), time (AT1, AT2), and deformation amplitude (DA A1, DA A2), and at the highest concavity (HC) phase, including DA, peak distance (PD), radius (HCR), and DA ratio (DAR 1 and 2 mm), by Corvis ST. Central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were considered covariates in comparing DCR parameters between the two groups. Results: SSI was statistically significantly lower in eyes with GCD than in normal eyes (p = 0.04). The corneal velocity towards the first applanation was 0.02 m/s faster in the GCD eyes AV1 (0.15 ± 0.02 vs. 0.13 ± 0.02 m/s, p < 0.001) and IR (7.48 ± 1.01 vs. 6.80 ± 1.22 mm, p = 0.003) parameters were significantly higher in the GDC group, while AT1 (7.33 ± 0.66 vs. 7.47 ± 0.36 ms, p = 0.002) and HCR (7.42 ± 0.76 vs. 8.20 ± 1.08 mm, p = 0.014) were significantly lower in the normal group. Conclusions: GCD led to a change in biomechanical properties of the cornea. SSI refers to fewer stiff corneas in GDC than normal.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 85%