Comparison of In Vivo Confocal Microscopic Findings between epi-LASIK Procedures with Different Management of the Epithelial Flaps

Chen, Wei-Li; Shen, Edward; Hsieh, Yi‐Ting; Yeh, Po-Ting; Wang, Tsung Jen; Hu, Fung-Rong

doi:10.1167/iovs.10-6390

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…Six RCTs and 3 comparative studies published between 2008 and 2011 met the inclusion criteria [7,8,9,13,14,15,16,17,18]. A total of 489 patients (958 eyes) underwent off-flap epi-LASIK and on-flap epi-LASIK.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 489 patients (958 eyes) underwent off-flap epi-LASIK and on-flap epi-LASIK. Patients’ mean age ranged from 20.25 to 33 years and the mean preoperative manifest spherical equivalent (MSE) ranged from –3.49 D to –9.14 D; 0.02% mitomycin C (MMC) was used for 15–120 s in 6 studies [9,13,14,16,17,18]. Each study revealed that there were no significant differences in preoperative demographic features and other factors that may have influenced surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported data for postoperative manifest refractive spherical equivalent [7,8,13,15,16,17,18]. Follow-up time ranged from 6 months to 1 year.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

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Objective: To examine possible differences in clinical outcomes between off-flap and on-flap epipolis laser in situ keratomileusis (epi-LASIK) for myopia. Methods: Pertinent studies were selected by extensive searches. A total of 9 studies reporting on a total of 958 eyes were included in the present meta-analysis. Statistical analysis was performed using RevMan 5.0 software. Results: There were no significant differences in the final refractive spherical equivalent (p = 0.38), manifest refractive spherical equivalent within ±0.50 D of the target (p = 0.76), final uncorrected visual acuity (p = 0.90), loss of ≧1 line of best spectacle-corrected visual acuity (p = 0.99), and corneal haze at 3 months postoperatively (p = 0.96) or more than 6 months (p = 0.64). More patients felt severe pain in the on-flap group than in the off-flap group, although this finding was not statistically significant (p = 0.05). However, off-flap epi-LASIK had a better mean uncorrected visual acuity at 3 days (p = 0.04) and 5 days (p = 0.01), and faster re-epithelialization (p < 0.00001) after surgery. Conclusions: According to the available data, off-flap and on-flap epi-LASIK had equal visual and refractive outcomes for the treatment of myopia. Off-flap epi-LASIK had more rapid re-epithelialization and visual recovery compared to on-flap epi-LASIK.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

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“…This finding suggested that the centripetal migration of remaining peripheral corneal epithelial cells occurred in order to quickly cover the denuded wound surface. [9][10][11] Cho et al 12 also found that in rabbit corneas after epithelial debridement, the morphology of initially healing superficial cells were elliptical and large. Changes from single to multiple layers of corneal epithelia implied that epithelial differentiation occurred.…”

Section: Discussionmentioning

confidence: 96%

“…To facilitate following analysis, the cells superficial to BECs were defined as corneal apical surface cells (ASCs) in this study, just as described in previous reports. 9,10 ICs were characterized by round hyperreflective nucleus under LSCM with an average diameter of o10 μm. DCs appeared to be hyperreflective corpuscular particles with dendritic processes, scattering among limbus or gathering in group.…”

Section: Image Analysismentioning

confidence: 99%

In vivo confocal microscopy of early corneal epithelial recovery in patients with chemical injury

Xiang

et al. 2015

Eye

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Purpose To investigate the early recovery of corneal epithelium in patients with chemical injuries by the application of in vivo laser scanning confocal microscopy (LSCM). Methods LSCM was performed on 26 eyes of 18 consecutive patients at 1, 2, and 3 months post injury. The morphology of central corneal epithelium and limbus was evaluated. Analysis was performed to compare the densities of corneal apical surface cells (ASCs) and basal epithelial cells (BECs) among different injury severity and time points after injury. The comparisons were also made on inflammatory cells (ICs) and dendritic cells (DCs) infiltrating at the limbus. Moreover, the presence rate of palisades of Vogt (POV) was analyzed at 3 months post injury. Results Corneal re-epithelialization was found within 3 months post injury in all eyes, except that persistent epithelium defect was identified in grade IV injured eyes even at 3 months after injury. The injury severity had a significantly negative correlation with the densities of ASCs. However, it had no relationship with the densities of BECs. The density of ICs at the limbus decreased significantly with the prolongation of follow-up, except in the grade I injured eyes. The presence rate of POV also had a significantly negative correlation with injury severity.Conclusion Epithelial recovery after chemical injury varied in cellular morphology and the densities of ASCs among eyes with different injury severity. The presence rates of POV decreased with the aggravation of injury. LSCM is a feasible method for observing the early recovery of corneal epithelium in patients with chemical injuries.

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Morphologic study of the cornea by in vivo confocal microscopy and optical coherence tomography after bifocal refractive corneal inlay implantation

Malandrini

Martone

Canovetti

et al. 2014

Journal of Cataract and Refractive Surgery

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Comparison of In Vivo Confocal Microscopic Findings between epi-LASIK Procedures with Different Management of the Epithelial Flaps

Cited by 14 publications

References 39 publications

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

In vivo confocal microscopy of early corneal epithelial recovery in patients with chemical injury

Morphologic study of the cornea by in vivo confocal microscopy and optical coherence tomography after bifocal refractive corneal inlay implantation

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